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Biomedical subjects

R Rimón

Publications and source records attributed to R Rimón.

At least 73 records · Page 4Linked to original sources
PubMed1981

Serum and CSF levels of haloperidol by radioimmunoassay and radioreceptor assay during high-dose therapy of resistant schizophrenic patients.

Serum and cerebrospinal fluid (CSF) levels of haloperidol were measured in 12 chronic neuroleptic-nonresponsive schizophrenic patients after 1 month on 60 mg haloperidol daily and then again after 1 month on 120 mg haloperidol daily. Serum haloperidol and CSF haloperidol rose with increasing dose. Serum and CSF levels were significantly correlated. No clinical improvement was achieved despite the high serum and CSF drug levels.

Drug Resistance↗
PubMed1981

Haloperidol, thioridazine and placebo in mentally subnormal patients-serum levels and clinical effects.

A randomized cross-over trial was conducted in 30 restless mentally subnormal patients by increasing the dosage of haloperidol from 10 to 60 mg and that of thioridazine from 100 to 600 mg daily. The clinical effects of drug holidays on placebo and serum drug levels were also examined. There were more relative drug-responders than nonresponders or negative responders. Correlation between clinical response and drug serum levels was poor, probably owing to the heterogeneity of disorders treated. Mesoridazine and other metabolites had 5-6 times higher serum levels than the parent compound, and relatively high serum levels are achieved already with moderate doses. The observed differences between haloperidol and thioridazine treatment were surprisingly few. Serum cholesterol was higher (P less than 0.05) at the end of thioridazine than of the haloperidol administration.

Adolescent↗
PubMed1981

Prolactin levels in cerebrospinal fluid of patients with chronic schizophrenia.

Baseline concentrations of prolactin (PRL) was determined in the CSF of 28 lobotomized and 28 non-lobotomized patients with chronic schizophrenia. The mean PRL level of the female patients was significantly higher than that of the male patients (p < 0.001). In addition, non-lobotomized patients had significantly higher concentrations of CSF PRL than patients of the lobotomized group (p < 0.05). On the other hand, patients belonging to the latter group exhibited significantly more central as well as cortical brain atrophy than the patients on whom no psychosurgery had been performed (0.05 > p < 0.001). The significance of cerebrospinal PRL as an index of central dopamine metabolism is discussed.

Adult↗
PubMed1980

Cerebrospinal fluid endorphins in schizophrenia.

Opioid-receptor-active material, endorphins, has been measured in cerebrospinal fluid samples obtained from schizophrenics. A chromatographic procedure isolated the Fraction I endorphin which was quantitated in a receptorassay. At least two cerebrospinal fluid samples were obtained from each patient, at Day 0 with no medication and at Days 30 and 60 after medication with fluphenazine under standardized conditions. Three series of patients were included: acute schizophrenics (= 11); re-entry schizophrenics (n = 7) who have previously been treated with neuroleptics but were readmitted to hospital usually as a consequence of stopped medication, and chronic schizophrenics (n = 9) who had been without neuroleptics for at least 2 weeks prior to Day 0. At Day 0, 6/9 acute cases, 4/6 of re-entry and 2/9 chronic cases had endorphin levels above the range of healthy volunteers. The levels in chronic cases were significantly lower than those in acute cases. Treatment with neuroleptics significantly lowered the endorphin levels in acute cases. These results confirm and extend previous observations.

Adult↗
PubMed1980

Münchausen syndrome: a review and two case reports.

In the light of the pertinent literature, 2 illustrative cases of the Münchausen syndrome are presented. In both patients there had been dynamically significant losses in the oedipal age leading to an intense feeling of being rejected. Both patients also exhibited problems of dependence, perfectionistic attitudes toward the self, and fear of social failure. In addition, characteristics typical of alexithymia could be noted. As a dynamical interpretation it is proposed that in these patients basic helplessness and inadequacy of expressing feelings have been channelled into multiform psychosomatic symptoms. The latter in turn have caused continuous seeking for acceptable somatic etiology and treatment of the symptoms. Thus, gradually, the clinical picture of the Münchausen syndrome has developed.

Adolescent↗
PubMed1979

[Follow-up survey of vasectomy in Finland].

A follow-up study of 107 healthy males was conducted on average 4.7 years after vasectomy. Altogether 24 % of the subjects mentioned great satisfaction with the outcome of the surgical procedure; 74 % of the patients reported "general satisfaction", and only 2 % appeared dissatisfied with regard to the performed vasectomy. In no instance had postoperative psychiatric complications been observed. In 32 % of the patients the sexual potency was said to have improved after vasectomy, whereas 3 % reported impairment of sexual function following the operation.

