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Biomedical subjects

R Rose

Publications and source records attributed to R Rose.

98 records · Page 6Linked to original sources
PubMedDate not supplied

Cerebrospinal fluid cytokine levels after surgery with spinal or general anesthesia.

BACKGROUND AND OBJECTIVES: Studies show that pain may cause neuroinflammatory changes in the spinal cord. These inflammatory changes could be caused by circulating factors such as plasma cytokines or could be a primary neuroimmune response of the central nervous system following peripheral nerve injury. To identify the possible effects of peripheral trauma and pain on the cytokine environment of the spinal cord, interleukin-6 (IL-6) and interleukin-10 (IL-10) concentrations in plasma and cerebrospinal fluid (CSF) were measured before and after hip replacement surgery. METHODS: The investigation used a prospective, observational design to measure cytokine levels in samples of plasma and CSF by enzyme-linked immunosorbent assay (ELISA). Samples were taken from surgical patients before and after surgery under general anesthesia or spinal anesthesia performed with or without a spinal catheter. Reference samples were also obtained from healthy control subjects. RESULTS: Both plasma and CSF levels of IL-6 increased substantially after major surgery with either general or spinal anesthesia. No significant correlation was observed between plasma IL-6 and CSF IL-6 levels, suggesting a central origin for increased CSF cytokine levels. IL-10 did not change in plasma or CSF after surgery. Plasma and CSF IL-6 and IL-10 cytokine levels were very low or undetectable in healthy controls. CONCLUSIONS: Major orthopedic surgery leads to elevated CSF levels of the proinflammatory cytokine, IL-6. The origin of increased CSF IL-6 may be central because there was no significant correlation with plasma levels.

Anesthesia, General↗
PubMedDate not supplied

Use of the domestic Swine as an alternative animal model for conducting dermal irritation/corrosion studies on fatty amine ethoxylates.

The dermal irritation/corrosion potential of four fatty amine ethoxylates was evaluated using domestic swine as an alternative animal model. The weanling pig was chosen for this study due to the similarity of its skin to human skin with respect to structure and physiology. The four products, Armostat 310 (tallow bis (2-hydroxyethyl) amine), Armostat 410 (coco bis (2-hydroxyethyl) amine), Armostat 710 (oleyl bis (2-hydroxyethyl) amine), and Armostat 1800 (stearyl bis (2-hydroxyethyl) amine) were applied to the skin of three domestic swine for 4 hours in accordance with internationally accepted guidelines. Dermal reactions were scored up to 168 hours post application. Armostat 310, Armostat 410, and Armostat 710 were all classified as moderately irritating, whereas Armostat 1800 was nonirritating. None of the additives were corrosive to the skin of domestic swine. These products had been previously classified as corrosive based on studies conducted with rabbits using Armostat 310. This study demonstrates that the use of a more appropriate animal model will generate data that are relevant to humans for the classification of the potential dermal irritation and/or corrosive properties of chemicals.

Administration, Cutaneous↗
PubMedDate not supplied

A peritoneovenous shunt with an access port enables non surgical reversal of intraperitoneal catheter occlusion.

Management of chronic peritoneal ascites by transfer of the fluid to the right atrium via peritoneovenous shunt (PVS) is often complicated by occlusion of the peritoneal catheter by one, or a combination, of the following: 1) omental plugging of drain holes, 2) fibrin obstruction of the lumen, and 3) encapsulation of the peritoneal segment by a cocoon. A PVS design that includes an access port facilitates the reversal of fibrin obstruction by urokinase. Eight dogs with implanted PVS were tested weekly for patency (indicated by the flow rate of saline into the peritoneum via the access port) and performance (indicated by the percent transfer of saline from the peritoneum to the vasculature). In 256 test sessions performed to date, 15 catheter occlusions occurred. Nine of these were reversed by one or two flushes with 5,000 units of urokinase via the access port. The remaining six were found to be occluded by cocoons (two), omentum (three), and fibrin (one). Although it is an effective treatment for ascites, the PVS is not in common use, because it has a relatively high occlusion rate. The access port and other features of the authors' PVS are designed to reduce the incidence of PVS occlusion.

Animals↗
PubMedDate not supplied

Pediatric leg length discrepancy: causes and treatments.

Leg length discrepancies have multiple causes with a number of treatment options available to accomplish a goal of equal or near equal leg lengths at skeletal maturity. The management of a deformity in the lower extremity can be a complex undertaking requiring the skill and expertise of a multidisciplinary health care team. The purpose of this article is to provide an overview of how a treatment plan is formulated after careful evaluation through ongoing assessment, diagnosis, treatment, and follow-up. The plan of care needs to fit the needs of the child and those of the family through realistic goal setting, ongoing teaching, and support.

Artificial Limbs↗
PubMedDate not supplied

A simple portable ocular light device for phototherapy of seasonal affective disorder.

The authors report the development and a safety and acceptability study of a portable ocular light device, the SADlite. The study was conducted in 15 adult patients who had seasonal affective disorder (SAD). Each patient was given three two-week "on" phototherapy periods alternating with three two-week "off" periods. The SADlite provides 8,000 lux. Thirteen (13) of the 15 patients were completers and, as a group, achieved impressive clinical and statistically significant improvement (p < 0.0001) on three standard outcome measures. The SADlite was well tolerated, produced no adverse visual effect, and was preferred by patients previously exposed to stationary phototherapy devices.

Adult↗