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Biomedical subjects

R R Gala

Publications and source records attributed to R R Gala.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Macroorchidism and testicular fibrosis associated with autoimmune thyroiditis.

A 16-year-old male with long-standing atrophic chronic lymphocytic thyroiditis was evaluated for macroorchidism. A testicular biopsy prior to treatment revealed peritubular and interstitial fibrosis, reduced spermatogenesis and sparse Leydig cells with nonprominent smooth endoplasmic reticulum. Biological/immunological LH and FSH ratios were reduced, I-LH and FSH response to GnRH was blunted, and levels of testosterone and androstenedione were low. Twenty-two months after thyroid treatment, the testicular size was unchanged, and the degree of fibrosis showed minimal regression. Spermatogenesis with normal morphology was present, Leydig cells with Reinke crystals were present, and surface area and diameter of the seminiferous tubules had increased only slightly. There was a normal I-LH and FSH response to GnRH, and normal levels of testosterone and androstenedione. This study, along with previous reports, suggests that the etiology of the hypothyroid state may influence the development of testicular fibrosis.

Adolescent↗
PubMedDate not supplied

Prolactin size heterogeneity in human follicular fluid: a preliminary study.

Follicular fluid from mature preovulatory follicles was examined for the presence of prolactin (PRL) heterogeneity. Two pools of follicular fluid aspirates were used: one from follicles in which the ova were successfully fertilized in vitro and the other from follicles in which the ova were not successfully fertilized. Follicular fluid aspirates were concentrated by ultrafiltration and subjected to Sephadex G-100 gel chromatography. Fractions were assayed for immunoactive PRL by radioimmunoassay (RIA-PRL) and for bioactive PRL by the Nb2 lymphoma cell bioassay (BA-PRL). The major portion of RIA-PRL activity appeared as a low-molecular-weight component and accounted for 88% of the total PRL activity in the fertilized group and 87% in the unfertilized group. A high-molecular-weight component was also evident (12% and 13% for the two groups, respectively). The high-molecular-weight component in both groups was not active as PRL in the bioassay. These results demonstrate that while two immunoactive, heterogeneous forms of PRL exist in human follicular fluid when measured by RIA, it is only the low-molecular-weight form of PRL that is biologically active as established by Nb2 lymphoma cell bioassay.

Biological Assay↗