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Biomedical subjects

R Rutkowski

Publications and source records attributed to R Rutkowski.

17 recordsLinked to original sources

[Paradoxic bronchial constriction after inhalation of fenoterol and ipratropium bromide].

Two cases of paradoxic bronchial constriction after inhalation of fenoterol and ipratropium bromide are presented. Both patients had bronchial asthma. In the first case the inhalation of fenoterol produced dyspnea and a decrease of FEV1 and FEF25-75. In the second similar observations were made after inhalation of ipratropium bromide. The above mentioned observations illustrate the risk of drug related paradoxic reactions, especially in atopic patients.

Administration, Inhalation

[Effect of ketotifen, nedocromil sodium and budesonide on non-specific bronchial hyperreactivity to histamine in patients with asthma].

The aim of the study was to evaluate the effect of ketotifen, nedocromil sodium and budesonide on non-specific bronchial hyperreactivity in asthmatic patients. The study was performed on a group of 40 patients treated with these drugs for a period of 4-12 weeks. Bronchial provocation with histamine was carried out in all patients before and after therapy. In subjects receiving ketotifen an additional provocation test was performed 3 days and 4 weeks after commencement of treatment. The results showed that drugs inhibiting the release of mediators from mast cells or diminishing the late phase of bronchial allergic reaction significantly reduce non-specific bronchial hyperreactivity.

Adult

Relief of patellofemoral contact stress by anterior displacement of the tibial tubercle.

Elevation of the patellar tendon by means of displacement of the tibial tubercle has been advocated by Maquet, Ficat and Hungerford, and Murray as an alternative to patellectomy for the treatment of patellofemoral arthralgias. Although tubercle elevation certainly reduces the over-all patellofemoral contact force, its effects on the complex local patterns of contact stress are of more direct significance. In a laboratory series using fresh amputation material, arrays of six miniature contact stress sensors were embedded in the retropatellar cartilage of knees subjected to isometric quadriceps-extension forces. The experimental data revealed that elevation of the patellar tendon generally afforded relief of local contact stress regardless of the joint configuration (zero degrees, 45 degrees, or 90 degrees of flexion), but that its effects were most pronounced at 90 degrees of flexion. Progressive increase in the tendon elevation caused progressive reduction in the contact stress. Most of the contact stress relief was achieved, however, with the first one-half inch of tendon elevation; further elevations to one and one and one-half inches were only marginally useful. In view of the increased superior patellar pole contact associated with distal pole flotation, the results indicate that under most circumstances the optimum amount of elevation of the tibial tubercle is about one-half inch.

Cartilage, Articular

Ferrographic analysis of wear particles in arthroplastic joints.

Analysis of aspirated synovial fluid appears to be a useful method for the study of the rates, mechanisms, and biological responses to wear in surgical joint replacements. Ferrography, an industrial technique of magnetic separation of particulate matter from samples of lubricating solutions, allows separation of wear debris from synovial fluid. Bichromatic microscopy and SEM X-ray analysis permit identification of metallic particles from arthroplastic joints. Polarized light microscopy characterizes and differentiates polyethylene and polymethacrylate debris. The number and morphology of the wear particles in synovial specimens from arthroplastic joints correlate with the rate and the mechanisms of wear, as confirmed by examination of the implant and the adjacent synovial tissue.

Color

Experimental fracture healing: evaluation using radionuclide bone imaging: concise communication.

Radionuclide bone imaging was performed in a rabbit model to observe the course of fracture healing and to establish criteria for distinguishing nonunion and delayed healing from normal healing. Sequential gamma-camera images (with pinhole collimator) were collected and subjected to computer analysis. Five groups were established: a) control--immobilization; b) control--immobilization plus periosteal stripping; c) simple fracture--osteotomy; d) delayed union--osteotomy plus periosteal stripping; and e) nonunion--osteotomy, periosteal stripping and polymethyl methacrylate interposed between fracture fragments. Histographic representation of absolute count rates along rabbit tibias followed a predictable pattern in the simple-fracture and delayed-union groups. They differed only in the time of appearance of phases. The nonunion group demonstrated no recognizable sequential pattern. In this experimental model, serial bone scanning with quantitative data analysis has shown potential for indicating the course of healing in fractures and for serving as a guide to treatment.

Animals

[A study of involuntary treatment in psychiatric hospitals].

Research revealed that the only documented form of forced treatment was the use of mechanical restraining of patients. The frequency and circumstances of restraining patients were highly dependent on, among others, the structure of employment of hospital personnel. Research was conducted on 6962 patients from 6 psychiatric hospitals. It was revealed that during a month mechanical restraint was used with 5.5% of the patients. This percentage wavered from 1.6% to 8% in different hospitals. Isolation was not used at all. The frequency and circumstances of using force was significantly related to age, sex, marital status, the length of hospitalization and the diagnosis of the patient. Furthermore, the number of staff and the structure of employment in particular hospitals was important.

Female