Cushing's syndrome after topical application of corticosteroids.
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Biomedical subjects
Publications and source records attributed to R Ruiz-Maldonado.
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The frequency of genito-crural candidiasis in infants presenting diaper rash, as well as the possible influence of bacterial flora in this region on the pathogenicity of Candida was studied. Skin scraping were made with sterile swabs and processed by bacteriological and mycological methods in 140 children whose ages ranged between 0 and 20 months. The most commonly found microbiological flora were Candida spp (65.7%), non hemolytic Streptococcus (18.5%), Staphylococus epidermidis (19.2%); beta hemolytic Streptococcus (12.8%) and alfa-hemolytic Streptococcus (9.2%). Of the 140 cases, 76 (54.3%) showed candidiasis associated with diaper rash and 16 (11.4%) had Candida as normal flora. C. albicans was most frequently found (66.3%) followed by C. tropicalis (19.6%). Candidiasis was more frequent in those infants that had no other associated of pathogenic flora. Factors significantly influencing the increase in the frequency of candidiasis were: A) Evolution time, which was directly proportional; B) Use of cotton diapers covered with plastic pants; C) Feeding with cow's as opposed to maternal milk; and D) Malnutrition associated with poor hygiene.
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Seventeen children with clinical and histological diagnosis at lichen nitidus are reported. An incidence of one case for every 882 pediatric dermatology patients was found. LN predominated in males in a 3:1 relation. The lesions usually first appeared during infancy as grouped skin colored micropapules with shiny surface. The trunk and upper limbs were the most frequently affected body segments. The histological picture was diagnostic showing a local ganulomatous infiltrate in the papillary dermis in between two rate pages and in close contact with the epidermis. No effective treatment is known. The lesions spontaneously disappeared in an average time of 18 months.
8 children with lamellar ichthyosis, 1 with epidermolytic hyperkeratosis and 5 with symmetrical progressive erythrokeratoderma were treated with a new aromatic retinoid (Ro 10-9359). Clinical improvement was dramatic. The children acquired an appearance never obtained before with other managements. The treatment had to be maintained to prevent recurrence. The tolerance to the drug was good. The side-effects were minimal and tended to disappear after several months of treatment. Our results suggest that because of its efficacy, good tolerance and easy administration, the oral retinoid Ro 10-9359 is at present the treatment of choice for the great ichthyotic disorders of children.
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A Mexican child was born white and progressively became black. At the age of 21 months, the whole integument was deep black in the absence of other alterations. Electron microscopy showed a Negroid pattern in the epidermal melanosomes. Among the different forms of progressive mucocutaneous pigmentations previously described in the literature, we were unable to find a similar case.
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A 2-year-old Mexican girl had hypochromic lesions characteristic of incontinentia pigmenti achromians on the right half of the body. Extra cutaneous alterations were: dacryostenosis, bilateral genu valgus,ataxic gait, language retardation, hydrocephaly and abnormal electroencephalogram. Electron microscopy showed numerous Langerhans cells in the epidermis.
An 11-year-old boy with typical lesions of pachyonychia congenita (Jadassohn-Lewandowsky) type II and with keratotic lesions histologically characteristic of Kyrle's Disease is described.
The case is presented of a 3-year-old girl with urticaria and pressure dermographism. The condition began the age of one year. A skin biopsy confirmed the suspected diagnosis of diffuse mastocytosis. The identification of the form of mastocytosis without skin lesions and with dermographism and pressure urticaria as its only signs is important. It should be considered in any chronic urticaria appearing at birth or in an early age which is unresponsive to the usual symptomatic medication.
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