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Biomedical subjects

R Rokicka-Milewska

Publications and source records attributed to R Rokicka-Milewska.

At least 91 records · Page 5Linked to original sources
PubMed1983

Deficiency of short-lived suppressor cells controlling T-lymphocyte colony formation in acute lymphoblastic leukemia.

Short-lived suppressor cell (SLSC) activity controlling T-lymphocyte colony formation in vitro was evaluated in patients with acute lymphoblastic leukemia (ALL). No SLSC activity was found in patients in acute phase of the disease. On the other hand, patients in remission frequently had higher SLSC activity than controls. No correlation between colony count and thymidine incorporation as well as T-cell numbers was found in ALL patients.

Adolescent↗
PubMed1979

Clonal proliferation of lymphoid and myeloid progenitor cells in patients with hematological abnormalities.

Myeloid and lymphoid stem cell colony formation (GM-CFU) and L-CFU) was studied in patients with lymphoproliferative diseases, aplastic anemia and other hematological abnormalities. Most patients with acute lymphatic leukemia had low number of L-CFU with decreased or normal GM-CFU, while in Hodgkin's disease and chronic lymphatic leukemia L-CFU growth was very poor with only minor abnormalities of GM-CFU formation. Aplastic anemia was characterized by a decreased GM-CFU and normal L-CFU. Coculture studies suggested that a diminished colony formation may be linked to circulating lymphocytes that inhibit L-CFU as well as the reduction in number of precursor cells.

Adult↗
PubMed1976

Autoimmune haemolytic anaemia in children.

Forty-four children with autoimmune haemolytic anaemia (AIHA) are described: 31 had acute, subacute or chronic disease with warm autoantibodies and 13 had acute or chronic anaemia with cold autoantibodies. The commonest forms were the acute and subacute types with warm autoantibodies and these were more frequent in young children, while chronic AIHA occurred mainly among children at puberty. In about 16% the anaemia was accompanied by a chronic disorder but in over 50% the anaemia was preceded by an acute infection or immunization. The former gave rise mainly to chronic anaemia, but the latter was associated with the acute and subacute forms. In general the prognosis was good and death was never caused by anaemia per se. The prognosis was worse in patientw with clinical features of thrombocytopenia and bleeding and with the immunological findings of free autoantibodies in the serum and a positive direct antiglobulin test. In acute and subacute forms, treatment with corticosteroids and sometimes with blood transfusions was effective. In chronic forms of the disease it was often necessary to give additional immunosuppressive drugs or/and to perform a splenectomy.

Acute Disease↗