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R R Lideman

Publications and source records attributed to R R Lideman.

13 recordsLinked to original sources
PubMed1992

[Nerve growth factor and the state of serotoninergic system in endogenous depression and mental retardation].

Platelet parameters of the serotonin system were studied in patients with endogenous depressions and children with late documented phenylketonuria (PKU) before and after antidepressive therapy. There was a significant decrease in the rate of back platelet uptake of 3H-serotonin and an increase in the sensitivity of serotonin receptors to serotonin in the patients before therapy and normalization of these parameters after therapy. The normalization correlated with clinical improvement in patients with endogenous depression. The course therapy with L-DOPA and the antidepressant azaphen resulted in a substantial mental improvement in children with PKU. There was a significant reduction in the ability of platelets from the patients in question to react by releasing 3H-serotonin in response to nerve growth factor stimulation of cells in vitro.

Adolescent↗
PubMed1979

[Conformational changes in the heat-denatured nucleotide complex of human lymphocytes on subsequent cooling].

The microfluorometric technique allowed an assay of the chromatin state from binding of acridine orange in studies on the kinetics of conformational changes in the nucleoprotein complex (NP) of human peripheral blood lymphocytes. Extraction of F1 histone fraction with 0.01 N HCl (pH 2) substantially altered (decelerated) conformational changes in the NP complex. Extraction of F1, F2 and F3 histone fractions with 0.25N HCl (pH 0.6) led to a more pronounced deceleration of the kinetics of conformational changes. The latter ones were decelerated as well when the process was run in a more viscous medium (e. g. in a 70% glycerin solution). No conformational changes in the NP complex deproteinized with 0.25N HCl were revealed in a vicsous medium. In such a case the NP complex showed low F530 values and elevated values of the alpha coefficient that seems likely to suggest the nonreversible denaturation of the NP complex.

Cell Nucleus↗
PubMed1978

[Opiate receptors and endogenous morphines: a new approach to the study of the brain].

The paper deals with a range of problems connected with a study of a nature and a function of specific neuronal receptors and endogenous morphines. It is demonstrated that a further development of studies in the given area will be of a principal significance in solving the cardinal problems of psychopharmacology and a search for biological bases of mental diseases. The most perspective ways of studying functional opiate receptors and endogenous morphines in schizophrenia are discussed.

Adenylyl Cyclases↗
PubMed1978

[Possible role of genetic factors in increasing the serum neurotropic activity of schizophrenic patients].

The authors studied the accumulation of individuals with an increased neurotropic blood serum activity among the relatives of schizophrenic patients. In order to evaluate the degree and character of the genetical determination of the biological indices 2 independent approaches were used: the method of a sequential search of genetical significant threshold values of signs (within the framework of a poligenic Falkoner-Edwards model) and the method of a partition of the total phenotypic variance into main compounds on the basis of intrafamilial correlations. It was demonstrated that the studied signs are characterized by a very high degree of a genetical determination. It is assumed that the small amount of specific loci (major genes) with the effect of intraloci dominance or intraloci epistatic interaction are responsible for the given biological marker.

Genes↗
PubMed1978

[Decrease in the thrombocyte monoamine oxidase activity of schizophrenic patients].

The authors measured the monoaminoxidase activity in thrombocytes of 28 schizophrenic patients and in 36 normal donors. The monoamine oxidase activity in schizophrenic patients was decreased by 14% and in the subgroup of patients with continuous schizophrenia by 19.5% as compared to that of normals. The monoamine oxidase activity in schizophrenic female patients did not significantly differ from the norm, while the male patients differed highly significantly from the normal. The decrease of monoamine oxidase activity correlated with the level of negative disorders (r = 0,71; P less than 0,01). A correlation with positive disorders was not noted.

Adult↗
PubMed1978

[Role of serum factors in decreasing the reaction of peripheral blood lymphocytes in schizophrenia to PHA stimulation].

The blood serum of schizophrenic patients and three of its studied fractions (gamma-globulins and remaining after elimination of gamma-globulins and ultrafiltrate protein fractions) inhibit the lymphocyte response of normals to PHA stimulation (an increase of the DNA content in cells). An insignificant inhibitor effect in the blood serum of normals was seen only in the protein fraction. The PHA precipitating activity of the blood serum in schizophrenic patients which is mainly connected with its protein fraction is increased by 30%. However, there are no correlations between this blood serum activity and its capability to inhibit the response of lymphocytes to PHA stimulation.

Cells, Cultured↗
PubMed1976

[Serum humoral factors--cause of the altered physiologic state of peripheral blood lymphocytes in schizophrenic patients].

Statistically significant correlations were revealed between the following: the percentage content in the lymphocyte cultures of patients suffering from schizophrenia of cells responding to stimulation with phytohemagglutinin (PHA) by DNA synthesis, and the percentage in the white blood cell cultures of healthy donors of lymphocytes failing to respond to the PHA stimulation by the DNA synthesis as a result of cultivation of these cells in a medium containing the blood serum (20%) of schizophrenic patients. Similar correlation was revealed between the percentage content in cultures of the white blood cells of schizophrenic patients of adhesive lymphocytes and the percentage of adhesive lymphocytes in the white blood cell cultures of healthy donors in cultivation of these cells in a medium containing the blood serum (20%) of schizophrenic patients. The data obtained confirmed a supposition that the altered physiological condition of the peripheral blood lymphocytes of patients suffering from schizophrenia was caused by the factors contained in the blood serum of these patients.

Adult↗
PubMed1975

[A microfluorometric study of cell nucleus DNP-complex renaturation].

A study of the kinetics of renaturation of the DNP in the nuclei of human peripheral blood lymphocytes with the aid of modified Riglers method showed the absence of renaturation of the preparations preliminarily headed to 65 degrees C. Heating the preparations to higher temperatures (75, 85 and 100 degreesC) led to the appearance of characteristic renaturation profiles with the maximum at a two-minute incubation (direct measurement of the intensity of fluorescence of the nuclei of cells transfered into a cold citrate-salt solution, as a time function).

Acridines↗
PubMed1975

[Effect of acid extraction of basic proteins on the binding of acridine orange by cell chromatin].

The binding of acridine orange to chromatin of fixed human lymphocytes is increased after stepwise removal of histones by hydrochloric acid. No changes in the dye-binding features of the cells were found after f1 histone extraction (0.01 N HC1). Additional extraction of f2 and f3 by 0.05 N HC1 (partial extraction) and by 0.25 N HC1 (more complete extraction) resulted in increased binding of acridine orange (1.9 and 2.5 of that of the control, respectively).9222

Acridines↗