[Gastric acid production in infants of the first year of life with regurgitation syndrome and vomiting and concomitant perinatal CNS pathology].
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Biomedical subjects
Publications and source records attributed to R R Shiliaev.
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Cerebral hemodynamics has been studied rheoencephalographically in 39 infants early in the course of complicated pneumonia and in 19 healthy controls. The former exhibited phasic changes in cerebral circulation. On the disease day 3 and 10, a significant reduction in the blood flow took place. In children under 6 months of age cerebral circulation is less active than in those over 6 months throughout the whole acute period of complicated pneumonia.
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A study was made of the rheological blood properties, microcirculation, central and cerebral hemodynamics in children of the first year of life with complicated pneumonia. On admission to the department of intensive care and resuscitation the patients demonstrated pronounced hemorheological and hemodynamic disorders which might in many respects determine the disease gravity. Based on an analysis of the clinical observations and hemodynamic findings 3 periods of complicated pneumonia were distinguished in such children: the critical period, stabilization and repair. Each period is characterized by different compensatory adaptive and non-adaptive erythrocytic and hemodynamic reactions.
Red cell suspension filtration through synthetic filters is the most prevalent method for estimation of red cell deformability. A modified technique with the use of cellulose acetate filters manufactured by the Polimersintez Research and Production Amalgamation in the town of Vladimir is suggested. Employment of these filters will help introduce this test in clinical practice.
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Explore the source record for details and available documents.
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It was demonstrated that human and horse hemoglobin variants having quantitative difference in the interaction with dipalmitoyllecithin exhibit features of generality. The latter is manifested in the established hydrophobic contacts between protein and lipid in hydrated films discovered by IR spectroscopy. The arrangement of hydrophobicity profiles of hemoproteins demonstrated in amino acid sequences of chains the existence of intermittent hydrophobic and hydrophilic regions. Such a composition of hemoglobins could underlie their property to participate in hydrophobic interactions with lipids.
Blood rheology was assessed in 23 infants with acute pneumonia complicated with respiratory infectious toxicosis during hospitalization to intensive care wards, a control group consisted of 19 healthy infants. Plasma viscosity, red cell deformability, surface architectonics, and aggregation were studied. Patients developed increased plasma viscosity, marked reduction of red cell deformability, and increased aggregation index parallelled by reduced rate of aggregate formation. Changed red cell surface architectonics was associated with a reduced count of discocytes and parallel increase of echinocytes and cupola-like red cell forms. These data evidence marked disorders of blood rheology which should be not disregarded when choosing therapeutic policy.
Study of red cell surface structure is a highly informative method for the assessment of the body status in health and disease. The authors have examined the surface red cell structure of infants in health and disease by phase-contrast and scanning electron microscopy and came to the conclusion on the high reliability of the data obtained by phase-contrast microscopy. They recommend this unsophisticated and informative method for clinical practice.