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Biomedical subjects

R R Reddy

Publications and source records attributed to R R Reddy.

11 recordsLinked to original sources
PubMed2001

Porous silicon based potentiometric triglyceride biosensor.

A novel method for estimating triglycerides is reported. Porous silicon, prepared from p-type (100) crystalline silicon was thermally oxidized and used to immobilise lipase, an enzyme, which hydrolyses triglycerides resulting in the formation of fatty acids. This causes a change in the pH of the solution. Enzyme solution-oxidized porous silicon-crystalline silicon structure was used to detect changes in pH during the hydrolysis of tributyrin as a shift in the capacitance-voltage (C-V) characteristics. Detailed calibration of the sensor is included.

Biosensing Techniques↗
PubMed1996

Epidemiology of symptomatic human rotaviruses in Bangalore and Mysore, India, from 1988 to 1994 as determined by electropherotype, subgroup and serotype analysis.

Epidemiology of symptomatic rotaviruses from Bangalore and Mysore in Southern India was investigated. While serotype G3 predominated throughout the 7-year study period from 1988 to 1994 in Bangalore, serotype G1 was more predominant than serotype G3 in Mysore during 1993 and 1994. Serotype G2 strains were either not detected or infrequently observed in both the cities. However, several strains with subgroup I and 'short' RNA pattern that exhibited high reactivity with typing MAbs specific for serotype 2 as well as other serotypes were detected throughout the period. Among the nonserotypeable strains from both cities, several exhibited dual subgroup (SGI + II) or subgroup I specificity and 'long' RNA pattern indicating their probable animal origin. Notably, a gradual, yet highly significant reduction in rotavirus gastroenteritis, from 45.3% in 1988 to 1.8% during 1994, was observed in Bangalore in stark contrast to the consistently high (about 34%) incidence of asymptomatic infections among neonates by I321-like G10P11 type strains during the same period. Moreover, I321-like asymptomatic strains were not detected in children with diarrhea.

Antibodies, Monoclonal↗
PubMed1994

Decreased adhesiveness and altered cellular distribution of fibronectin in fibroblasts from schizophrenic patients.

Relative to those from normal subjects, cultured skin fibroblasts from schizophrenic patients have been found to show abnormal growth characteristics and morphology. This study compared skin fibroblasts from 10 drug-free schizophrenic patients and 10 normal control subjects on cell adhesiveness to the substratum. Relative to fibroblasts from normal controls, those from patients showed significantly decreased cell adhesiveness, with no overlap in distribution between the groups. Since fibronectin, a major cell surface molecule, is known to be involved in the fibroblast adhesion to substratum, its extracellular and intracellular distribution was determined by immunocytochemical analysis. Both extracellular and intracellular levels of fibronectin were significantly lower, and the distribution was altered in fibroblasts from the patients.

Adult↗
PubMed1992

Exclusive asymptomatic neonatal infections by human rotavirus strains having subgroup I specificity and "long" RNA electropherotype.

A large number of stool specimens, of healthy newborn infants, collected from various hospitals and clinics in Bangalore City, India, have been examined for the presence of asymptomatic rotaviral excretion. Out of 370 samples analysed during a three year period from 1988 to 1991, 133 specimens (36%) were positive for rotavirus RNA. All these asymptomatic neonatal strains, without exception, showed "long" RNA pattern, but subgroup I specificity. Serotype analysis by ELISA or by hybridization with serotype-specific probes indicated that these strains probably represent a new serotype in newborn children. We find an exclusive association of human rotaviruses having "long" RNA pattern and subgroup I specificity with asymptomatic neonatal infections in contrast to the earlier observations of association of such unusual strains with acute gastroenteritis in young children.

Antigens, Viral↗
PubMed1991

Multifocal Langerhans cell histiocytosis of the jaws: a case report.

Langerhans cell histiocytosis is an uncommon disease that includes a spectrum of disorders in which there is an abnormal proliferation of Langerhans cells. This article describes a case of a benign form of multifocal Langerhans cell histiocytosis of the maxilla and mandible. The patient was followed for a period of 2 1/2 years, during which time there was spontaneous remission of some of the lesions.

Adult↗
PubMed1987

The high rate of prevalence of CT-detected basal ganglia calcification in neuropsychiatric (CNS) brucellosis.

Of 65 cases presenting with neuropsychiatric manifestations of brucellosis (CNS-brucellosis), 9(13.8%) had CT-detected basal ganglia calcification (BGC). Of these, 5 had meningitis and 4 had psychiatric manifestations as presenting features. The diagnosis of brucellosis was made by the finding of consistent history and physical findings and the presence of significantly elevated antibody titres and/or positive culture in the blood and/or CSF. In all the cases, BGC was in the form of punctate hyperdense non-enhancing shadows with average density 44.5-58.4 and maximum density 49-64HU. The calcification was unilateral in 3 cases, bilateral and symmetrical in 4 and bilateral but asymmetrical in 2. None of the cases had other predisposing conditions to BGC and in one of the cases did specific anti-brucella treatment effect a detectable change in the BGC. The finding of CT-detected BGC in patients coming from areas endemic for brucellosis should alert physicians to the possibility of underlying brucellar infection.

Adolescent↗
PubMed1983

The endoscopic variety of duodenal villous adenoma - an experience with ten cases.

Ten cases of villous adenoma of the duodenum among 8,754 endoscopic examinations of the upper gastrointestinal tract were found over a nine year period. The varied clinical manifestations included gastrointestinal bleeding in five cases, partial duodenal obstruction in four, and jaundice with common bile duct obstruction in two. In only two cases did radiological examination indicate the diagnosis of villous adenoma of the duodenum in all ten cases preoperatively but was negative for carcinoma in one. Due to improved diagnostic techniques villous adenoma of the duodenum is being diagnosed at an early stage, and with appropriate surgical treatment the survival rate for this group of patients should improve.

Adenocarcinoma↗
PubMed1981

Duodenal polyps: diagnosis and management.

Forty-five polyps were encountered at duodenoscopy between 1973 and 1978. Upper gastrointestinal x-rays were helpful in 25 patients, 13 of whom had duodenal polyps and 12 duodenal deformity or mass lesions. Polyps in 23 patients were larger than 1 cm in size. Biopsies were done in 38 patients; in 19 there was only normal duodenal mucosa or chronic inflammation. Eight adenomatous polyps, six villous adenomas, two Brunner's gland hyperplasia, two lipomas, and one carcinoid tumor were found. Surgery was performed in eight patients and endoscopic polypectomy in four. We conclude that 1) small duodenal polyps are frequently missed on upper gastrointestinal x-rays, but these are submucosal polyps of little significance; 2) in general, polyps cannot be differentiated endoscopically into tissue categories, but villous adenomas show some characteristic features which allow a dependable endoscopic diagnosis; 3) a villous adenoma warrants excision because of the high incidence of malignancy; and 4) pedunculated duodenal polyps can be removed safely with endoscopic snare excision.

Adult↗