Biomedical subjects

R Rogozea

Publications and source records attributed to R Rogozea.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Interictal responsiveness in therapy-resistant partial epilepsy.

A polygraphic study of the somatic, autonomic and EEG components of the orienting reaction elicited by an auditory stimulus was performed in 66 epileptics with therapy-resistant partial seizures (TRPS) and in 135 matched subjects in two control groups. The study showed a significant interictal hyperresponsivity in epileptics with TRPS vs. the normal subjects of control group I, which consisted in a marked increase of the intensity of the orienting reaction components. This hyperresponsivity was also more marked than that noted in epileptics with therapy-controlled partial seizures of control group II. The correlational analysis of data showed that the severity of these responsiveness disturbances in epileptics with TRPS depended on the patients' age, type of electroclinical seizures, pretrial seizure frequency, type of resting EEG, administered treatment (no. of administered antiepileptic drugs/patient), daily dose, as well as on the serum level of these drugs. The multivariate regression analysis showed that the most significant predictive variables for the responsiveness disturbances were the pretrial seizure frequency, type of electroclinical seizures, daily dose of administered antiepileptic drugs and their serum level. The data also evidenced that the antiepileptic treatment improves the interictal responsiveness disturbances, the effect being the more marked as the treatment was more sustained. The above-mentioned responsiveness changes in epileptics with TRPS should be ascribed to some disturbances in nervous excitability.

Acoustic Stimulation↗

PubMedDate not supplied

Diagnostic value of computerized EEG topographic analysis in epilepsy (preliminary data).

A computerized EEG topographic analysis (CETA) was carried out in 69 epileptics in order to evaluate the diagnostic value of such an investigation compared to that of the routine interictal EEG. The spectral frequency analysis of the bioelectrical activity in these patients was accomplished both by the fast Fourier transform and by the autoregression method. The obtained data were used for the spatial analysis of the electrical activity which was performed both by the interhemispheric coherence technique and by the color-coded topographic mapping in frequency bands. The data analysis showed that in 58 (84.1%) of the epileptics in whom routine EEG evidenced focal interictal bioelectrical abnormalities CETA also showed such abnormalities. However, CETA revealed focal abnormalities also in 8 (72.7%) out of the 11 epileptics in whom interictal EEG was interpreted as normal. The data analysis also showed that CETA was more efficient than EEG in the detection of focal abnormalities in the epilepsy with slow graphic elements, in the partial epilepsy, in the epilepsy with late onset and in the therapy-resistant epilepsy. The focal abnormalities evidenced by CETA were more expanded than those evidenced by routine EEG and the topographic maps indicated the focal involvement of a significant number of frequency bands. Considering the results, the authors make some appreciation regarding the diagnostic values of CETA in epilepsy.

Adolescent↗

PubMedDate not supplied

The therapy by ischemic stress induces a durable EEG synchronization in alpha frequency band.

The effect of forearm or calf ischemia on computerized EEG was studied in five patients with peripheral nervous system affections and five patients with cerebral infarction. Spatial analysis of power spectra in various frequency bands was performed in two 8-sec epochs, the former before ischemia and the latter after 5-min from the cessation of circulatory arrest which lasted 15 min. Transient peripheral ischemia resulted in consistent augmentation of alpha activity involving both the anterior and the posterior hemispheric areas, bilaterally. On the other hand, the slower frequency bands (theta, delta) underwent minor, nonsignificant alterations after ischemic stress. The rise of alpha amplitude induced by ischemic stress was ascribed to the activation of nonspecific thalamic system. The activation of this system might also be involved in the favourable effects exerted by ischemic stress on motor recovery of paretic limbs.

Adult↗