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Biomedical subjects

R R Millis

Publications and source records attributed to R R Millis.

At least 127 records · Page 7Linked to original sources
PubMed1980

Value of needle biopsy in outpatient diagnosis of breast cancer.

Outpatient needle biopsy of suspected breast cancers has been performed on 151 patients. Of 135 who were ultimately diagnosed as having a malignant tumor, 107 were correctly diagnosed on the initial needle biopsy, a success rate of 79%. The procedure is well tolerated by most patients and enables family support during a very stressful period. Furthermore, outpatient histopathologic confirmation of cancer allows adequate preoperative investigation and more efficient use of operating theater time.

Biopsy, Needle↗
PubMed1980

Assessment of axillary lymph node status.

Three methods of assessing axillary lymph node status were compared: In 149 patients assessed clinically, positive nodes were not detected in 31 (45%) of 69 patients with pathologic Stage II disease. Histologic examination of selected axillary nodes biopsied from 54 patients immediately prior to mastectomy, failed to detect metastatic disease in 11 (42%) of 26 patients with pathologic Stage II disease. Examination of lymph nodes in the axillary tail of 95 mastectomy specimens failed to diagnose axillary involvement in six (14%) of 43 patients with pathologic Stage II disease. Thus, none of the techniques determined the extent of axillary node involvement.

Axilla↗
PubMed1980

Breast tissue inclusions in axillary lymph nodes.

This report describes a female of 54 years with a past history of repeated breast biopsies all showing benign epithelial hyperplasia. The patient subsequently had a simple mastectomy and axillary lymph node biopsy. No evidence of malignancy was found in the specimen but there were numerous foci of epithelial hyperplasia in the breast and one axillary lymph node was extensively replaced by similar tissue. The danger of mistaking benign inclusions in lymph nodes for metastatic malignancy, particularly in tissue examined by cryostat section, is emphasized. The possible aetiology of such lesions is briefly discussed.

Axilla↗
PubMed1979

Elastosis and response to endocrine therapy in human breast cancer.

Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross elastosis, indicating that this simple method might provide a useful predictive index for response to endocrine therapy. In addition, tumours with oestrogen-receptor activity (a feature associated with a high rate of response) but with no elastosis were unlikely to respond, suggesting that a combination of the 2 predictive indices might be more valuable than either taken alone.

Breast Neoplasms↗
PubMed1978

Contraceptive steroids and breast cancer.

The prognosis and pathological findings in 44 patients with breast cancer who had taken contraceptive steroids during the year before diagnosis were compared with those in 44 controls matched for age and parity. No significant differences between the two groups were found in the histological features of the tumour or extent of axillary lymph-node disease. In patients with axillary node disease the recurrence rate in the controls was significantly higher than in the study group and more of the control patients had died. It is concluded that oral contraceptives have no untoward effect on the prognosis of breast cancer.

Adult↗
PubMed1978

Oestrogen receptors and the response to endocrine therapy in advanced breast cancer.

The relationship between oestrogen-receptor protein (ER) content of the tumour and the response to endocrine therapy was determined in 119 patients, in a collaborative prospective study. Twenty-eight of the 80 patients with measurable ER responded to treatment according to UICC criteria, compared with only 3/39 without ER. It was found that site of biopsy did not influence the result, but tumour content of the tissue sample was significantly related to the presence of receptors. The organizational problems of such a study are discussed.

Breast Neoplasms↗
PubMed1976

Biopsy of the impalpable breast lesion detected by mammography.

Specimen radiology plays an essential part in the surgical management of the impalpable breast lesion detected by mammography. It also plays a necessary part in the complete pathological examination of the specimen. A method for preoperative localization of the mammographically detected impalpable breast lesion is described.

Biopsy↗
PubMed1976

The xeroradiographic appearances of some uncommon malignant mammary neoplasms.

The clinical and xeroradiographic appearances are described of four patients with malignant lymphomatous involvement of the breast, two with breast involvement by acute leukaemia, and four with primary fibrosarcoma of the breast. In one patient with malignant lymhoma and multiple palpable masses, the radiological appearance resembled benign mammary dysplasia, but in the three other patients, one with a discrete clinical mass, and two with diffuse clinical involvement, radiological examination of the breast showed skin thickening with diffuse abnormalities of the trabecular pattern, most marked in the subdermal area. One of the patients with leukaemia had a discrete palpable mass and the other had diffuse clinical involvement, but the radiological appearances in both patients were similar and resembled those of a carcinoma. The clinical and radiological appearance of the patients with fibrosarcoma were those of a benign cyst or a fibroadenoma.

Adolescent↗
PubMed1976

The detection and significance of calcifications in the breast: a radiological and pathological study.

The radiological detection of calcification is compared using xeroradiography, non-screen film and a film-screen combination. The "threshold" values of the smallest detectable size of calcification, under simulated clinical conditions, are found to be approximately 100 mum for xeroradiography and 400 mum for both the film techniques in this study. The incidence of calcification seen on the preoperative mammograms of patients with carcinoma of the breast is 48-5 per cent. Further calcification revealed by histological examination raises the overall incidence of calcification in mammary carcinomas to 63 per cent. The incidence on preoperative mammograms in benign breast disease is 20 per cent. The radiological features of calcification occurring in malignant and benign breast lesions are recorded, and no definitive distinguishing features are established. The histological appearance of calcification in malignant and benign breast disease is discussed.

Breast Diseases↗
PubMed1975

In situ intraduct carcinoma of the breast: a long term follow-up study.

Twenty-eight patients with in situ intraduct carcinoma of the breast are reviewed. Two patients had bilateral tumours. The numbers of patients treated by wide local excision, simple mastectomy and mastectomy with axillary dissection were approximately equal; none of these patients died of carcinoma. The conclusions regarding prognosis and treatment of in situ intraduct carcinoma of the breast are discussed.

Adult↗
PubMed1972

Congenital dilatation of the intrahepatic bile ducts with cholangiocarcinoma.

Intrahepatic cholangiocarcinomas were found at necropsy in two previously reported cases of congenital dilatation of the intrahepatic bile ducts. The nature of the developmental abnormality is discussed and compared with other forms of biliary dilatation. Slow-flowing bile for many years probably leads to cholangiocarcinoma.

Adenoma, Bile Duct↗