Adult↗
PubMed1979

Attitudes towards criminal and other patients.

Staff attitudes towards mentally abnormal offenders were investigated on a forensic psychiatric assessment ward as reflected in a drug trial. The attitude towards drug trials was negative in 79% of the personnel, in contrast to 71% positive in three Swedish mental hospitals. Of the respondents 75% considered that drug treatment did not benefit the patients. Then the attitudes of 21 general physicians towards assessment and drug treatment of mentally abnormal offenders as well as towards 10 illnesses were measured by self-rating scales employing a 10-cm line technique. Both the assessment and drug treatment of mentally abnormal offenders were the least favoured as compared with somatic illnesses. Other neuropsychiatric disorders ranked with them were also very significantly (P less than 0.001) less favoured than pneumonia. They considered that these attitudes were shared in general by medical and nursing staff

Antisocial Personality Disorder↗
PubMed1979

Relationship between life stress factors and viral antibody levels in patients with juvenile rheumatoid arthritis.

Serum specimens from 46 patients with JRA were tested for measles CF, HI, HLI, and RNP-GP antibodies, for rubella HI antibodies, and for adenovirus and herpes simplex virus CF antibodies. The mean antibody titres of the 16 JRA patients of the major conflict group (14) were generally higher than those of the 30 patients of the non-conflict group, although the differences do not reach the level of statistical significance. The interrelationships between life stress, emotions and immunological changes in JRA are discussed.

Adenoviruses, Human↗
PubMed1979

Immunoglobulin G antibodies to herpes simplex type 1 virus detected by radioimmunoassay in serum and cerebrospinal fluid of patients with schizophrenia.

Serum and CSF specimens from 16 schizophrenic patients and 18 nonpsychiatric controls were tested by radioimmunoassay for immunoglobulin G antibody of capsid, envelope and excreted antigens of herpes simplex type 1 virus. There were no significant differences in the antibody levels between the schizophrenic patients and the controls. The etiological role of viruses and virus-like agents in schizophrenia and some methodological aspects are discussed.

Adult↗
PubMed1979

Monoamine metabolite levels in cerebrospinal fluid and brain atrophy in lobotomized schizophrenic patients.

Baseline concentrations of homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA) and MHPG in the cerebrospinal fluid (CSF) were determined in 67 lobotomized and 30 non-lobotomized patients with chronic schizophrenia. In addition, in 69 of these patients the degree of brain atrophy was assessed by a pneumoencephalographic (PEG) technique. There were no significant differences in the concentrations of the monoamine metabolites in the CSF between the two patient groups studied despite the fact that the group of lobotomized schizophrenics had significantly more central and cortical brain atrophy than the group of nonlobotomized schizophrenic patients. The amine metabolite levels were also unrelated to the subtype of schizophrenia, duration of illness, or degree of mental incapacitation.

Atrophy↗
PubMed1978

Serum and CSF antibody levels to herpes simplex type 1, measles and rubella viruses in patients with schizophrenia.

Serum and CSF specimens from 12 schizophrenic patients and 10 non-psychiatric controls were tested for herpes simplex type 1 virus neutralizing antibody and for measles and rubella haemagglutination inhibiting antibodies. There were no significant differences in the distribution of virus antibody titres in serum or CSF specimens between the patients and the controls. The possible aetiological role of viruses or virus-like agents in schizophrenia and some methodological aspects are discussed.

Antibodies, Viral↗
PubMed1975

Aggression in general-hospital patients.

The Buss-Durkee Inventory (BDI) rating for measuring aggression was performed on 125 consecutive female patients admitted to a general hospital. The test scores of different diagnostic groups were all on a intermediate level, and with the exception of slightly lower scores in patients with blood disorders, only few differences statistical significance were observed. The factor analysis of the test results revealed three factors: in addition to aggression factor (I) and hostility factor (II) a factor called remorse factor (III) was identified. The patient groups divided according to their medical diagnoses showed no differences with regard to these factors. The variance of factor scores could not be explained by such background variables as social class, marital status or domicile. There was, however, a highly significant negative correlation (-0.33) between age and the aggression factor. Finally, the concept of suppressed aggression and hostility and the role of aggression dynamics in the development of organic illness is discussed.

Adult↗