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Biomedical subjects

R Requena

Publications and source records attributed to R Requena.

13 recordsLinked to original sources
PubMed2001

Oronasal fistula repair with three layers.

We present an innovative method for closure of oronasal fistulas involving a three-layer repair, consisting of septal mucosa flap, bone or cartilage graft, and palatal mucosa flap. The septal mucosa flap closes the nasal side of the defect. This is an inferiorly based flap along the nasal floor and consists of septal mucosa from the side opposite the oronasal fistula. A slit is created in the remaining layers of the nasal septum, allowing the flap to be delivered into the defect. When the septal flap is folded down in this fashion, it exposes nasal septal bone and cartilage. The bone and cartilage are harvested and are used to create the middle layer of the three-layer fistula repair. The oral layer of the repair is provided by a palatal mucosa transposition flap. This method allows the bone/cartilage graft to be sandwiched between two vascular layers. We have successfully used the three-layer repair on three patients. All of the oronasal defects were 2 cm in size. All patients are at least 1 year after repair with 100 percent closure; thus, no oronasal leakage. The flaps both septal and palatal resulted in no morbidity once healed. Specifically, the surgically created slit in the nasal septum is well mucosalized and barely discernible. Also, no nasal obstruction occurs from the septal flap on the floor of the nose. We perform the procedure on an outpatient basis. The three-layer repair can be used in adult patients with oronasal fistulas of the middle and posterior hard palate up to 3 cm in size. This technique is not recommended for children.

Aged↗
PubMed1990

Meiotic and sperm chromosome studies in a reciprocal translocation t(1;2)(q32;q36).

Meiotic and sperm chromosomes were studied in a man heterozygous for a reciprocal translocation t(1;2)(q32;q36). Forty-five meiotic metaphase I cells were obtained from semen samples: 86.6% were 22,XY,IV and 13.3% had synaptic anomalies that affected all or some of the bivalents. The quadrivalents observed had a ring configuration (92.3%) or a chain configuration (7.7%). A total of 105 sperm chromosome complements were analyzed: 41% resulted from an alternate segregation, and the percentage of unbalanced sperm was 59%; most of them (71%) resulted from an adjacent 1 segregation. The frequency of anomalies unrelated to the translocation (5.7% numerical and 14.1% structural anomalies) were within the normal range for control donors. There was a good correspondence between the percentage of cells with a ring IV (92.3%) and the proportion of 2:2 segregations (88.6%) and between the percentage of chain IV (7.7%) and the incidence of 3:1 segregations (11.4%).

Chromosomes, Human, Pair 1↗
PubMed1987

Autologous fibrin glue as a sealant of the common bile duct.

Autologous fibrin glue was evaluated as a sealant of the common bile duct (CBD) with the use of experimental animal models. It proved to be highly effective. Since it is a safe product that can be easily obtained from the patient's own blood, it may find useful application in most biliary tract procedures, liver transplants, and hepatectomies.

Animals↗
PubMed1986

Upper extremity lymphedema secondary to mammary cancer treatment.

Upper extremity lymphedema resulting from the radiation or surgical therapy of breast cancer is quite common and can approximate 25% in some series. To treat patients with this condition, a special lymphedema clinic was started in 1979. To date, 150 patients have been enrolled. They have had their lymphedema for periods of 1 month to 14 years. Treatment was either by sequential pumping using a special device (Lymphapress) or by microsurgery. The surgery consisted of multiple lymphovenous anastomoses without sutures, carried out on the medial aspect of the affected upper arm. Thus far, 102 anastomoses have been performed in 15 patients. The results of both treatment methods have been very encouraging.

Adult↗
PubMedDate not supplied

Septal replacement for severe anterior septal deviation.

PURPOSE: To introduce a novel surgical technique for treatment of severe anterior septal deviation. MATERIALS AND METHODS: Retrospective case series set in a tertiary-care hospital. Ten patients were treated over an 18-month period. External septorhinoplasty and septal replacement for severe anterior septal deviation. Postoperative clinical nasal examination and photographic comparison. RESULTS: Ten patients were treated with septal replacement for severe anterior septal deviation over an 18-month period. All patients were followed for a minimum of 1 year. No postoperative complications were seen. All patients reported a subjective improvement in their nasal airway and nasal appearance. This was confirmed with clinical examination and photographic comparison. CONCLUSION: Septal replacement for severe anterior septal deviation is a viable option for select patients who can not be successfully treated with conventional techniques.

Adult↗