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Biomedical subjects

R Reding

Publications and source records attributed to R Reding.

At least 91 records · Page 5Linked to original sources
PubMed1990

Surgery in patients on long-term steroid therapy: a tentative model for risk assessment.

Increased morbidity after operation has been associated with long-term steroid therapy. To determine the correlation between steroid therapy and such morbidity, the perioperative course of 55 steroid-treated patients was reviewed: 27 had bronchopulmonary disorders (group P) and 28 had non-pulmonary diseases (group NP). There were six (11 per cent) deaths, of which three were steroid related. Among the 13 non-lethal postoperative complications, eight were considered to be steroid related in group P and one in group NP. The duration of steroid therapy was for a median of 24 months (range 1-408 months) in group P and for a median of 6 months (range 1-240 months) in group NP (P less than 0.01). In contrast, the daily dose of hydrocortisone or equivalent before operation was significantly lower in group P, with a median of 0.51 mg kg-1 day-1 (range 0.20-2.56 mg kg-1 day-1) than in group NP, with a median of 1.20 mg kg-1 day-1 (range 0.23-7.38 mg kg-1 day-1) (P less than 0.01). In conclusion, bronchopulmonary disorders requiring a long duration of steroid therapy are associated with a higher risk of steroid-related complications after surgery. A convenient mathematical model is proposed which may allow a preoperative assessment of surgical risk, using steroid dose and duration of treatment.

Adult↗
PubMed1990

Electrostimulation of healing abdominal incisional hernias by low frequency, bipolar, symmetrical rectangular pulses. An experimental study.

A total of 107 male Wistar rats had abdominal hernias repaired (3 weeks after they had been artificially induced) by a two layer closure of the abdominal wall--the Mayo technique. The wounds of 56 rats were subjected to constant stimulation by an electric flow field. An implanted stimulation unit provided a low frequency (0.87 Hz), bipolar, symmetrical rectangular pulsed current (+/- 25 microA). A control group were given units that did not transmit current. In 39 of the 51 animals in the control group the muscle margins of the abdominal scars separated by between 1 and 5 mm. The scars of the electrostimulated animals were distinguished histologically by early formation of fibroblasts and deposition of collagen and the rapid maturation and longitudinal alignment of the collagen fibres. 46 of 56 of these scars were not separated. This technique may have a clinical application as adjuvant treatment for relapses of incisional hernias.

Abdominal Muscles↗
PubMed1990

[Reconstructive pancreas surgery in chronic pancreatitis].

An account is given in this paper of possibilities for reconstructive procedures, primarily in the wake of partial pancreatectomy, with reference being made to experience obtained by the author form surgical treatment of chronic pancreatitis. Benefits and setbacks of various methods are discussed in some detail, for example, duodenum or stomach preservation. The author continues to support cephalic duodenopancreatectomy with pancreaticogastrostomy on patients with chronic pancreatitis, however, with due observance of stringent criteria. That approach is considered equal to drainage methods.

Anastomosis, Roux-en-Y↗
PubMed1989

[The morphogenesis of the structural changes of the exocrine pancreas after ligation of the excretory duct].

UNLABELLED: The changes in the exocrine pancreas were investigated after ligature of the excretory duct in 51 Wistar rats. A qualitative microdetermination of the epithelial cells was carried out in the originated ductulus-like structures. CONCLUSIONS: The acinic epithelial cells grow atrophically first of all and become necrotic in the end. A dedifferentiated acinic cellular atrophy with metamorphosis to a ductulus-like cell type could not be observed. Proliferative and preproliferative events occur in the duct epithelial cells. Cystic ductulus-like structures originated from this. These fill out the former acinic areas by immature, few differentiated, pluripotent epithelial cells that look similar to embryonal pancreatic cells.

Animals↗
PubMed1987

[Catheter problems in the use of ventricular cardiovascular assist systems].

The prerequisite for efficient assist-ventricles and impulses in the pulsatile pumping function are sufficiently dimensioned afflux and flowing off connections. In systematic investigations on the hydraulic circulation model the cannulas from an internal parameter of 12 mm with a total length of the connection distance to the inflow and outflow valve, respectively, at the bypass ventricle of 30 cm proved sufficient for performing a volume of output of 5-6 l/min in clinic-relevant filling pressures in a hypodynamic circulatory situation. Connection cannulas for the heart-lung machine used in routine work are not sufficient in periodic filling and ejection processes in the pulsatile pumping function for an effective decompression and effective increase of the cardiac output. In case of an ECG-triggered mode of action of the ventricular assist-system an increase of frequency up to 130/min in after that incomplete filling of the assist-ventricle does not remarkably restrict the effectiveness of the assist-system.

Assisted Circulation↗
PubMed1987

[Chronic pancreatitis. Current aspects of the value of various reconstruction procedures].

After partial resection of the pancreas, particularly in the cephalic part, reconstructive procedures regarding drainage for bile-, gastric- and pancreatic juice are necessary. How far a non-derivage of the pancreatic rest is allowed, remains unclear. We prefer after cephalic resection of the pancreas the pancreato-gastrostomy on 46 patients. The assessment of pancreatic-intestinal anastomoses is controlled by histological examination. We have evaluated several long-term results and come to the conclusion, that there is no big difference between various techniques of operation in chronic pancreatitis. The consequences of chronic pancreatitis cannot be cured.

Ampulla of Vater↗