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Biomedical subjects

R Ramírez Camacho

Publications and source records attributed to R Ramírez Camacho.

13 recordsLinked to original sources
PubMed2002

[Cochlear cytotoxic activity of cisplatin in experimentation animals. A study using scanning electron microscopy].

Cisplatin is an antitumoral agent commonly used in the treatment of different solid tumors. Its use induces adverse effects like oto- and nephrotoxicity due to acute renal failure. This makes it a suitable drug when creating an experimental model of ototoxicity. Our aim is to study the cellular lesions induced in the cochlea of the rat and the guinea pig by variable doses of cisplatin injected intraperitoneally, after short, middle, and long term survival, by means of scanning electronic microscopy. Results show the global effect of the cells of the organ of Corti with a more intense initial damage of the supporting cells, continuing with the late effect of the sensorial cells.

Animals↗
PubMed2001

[Atrophy of the tympanic membrane in contact with hydroxyapatite prosthesis: physiopathologic approach].

The implantation of ossicular replacement prothesis made of dense hydroxyapatite (HA) appears to be a wider method of reconstruction of ossicular chain damaged by suppurative processes or surgery. A review of 19 patients who underwent implantation of HA prosthesis disclosed 4 cases of extrusion and 3 cases of atrophy. When X-ray diffraction analysis of explanted commercially available prosthesis made of dense HA was compared with the results with porous implants and with HS powder employed in the manufacture of both, is suggested that tympanic membrane atrophy could be caused by mechanical and/or chemical factors.

Atrophy↗
PubMed2000

Sensorineural hearing loss and Mondini dysplasia caused by a deletion at locus DFN3.

OBJECTIVE: To study a family with inner ear malformations and sensorineural hearing loss. DESIGN: Clinical, radiological, and genetic study of the members of a family with different degrees of sensorineural hearing loss. RESULTS: The males in the family manifested profound congenital hearing loss with severe inner ear malformations, while the only affected female had progressive hearing loss that had begun during puberty. Computed tomography showed inner ear malformations in both males, with enlarged internal auditory meatus and Mondini dysplasia. Genetic analysis disclosed a microdeletion at the locus DFN3 on chromosome X. CONCLUSION: A familial Mondini dysplasia is associated to a microdeletion at the deafness locus DFN3.

Adolescent↗
PubMed2000

[Perilymphatic gushers: myths and reality].

The term perilymphatic gusher refers to the escape of inner ear fluid under pressure through the oval window, generally during surgery for otosclerosis. It also appears during cochlear implantation. We reviewed the morphological aspects of the temporal bone of patients with perilymphatic gusher. The cases of three patients with the features of cerebrospinal fluid leaks under pressure cited in the literature are described. Anatomic and pathologic features are discussed in the light of knowledge of molecular genetics.

Adult↗
PubMed2000

[Tubal involvement in nasopharyngeal carcinoma].

Nasopharyngeal carcinomas are frequently diagnosed in advanced stages in patients who present with secretory otitis or neck mass. However, survival after treatment is directly related to early diagnosis. The present study analyzed Eustachian tube involvement in nasopharyngeal carcinoma as a pathogenic mechanism in secretory otitis. The presence of otologic symptoms was correlated with the morphological description of the tumor and clinical manifestations in 198 patients with nasopharyngeal carcicoma.

Carcinoma↗
PubMed2000

[Mixed tumor (pleomorphic adenoma) of head and neck. Typical and atypical patterns].

Pleomorphic adenoma is a benign growth frequently encountered in major salivary glands, although minor salivary glands sometimes can be affected. In the latter non-specific clinical signs allows only the postoperative diagnosis. Nevertheless the existence of lesser salivary glands outside the oral cavity, and therefore pleomorphic adenomas, justify the specialist's need of its knowledge because of the difficulties arising in differential diagnosis. The AA. present a review of 22 cases in various sites treated in their Department in a 9 year-term.

Adenoma, Pleomorphic↗
PubMed1999

[Inflammatory pseudotumor of the larynx].

Inflammatory pseudotumors are rare and usually located in lung, although they can develop in any organ. They are unusual in head and neck and very rare in the larynx. A case of laryngeal pseudotumor in a patient with odinophagia and neck pain is reported. After diagnosis, the patient was treated with steroids, which produced complete resolution. These lesions can simulate malignant neoplasms and must be considered in the differential diagnosis.

Aged↗
PubMed1997

[Treatment protocol for sudden deafness].

There are two types of rapidly progressive sensorineural hearing loss: sudden hearing loss, which is generally unilateral and develops in less than 72 hours, and rapidly progressive sensorineural hearing loss, which develops over days or months. The origin of sudden deafness is difficult to establish. Several etiopathogenic factors have been postulated, such as viral infection, autoimmune origin, vascular and metabolic disease, rupture of the labyrinthine membrane, and, recently, immune-mediated inner ear disease. We made a retrospective study of 40 patients seen in our department. Patients were given a combined treatment with steroids, nimodipine, heparin, and oxygen. Patients were divided into two groups by intravenous or oral treatment.

Adolescent↗
PubMed1997

[Immune-mediated inner ear disease: report of clinical cases].

Many clinical and experimental studies have obtained evidence of immune-mediated inner ear disease. Discrepancies between theories of the mechanisms of injury to the inner ear and the laboratory tests that identify it mean that the diagnosis is based on clinical symptoms and a positive response to treatment. We report four cases of immune-mediated inner ear disease characterized by endolymphatic hydrops, fluctuating hearing loss, sudden deafness (first symptom of primary Sjögren's syndrome), and rapidly progressive sensorineural hearing loss.

Adult↗
PubMedDate not supplied

[Tympanosclerosis. I: proposed anatomical-surgical classification].

Tyrnpanosclerosis continues to be a clinically and pathogenically controversial topic. The options for dealing with it range from a conservative approach using hearing aids to surgery. With a view to justifying our therapeutic criteria, 29 cases of tympanosclerosis, out of a total of 200 surgical operations for otorrhea, were reviewed. An anatormical-surgical classification was established for use in approaching specific therapy for each particular case.

Cerebrospinal Fluid Otorrhea↗
PubMedDate not supplied

[Preservation of hearing in labyrinthectomies for cholesteatoma].

Destruction of the membranous labyrinth can lead to sensorineural hearing loss. This is especially frequent in surgery for active otorrhea. However, destruction of the posterior labyrinth sometimes can be solved without loss of cochlear function. We report three cases of partial labyrinthectomy for intralabyrinthine cholesteatoma without functional loss. Current theories regarding the conservation of hearing are discussed.

Adult↗
PubMedDate not supplied

[Sudden hearing loss and uveitis as a form of presentation of neurosarcoidosis].

Sarcoidosis is a multisystem granulomatous disease of unknown cause with frequent pulmonary, ocular, and lymphatic system manifestations. Central nervous system involvement, although rare (1 to 5%), most commonly affects the cranial nerves. Cranial nerve VIII abnormalities occur in 20% of these patients and are associated with other neuropathies and organ or system involvement. We report a case of neurosarcoidosis that presented as isolated sudden sensorineural hearing loss and uveitis.

Adolescent↗