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R R Kretschmer

Publications and source records attributed to R R Kretschmer.

63 records · Page 4Linked to original sources
PubMedDate not supplied

Bactericidal kinetics of newborn polymorphonuclear leukocytes against group B streptococci type III.

In vitro intracellular and total bacterial group B Streptococcus type III (GBS-III) survival as well as bactericidal indices at incubation times ranging from 0 to 120 minutes were comparable in newborn and adult polymorphonuclears (PMN). It appears that under appropriate opsonic conditions the phagocytic kinetics of normal newborn PMN against GBS-III are not different from those of adult PMN.

Adult↗
PubMedDate not supplied

In vitro and in vivo effect of heparin, chondroitin, dextran and protamine on the virulence of pseudorabies virus (Suid herpesvirus 1).

The possible antiherpetic effect of three polyanions (heparin, chondroitin sulfate and dextran sulfate), as well as one polycation (protamine sulfate) was tested in vitro and in vivo against pseudorabies virus (Suid herpesvirus 1). The in vitro experiments revealed that heparin, dextran sulfate and protamine sulfate significantly reduced the number of lytic plaques. Chondroitin sulfate only caused a decrease in mean plaque size. Experiments in vivo disclosed that heparin injected subcutaneously before the experimental infection, was the only polyanion that protected mice against pseudorabies virus. Protamine sulfate had a paradoxic effect: whereas in vitro it reduced the number of lytic plaques, in vivo it increased the lethality of pseudorabies virus. Chondroitin sulfate and dextran sulfate did not modify the virulence of the virus in mice.

Animals↗