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Biomedical subjects

R R Rao

Publications and source records attributed to R R Rao.

At least 37 records · Page 2Linked to original sources
PubMed1985

Pre-clinical toxicity studies on the new nitroimidazole 1-methylsulphonyl-3-(1-methyl-5-nitroimidazole-2-yl)-2- imidazolidinone.

Administration of 1-methylsulphonyl-3-(1-methyl-5-nitro-2-imidazole-yl)-2-imidazolidinone (Go 10213) at a dose of 5000 mg/kg to rat, mouse, guinea pig and rabbit and 3000 mg/kg to dog did not induce any toxic symptoms or mortality. Repeated daily gavaging with doses ranging from 50-3000 mg/kg/day were tolerated by rats for 2 weeks. No mortality was noticed in treated animals. Reduction in weight gain was observed in male rats on 2000 mg/kg per day and females on 1000 mg/kg per day. No toxic changes were noticed in dogs treated with 200 mg/kg per day for 2 weeks. One monkey treated with 75 mg/kg per day for 4 weeks tolerated the compound without exhibiting any toxic effects. No drug induced alterations were noticed in rats gavaged with 60 and 200 mg/kg per day for 4 weeks. Rats treated with a daily dose of 600 mg/kg showed reduction in body weight gain and atrophy of testes and these changes were reversible after stopping of medication. Dogs medicated with 30 and 100 mg/kg per day tolerated the drug for 4 weeks. Except slight ataxia in a few dogs treated with 100 mg/kg per day, no other drug induced toxic effects were noticed. Neurological symptoms were noticed in all dogs on high dose of 200 mg/kg. Three animals out of six were sacrificed in extremis in this dose. After discontinuation of Go 10213 all dogs on 100 and 200 mg/kg per day recovered normal gait in about a week. No definitive drug induced changes were noticed in laboratory investigations, gross and histopathological examinations.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1983

Evaluation of the teratogenic potential in Ciba-Geigy Go 10213, a new nitroimidazole derivative: 1-methane-sulphonyl-3-(1-methyl-5-nitro-1H-imidazole-2-yl)-2- imidazolidinone, an amoebicide, trichomonicide and giardicide, in giardicide, in rats.

With a view to evaluate the possible teratogenic potential of 1-methane-sulphonyl-3-(1-methyl-5-nitro-1H-imidazole-2-yl)-2-imidazolidi none (Go 10213), groups of pregnant rats were medicated orally with: 0, 100, 300 and 600 mg/kg of the compound daily from day 6 to day 15 of gestation. Foetuses were removed on day 20 of gestation, and were examined for their mortality, size, weight and any gross malformation. One third of the foetuses were fixed in Bouin's Fluid and sectioned by Wilson's technique for histological evaluation. The remaining pups were examined for the skeletal anomalies. CIBA-GEIGY Go 10213 appears to be neither embryotoxic nor teratogenic to the rat-foetuses, when the mothers were medicated at the aforesaid doses, during their critical phase of the pregnancy.

Abnormalities, Drug-Induced↗
PubMed1980

Toxicological effects of aerial application of monocrotophos.

Aerial application of the insecticide Nuvacron 40% (monocrotophos) had no significant effect on the cholinesterase level of plasma and erythrocytes of cattle, chicken, buffaloes, and human volunteers exposed to the spray. Contamination of canal water with the pesticide was completely eliminated within 24 hr, whereas that in the soil was reduced by 80% in 72 hr. The degradation of insecticide residue in grass was about 90% in seven days and in cotton leaves about 85% for the same period.

Adult↗
PubMed1977

In vitro studies on the effects on granular gland secretion in Xenopus laevis skin of stimulation and blockade of alpha and beta adrenoceptors of myoepithelial cells.

Secretion from the granular glands of Xenopus laevis skin was stimulated by alpha-adrenergic agonists, an effect which was blocked by alpha-adrenergic antagonists and inhibited by beta-adrenergic agonists, db-cAMP and diazoxide. The inhibition by isoprenaline and salbutamol, but not that by diazoxide, was blocked by a beta-adrenergic antagonist. It is concluded that the myoepithelial cells surrounding the secretory compartment of the granular glands bear alpha and beta adrenoceptors, and that the beta receptors comprise, or at least include beta2 receptors.

Adrenergic alpha-Agonists↗