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Biomedical subjects

R R Lanese

Publications and source records attributed to R R Lanese.

At least 19 recordsLinked to original sources
PubMed1990

Injury and disability in matched men's and women's intercollegiate sports.

Eight matched men's and women's intercollegiate varsity teams were studied prospectively for one academic year to determine the incidence of athletic injury and resulting disability. Sports in which both men and women participated in a comparable manner were chosen: basketball, fencing, gymnastics, swimming, tennis, indoor track, outdoor track, and volleyball. Men (232) and women (150) were injured at comparable rates, 42 percent versus 39 percent. When adjusted for exposure time, seven of the eight sports continued to show similar injury rates. Women gymnasts, however, experienced .82 injuries per 100 person-hours of exposure as compared to .21 injuries for the men (p = .0001). Disability was greater in women gymnasts, 7.44 days per 100 person-hours versus 1.15 days for men (p = .0004). Percent of season lost to injury was also greater for women gymnasts. Types and sites of injury were similar for men and women, with sprains and strains accounting for over half of all injuries. We found no evidence for gender differences in matched sports except for gymnastics, in which technically diverse events may have accounted for the differences observed.

Athletic Injuries↗
PubMed1985

Weight loss in amateur wrestlers and its effect on serum testosterone levels.

Levels of nine serum hormones, six skin-fold sites, and body weight were measured in 19 male amateur wrestlers during their competitive season and again two months after the season. Percent of body fat was estimated from skin-fold thicknesses. Body weight, body fat, testosterone level, and prolactin level were significantly lower during the wrestling season. Low serum testosterone levels were significantly correlated with low body fat, large loss of body fat, and large weight loss. These findings suggest that the dietary restriction practiced by some wrestlers may affect serum testosterone levels adversely.

Adipose Tissue↗
PubMed1985

Anabolic steroid use and perceived effects in ten weight-trained women athletes.

Ten women athletes who consistently used anabolic steroids were interviewed about their patterns of drug use and the perceived effects. Anabolic steroids were used in a cyclical manner, often with several drugs taken simultaneously. All participants believed that muscle size and strength were increased in association with anabolic steroid use. Most also noted a deepening of the voice, increased facial hair, increased aggressiveness, clitoral enlargement, and menstrual irregularities. The participants were willing to tolerate these side effects but thought that such changes might be unacceptable to many women.

Adult↗
PubMed1983

Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: II. High sucrose-fed animals.

The hypolipidemic properties of ethyl 6-chlorochroman-2-carboxylate (II), 6-phenylchroman-2-carboxylate (III) and 6-cyclohexylchroman-2-carboxylate (IV) were compared to clofibrate (I) in sucrose-fed fasted male Sprague-Dawley rats. All compounds were administered at doses of 0.2 and 0.4 mmol/kg, orally, twice daily for 7 consecutive days. In this model, II was a more effective hypocholesterolemic drug than clofibrate, whereas III and IV were inactive. Chlorochroman II, like clofibrate, decreased serum alpha-lipoprotein cholesterol and pre-beta-lipoprotein triglyceride concentrations and concomitantly increased serum beta-lipoprotein triglyceride concentrations. In clofibrate-treated rats, serum free cholesterol concentrations increased concurrent with a reduction in serum lecithin: cholesterol acyltransferase activity, but no such correlation was observed for II. Only II lowered liver cholesterol levels and increased liver triglyceride levels. No consistent inhibition of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase activity was observed with these analogs. The observed changes in triglyceride and cholesterol concentrations among serum lipoproteins were of a greater magnitude after chlorochroman II and clofibrate administration to sucrose-fed rats than in our previous studies using chow-fed fasted rats. These data suggest that chloro-substitution at the 6-position of the phenylchroman ring is important for hypolipidemic activity of these cyclic clofibrate analogs.

Animals↗
PubMed1982

Injuries among wrestlers in school and college tournaments.

We studied four wrestling tournaments that totaled 1,049 participants of grade school, high school, and college age levels. Two clearly serious injuries occurred: a wrist fracture and an elbow dislocation. Knee and ankle sprains of mild to moderate severity were the most common diagnoses. No injuries to the pinna occurred probably because ear protectors were worn. Nine- to 14-year-old boys were injured least frequently (3.8%), partly because their matches were the shortest. The overall injury rate for high school and college wrestlers was 12.0%. Risk of injury did not vary with weight class or with successive matches. Thirty-nine percent of all injuries were because of aggravation of old injuries. Thus, rehabilitation after injury is believed to be an important preventive measure. These findings suggest that, although most injuries in wrestling are not severe, attendance at tournaments by medically trained personnel is warranted.

Adolescent↗
PubMed1981

Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: I. Chow-fed animals.

