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R Roselli

Publications and source records attributed to R Roselli.

44 records · Page 3Linked to original sources
PubMedDate not supplied

New perspectives in brachycurietherapy of malignant brain tumors. Preliminary report.

Between 1980 and 1988, 16 patients (9 females, 7 males) with malignant neuroepithelial tumors of the brain were treated by brachycurietherapy (BCT) and external radiation therapy (ERT) in a phase II nonrandomized study. There were 13 grade III and 3 grade IV tumors according to the WHO classification. Five patients in the grade III group who showed anaplastic foci in a generally grade II background were separately examined. Six patients received only BCT whereas 10 patients were treated by a combination of BCT and ERT, according to the tumor volume. We utilized as radioactive sources 192Ir in 14 cases and 125I in 2. Thirteen patients underwent permanent implant, 3 others received temporary irradiation with removable afterloaded catheters. The target volume was less than 50 cc in 8 cases, between 50 and 100 cc in 7, and larger than 100 cc in 1 patient. The total dose at the periphery of these volume ranged between 70 and 144 Gy. The result were analyzed referring to the following aspects: performance status, survival, side effects, grading. The impact of BCT was analyzed especially in a grade III with anaplastic foci group which showed a median survival of 6 years compared with only 2 years median survival of the pure grade III group.

Brachytherapy↗
PubMedDate not supplied

The progression in astrocytic tumors.

Progression represents the qualitative tumor evolution during the time. Recently it received great consideration, mainly since the introduction of the neuroradiological imaging (CT and MRI). A series of 224 supratentorial astrocytic tumors of the juvenile and adult age have been analyzed: we found the morphological features of progression in 26% of them. These data introduce, perhaps, the most important information about progression: the "crisis" of the concept that low-grade tumors are stable lesions during the time.

Astrocytoma↗
PubMedDate not supplied

Indications of stereotactic biopsy.

Stereotactic biopsy is nowadays considered a diagnostic procedure indispensable for anyone dealing with neuro-oncology, though its role is still debated especially in comparison with the one of the direct surgical approach. The Authors examine the indications of stereotactic biopsy in the management of intracranial expanding lesions, reviewing their personal series of 793 cases surgically treated in the last 7 years; of these, 210 underwent stereobiopsy. The possibilities of the procedure, its reliability as well as the possible complications are analysed in detail. Finally, the crucial role played by the pathological examination in the diagnosis of neoplasia is particularly stressed.

Biopsy↗
PubMedDate not supplied

Possibilities and limits of brachycurietherapy in brain tumors.

Brachicurietherapy represents a low dose-rate irradiation able to deliver high focal doses within relatively small tumor volumes. Its application to brain tumors utilizing the stereotactic techniques is nowadays considered with growing interest. The Authors analyze, on the basis of their personal experience, the possibilities and the limits offered by this therapeutic procedure in neuro-oncology. The choice of the sources and their modality of application, the definition of the optimal dose/time and dose/volume ratio are the main problems taken into consideration and discussed.

Adult↗
PubMedDate not supplied

Some differences in steroid receptors between meningeal and neuroepithelial tumors.

In our study we evaluated the presence of steroid hormone receptors in a large series of endocranial tumors and investigated the possible correlations between receptor presence and levels and patient's age and sex. Our data indicate that steroid receptor behavior in the neoplasias considered is quite different from that observed in endocrine-related tumors, such as breast and endometrial cancer. Moreover, in neuroepithelial tumors an interesting difference between male and female subjects has been found regarding the receptor distribution in poor differentiated neoplasias.

Adolescent↗
PubMedDate not supplied

[Combined craniofacial surgery in malignant tumors of the ethmoid].

The Authors discuss the importance of surgical treatment in ethmoid cancer basing their discussion upon observation of three cases involving the anterior skull base which followed an overview of the epidemiology, histology and evaluation of this kind of pathology. After reviewing Literature they stress the validity of anterior craniofacial resection which allows a wide exposure of the complex anatomic structures at the base of the skull and a monoblock resection of malignant tumors as well as a satisfactory reconstruction of the resulting defect at the skull base. Furthermore, they emphasize the still existing differences among many Authors as far as surgical technique is concerned and the extreme variability of the survival rate. The Authors conclude that in order to make a comparison between the results of different Authors, data concerning the site of origin, the extension and the histology of the tumors and the length of the follow-up should be more homogeneous.

Aged↗
PubMedDate not supplied

Intraoperative real-time ultrasonography in the microsurgical removal of subcortical or deep-seated brain tumors.

Seventy-three patients with subcortical or deep-seated brain tumours have been operated on with the aid of intraoperative ultrasonography. Forty-one had metastases and thirty-two primitive neuroepithelial neoplasms. In all cases ultrasonography allowed an easy and precise localization of the tumours. The removal was gross total in 45 cases (61.6 per cent), subtotal in 17 (23.3 per cent) and partial in 11 (15.1 per cent). Preservation or improvement of the Karnofsky Performance Status was obtained in 63 patients (86.3 per cent), with a morbidity and mortality rate of 11 and 2.7 per cent respectively. Our results indicate that ultrasound guided microsurgery represents a handy, reliable and relatively low risk procedure for the treatment of intra-axial brain tumours.

Brain Neoplasms↗