Hyperhomocysteinaemia in Parkinson's disease.
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Biomedical subjects
R Roebroek
Publications and source records attributed to R Roebroek.
Elevated plasma levels of homocysteine in Parkinson's disease.
Significantly elevated plasma levels of homocysteine, but not cysteine and cysteinylglycine, were found in treated parkinsonian patients compared to controls. Elevated levels of homocysteine may be either caused by an unknown endogenous metabolic disturbance or by antiparkinsonian treatment, because no association to severity or duration of disease was found. Based on the results of this study one may speculate that homocysteine may be an independent risk factor for vascular disease in Parkinson's disease.
Aged↗
Occult cerebrovascular malformations: 2 cases.
Since the introduction of high accuracy CT scanning and MR imaging, angiographically occult cerebrovascular malformations are a relatively common finding. The clinical presentation is usually related to hemorrhage. Asymptomatic intralesional bleeding frequently occurs. Currently, MR imaging is the most sensitive method for the detection of occult cerebrovascular malformations. The dynamic nature of these malformations seems to be a key factor in their therapeutic management. We present 2 cases of occult cerebrovascular malformations and discuss the clinical presentation, neuroradiologic appearance and current management of these lesions.
Adult↗