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R Rimon

Publications and source records attributed to R Rimon.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Plasma interleukin-1 beta and sleep architecture in schizophrenia and other nonaffective psychoses.

OBJECTIVE: It has been reported that sleep deprivation may enhance interleukin (IL)-1 beta production of healthy subjects. Furthermore, patients with acute psychoses have been reported to exhibit higher levels of IL-1 beta than healthy controls. The present study examined polysomnographic sleep and morning IL-1 beta plasma values in 20 drug-free patients with acute nonaffective psychoses. METHODS: Ten patients with DSM-III diagnosis of schizophrenia, five with delusional disorder, and five with atypical psychosis underwent polysomnographic sleep registrations and their morning blood levels of IL-1 beta were measured. RESULTS: IL-1 beta values correlated negatively with the length of the sleep period (p = 0.010) and the relative time of rapid eye movement (REM) sleep (p = 0.038), and positively with REM latency (p = 0.043). CONCLUSIONS: It is concluded that reduced sleep, possibly especially reduced REM sleep, may be a reason for increased morning IL-1 beta values in these patients. Additional studies on IL-1 beta in psychiatric patients should consider the possibility of sleep disturbances as a possible explanation for deviations in IL-1 beta levels.

Adolescent↗
PubMedDate not supplied

Cyclic AMP and GMP in the cerebrospinal fluid after high-dose haloperidol treatment.

Very high dose haloperidol treatment failed to reduce cyclic AMP in cerebrospinal fluid of schizophrenic patients, whereas phenothiazines have been reported to do so. This may represent in vivo evidence for the distinction between neuroleptics that block D1 receptors (adenylate cyclase linked) and neuroleptics that do not.

Cyclic AMP↗