Biomedical subjects

R Rompel

Publications and source records attributed to R Rompel.

9 recordsLinked to original sources

PubMed1995

Human leukocyte antigens and multiple basal cell carcinomas.

This study presents data on human leukocyte antigen (HLA) phenotypes of 49 unrelated patients with multiple basal cell carcinomas (five or more BCC). Previous investigators noted an association with HLA-DR1 and a negative association with HLA-DR4. However, the previously found association was weak. HLA typing for class I (HLA-A, -B, -C) and class II antigens (HLA-DR, -DQ) was done from acid citrate dextrose (ACD)-stabilized peripheral blood using the modified lymphocytotoxicity test after T/B cell separation by immunobeads. Antigen frequencies of the patient group were compared to those of healthy individuals of a local German population (n = 716). Chi-square test and Fisher's exact test were used for statistical evaluation. While a significant association with HLA-DR1 was not observed in our study, we were able to confirm a significant decrease of HLA-DR4 in the patient group (12.2% versus 25.1%; p < 0.05; relative risk, RR, 0.48). In addition, HLA-Cw7 was significantly increased in the patient group (61.2% versus 40.8%; p < 0.01; RR, 2.29). In a subgroup of patients with multiple BCC located on the trunk (n = 25), the negative association with HLA-DR4 was even stronger (4% versus 25.1%; p < 0.02; RR, 0.12), whereas HLA-Cw7 was not significant (60.0% versus 40.8%; p = 0.06). Our results showed decreased frequencies of HLA-DR4 and increased frequencies of HLA-Cw7 in cases of multiple BCC, although statistical evaluation revealed only a weak association. This might be due to possible heterogeneity in this disease, e.g., BCC of the trunk versus BCC of the face, or any other cofactors.(ABSTRACT TRUNCATED AT 250 WORDS)

Antigens, Neoplasm↗

PubMed1995

Role of elective lymph node dissection in stage I malignant melanoma: evaluation by matched pair analysis.

The role of elective lymph node dissection (ELND) in clinical stage I malignant melanoma continues to be controversial. We present a matched pair analysis of 375 patients treated in the Department of Dermatology in Kassel between 1979 and 1991 by wide local excision (WLE) plus ELND. Multivariate analysis revealed tumor thickness, level of invasion, age, sex, and localization as independent prognostic factors, and 375 patients treated by WLE alone were matched as controls to the patients treated by ELND and WLE. There was no significant benefit from WLE plus ELND compared to WLE alone in the total group as shown by the 5-year survival rates (87.3% versus 86.4%) and 10-year survival rates (80.1% versus 77.82%). Increased survival rates were noted for tumor thicknesses 1.51-4.0 mm for the WLE plus ELND group, as shown by the 10-year survival rates of 73.1% versus 60.3%. However, these data were not significant (p = 0.14). Disease-free survival rates were significantly higher in the group treated by additional ELND for all tumor thicknesses (p < 0.05) and even more in intermediate tumor thicknesses of 1.51-4.0 mm (p < 0.001). A significant benefit of elective lymph node dissection was detected for malignant melanoma of the trunk (all tumor thicknesses), as shown by the 5-year survival rates of 92.0% versus 79.7% and 10-year survival rates of 80.4% versus 45.16% (p < 0.05). Malignant melanoma of the extremities revealed no significant differences in survival rates. We conclude that there is a certain benefit from ELND in clinical stage I malignant melanoma for tumor thicknesses of 1.51-4.00 mm. Especially in malignant melanoma of the trunk, WLE plus ELND was more beneficious than WLE alone.

Actuarial Analysis↗

PubMed1995

Elective lymph node dissection in primary malignant melanoma: a matched-pair analysis.

The role of elective lymph node dissection (ELND) in primary malignant melanoma is still controversial. Our purpose in this study was to evaluate the benefit from ELND on survival and disease-free survival in malignant melanoma of the trunk and extremities. We performed a matched-pair analysis on 750 patients. There was no significant benefit from wide local excision (WLE) plus ELND compared with WLE in the total group. Increased survival rates were noted for tumour thicknesses of 1.51-4.0 mm for the WLE+ELND group, as shown by 10-year survival rates of 73.1% vs 60.3% (p = 0.14). A significant benefit of ELND was detected for malignant melanoma of the trunk (p < 0.05). Disease-free survival rates were significantly higher in the collective treated by additional ELND for all tumour thicknesses (p < 0.05) and even more in intermediate tumour thicknesses of 1.51-4.0 mm (p < 0.001). Our data give further support that ELND may be valuable in improving the prognosis in case of malignant melanoma of intermediate Breslow thickness.

