[Colour contact enzymatic test in prevention of uterine cervix cancer (author's transl)].
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Biomedical subjects
Publications and source records attributed to R Reisenauer.
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Plasma renin activity (PRA) stimulated by upright posture was measured in 300 men aged 45-64 years using a radioimmunoassay of angiotensin-I. The examined subjects were normotensive or patients with benign essential hypertension and were divided into 6 groups according to the absence of manifest atherosclerosis, the presence of definite angina pectoris or a history of myocardial infarction. Each group contained 50 unselected subjects, with a comparable mean age. Significant differences in mean PRA were found between corresponding groups of hypertensives and normotensives, the values in hypertensives being lower. The percentage of low renin values was higher in hypertensives with ischaemic heart disease than in other groups. It is suggested that this finding might be explained by functional disturbances in the kidneys in hypertensives with ischaemic heart disease.
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Analysis of body height was performed in the control group of 500 well-fertile men and in 829 patients with various forms of testicular pathology such as hypoplasia of testicles, unilateral and bilateral cryptorchism, hypogonadotrophic eunuchodism, and Klinefelter's syndrome. A statistically greater average height was found in bilateral cryptorchids, unilateral cryptorchids with an adequate spermiogenesis, hypogonadotrophic eunuchoids and chromatin-positive men. The greatest difference, when compared with the control group, was found in patients with a Klinefelter's syndrome. The authors hold the view that the plasmatic testosterone values are not the only factor conditioning the termination of the process of growth into height in males. Importance must also be given to the lowered sensibility of epiphysial growth zones to male sex hormone; this reduced sensibility is especially to be seen in chromatin-positive men.
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A longitudinal epidemiological study of ischaemic heart disease (IHD) in men aged 40-59 years showed that the five-year incidence of the manifest form was 7.8% in agricultural workers and 9.7% in industrial employees. The corresponding incidence of the latent form was 9.0% and 12.2%, respectively. The differences in the incidence of both forms between the population samples studied was at the border of statistical significance. The importance of risk factors was evaluated on the basis of the score represented by the difference between the respective five-year incidence of IHD in subjects with and without the risk factors concerned. The highest relative scores were found with systolic and diastolic hypertension, positive family history and obesity. For prognostic purposes, the total relative risk, represented by the sum of the scores of the risk factors proved to be useful. Autopsies confirmed that a total relative risk exceeding 40% was a sensitive indicator of morphological substrate of coronary heart disease.
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