The hypolipidemic properties of ethyl 6-chlorochroman-2-carboxylate (II), ethyl 6-phenylchroman-2-carboxylate (III) and ethyl 6-cyclohexylchroman-2-carboxylate (IV) were compared to clofibrate (I) in fasted normolipidemic rats. The chroman analog II, like its parent compound, clofibrate, reduced serum and alpha-lipoprotein cholesterol concentrations. Although analog III had no effect on serum cholesterol, it caused a slight elevation of alpha-lipoprotein cholesterol concentration. Serum free cholesterol was increased and LCAT activity was reduced in clofibrate-treated rats. The hypolipidemic agents had no consistent effect on liver lipid concentrations and liver microsomal HMG-CoA reductase activity. In addition, we have shown that drug efficacies varied directly with seasonal variations in serum lipid concentrations.

Animals↗
PubMed1980

Diurnal variation of prolactin secretion differentiates pituitary tumors from the primary empty sella syndrome.

In an attempt to find an endocrine function test that might be useful in differentiating the primary empty sella syndrome from a pituitary tumor, we evaluated 24-hour prolactin levels in seven patients with the primary empty sella syndrome, 16 patients with pituitary tumors and 37 normal subjects. All eight patients with the primary empty sella syndrome had normal 24-hour mean prolactin levels and normal diurnal variation of prolactin release whereas in each patient with a pituitary tumor nocturnal prolactin secretion was blunted. In light of these findings and those of other investigators, we do not perform routine invasive study of the pituitary in patients with (1) a typical clinical presentation of the empty sella syndrome, (2) no endocrinopathies, (3) a normal computerized axial tomography scan, when indicated, and (4) normal serum prolactin levels with intact diurnal variation.

Adolescent↗
PubMed1978

Differences in pulmonary function tests among whites, blacks, and American Indians in a textile company.

Normal standards for pulmonary function in nonwhite populations are not presently available to occupational health workers. The present study examined differences in %FVC, FVC, FEV1/FVC, FEF 200-1200 and FEF 25-75% among whites, blacks, and American Indians. The sample consisted of 4209 job applicants to a textile company in southeastern United States. Multiple regression and analyses of covariance were employed to control differences in age, height, weight, and smoking status. Blacks were significantly lower in five of the six comparisons but higher in FEV1/FVC%. The pulmonary function measures of Indians fell generally between those of whites and blacks. Differences were observed between blacks and whites of both sexes regarding the effects of cigarette smoking. The need for race specific stardards was confirmed and the question of using smokers in the acquisition of normative data was raised.

Adult↗
PubMed1978

Serum chromium and angiographically determined coronary artery disease.

Human aortas sampled from populations where there is little advanced atheromatous plaque formation contain higher concentrations of chromium than do aortas from populations in which atheromatosis is prevalent. In the present study serum cholesterol, triacylglycerols, and chromium (Cr3+) concentrations were measured in 32 subjects in whom coronary artery disease was assessed by cineangiography. The distribution of subjects with diseased and normal arteries overlapped below 5.50 microgram of chromium per liter. Only subjects free of coronary artery disease had chromium concentrations greater than or equal to 5.50 microgram/liter. The role of chromium was assessed in the context of the selected risk factors: cholesterol, triacylglycerols, and systolic and diastolic blood pressure. The group with coronary artery disease had significantly lower serum chromium concentrations than did the group with normally patent arteries.

Adult↗
PubMed1977

Disordered nocturnal prolactin regulation in women with breast cancer.

Mean 24-hr prolactin concentrations were determined in 25 female control subjects, 16 women with benign breast masses, and 23 subjects with breast cancer. This evaluation performed before breast surgery revealed significantly decreased (p less than 0.02) nocturnal (12 a.m. to 7 a.m.) prolactin concentrations in 12 postmenopausal breast cancer subjects that contrasted with significantly increased (p less than 0.05) nocturnal prolactin levels in five luteal-phase premenopausal women with breast cancers. Prolactin concentrations in patients with benign breast disease were not significantly different from control subjects. Two of the premenopausal breast cancer patients had marked preoperative elevations in their mean 24-hr prolactin levels, and they were two of the three subjects who have since expired. Nocturnal prolactin secretion was significantly decreased (p less than 0.03) in four premenopausal breast cancer patients when they were studied 1 year after surgery; however, it remained the same in the eight postmenopausal breast cancer patients similarly evaluated. Although disordered prolactin regulation has been found in these women with breast cancer, its role in the etiology and progression of human cancer is still uncertain.

Adult↗
PubMed1977

Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.

Mean 24-hr growth hormone, luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone concentrations determined preoperatively in 16 women with benign breast masses and 17 patients with breast cancer were similar to those levels found in 25 age- and weight-matched control subjects. Mean 24-hr testosterone levels, however, were significantly elevated in women with breast cancer evaluated in the luteal phase of their cycles and were normal in postmenopausal breast cancer women. In addition, serum thyroid-stimulating hormone, thyroxine, cholesterol, and triglyceride levels were normal in these subjects. Plasma cortisols and urinary 17-hydroxysteroid excretion tended to be higher in both the benign and malignant breast disease group and probably reflected preoperative anxiety. Hence, we have found normal concentrations of a variety of endocrine and other biochemical agents that can stimulate breast tissue growth and/or have been previously reported to be disordered in women with breast cancer.

Adult↗