Adult↗

PubMed1994

[Status of surgical dermatology in the hospital and general practice].

Dermatosurgery has been gaining in importance in recent years. In departments of dermatology German-speaking countries the total number of operations increased by 58% from 1984 to 1991. The increase in the number of operations of moderate and extreme severity was especially marked. Out-patient dermatosurgery was also performed mainly by dermatologists as opposed to other specialties. From 1988 to 1992 dermatologists in private practice recorded an increase of 40.6% in the number of operative procedures they performed. The importance of dermatosurgery in hospital and private practice can be expected to continue increasing in the future; dermatologists must therefore prepare themselves for the present and future challenges inherent in surgery of the skin.

Ambulatory Surgical Procedures↗

PubMed1994

HLA phenotypes and multiple basal cell carcinomas.

BACKGROUND: Previous investigators noted an association of multiple basal cell carcinomas (BCC) with certain HLA antigens; however, these findings were contradictory, and the associations were only weak. OBJECTIVE: The aim of the study was to objectify the previously found associations. METHODS: Serologic HLA typing for class I and class II antigens was performed in 49 unrelated patients with 5 or more BCCs. RESULTS: HLA-DR4 showed decreased frequencies in the patient group as compared with healthy controls (n = 716). Cw7 was found to be increased in the total group of patients as well as in a subgroup with multiple BCCs of the face (n = 24), while a subgroup with BCCs mainly on the trunk (n = 25) revealed increased frequencies of HLA-A11, -B17, -B22 and -Cw3. However, none of these deviations appeared significant after correction of p values. CONCLUSION: We conclude that, if at all, the HLA system plays only a minor role in the development of multiple BCCs.

Adult↗

PubMed1994

HLA antigens in Peyronie's disease.

This study presents data on HLA phenotypes of 52 unrelated patients suffering from idiopathic Peyronie's disease. This first investigation on HLA class II antigens detected an association of HLA-DR3 and -DQw2 in this disorder. HLA typing was done from ACD-stabilized peripheral blood using the modified lymphocytotoxicity test. Antigen frequencies of the patient group were compared with those of healthy individuals of the local population. There were no deviations of frequencies for antigens of the B7 cross-reacting group as described in earlier studies. In addition none of the other class I antigens (HLA-A, -B, -C) showed any significant deviation in frequencies after correction of p values. Regarding class II antigens HLA-DR3 was detected in the patient group in 33.3% compared with 16.0% of the control population (corrected p < 0.05). The closely linked antigen DQw2 was found in 58.8 compared with 31.2% (corrected p < 0.005). Not only genetic factors can be stated by these findings. As HLA-DR3 and -DQw2 are known to be the typical associated antigens of organospecific autoimmune disorders, this suggests possible autoimmunological factors in this disorder of otherwise unknown etiology.

Autoimmune Diseases↗

PubMed1993

[Variations of the ultrasound image in malignant melanoma].

High-resolution ultrasound plays an important role in the preoperative assessment of malignant melanoma. The typical ultrasonographic image showing few internal echoes and sharp delineation allows statements on the benign or malignant nature and on tumour thickness. Diagnostic pitfalls are encountered if deviations from the typical structure are present, as they are caused by underlying dermal naevi, lymphocytic infiltration, or hair follicles. We describe variations in the ultrasonic imaging of malignant melanoma with reference to three cases.

Adult↗

PubMed1993

[Cerebriform intradermal nevus].

A case is reported of an extended cerebriform intradermal naevus of the scalp. Additional skin findings were generalized small intradermal and compound-type naevi. There were no neurological or other internal anomalies.

Adult↗

PubMed1991

HLA association of idiopathic Peyronie's disease: an indication of autoimmune phenomena in etiopathogenesis?

HLA typing for class I and class II antigens was done in 52 unrelated patients suffering from idiopathic Peyronie's disease. The controversially discussed association with the HLA-B7 cross-reacting group could not be confirmed. Marked deviations of antigen frequencies were observed for HLA-A1, B8, Cw7, DR3 and DQw2 compared to healthy local controls. After correction of p-values, A1 (pc less than 0.05) and DQw2 (pc less than 0.01) remained significant. A possible association of Peyronie's disease with markers of the HLA-A1, B8, Cw7, DR3, DQw2 haplotype, as first described here, would suggest autoimmunological factors in this disorder of otherwise unknown etiopathogenesis.

Adult↗