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Biomedical subjects

R Ruvidić

Publications and source records attributed to R Ruvidić.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Erythropoietin in sideropenic anemias].

The erythropoietic activity in the sera of 18 patients with sideropenic anemia was investigated. The ex-hypoxic mouse bioassay was used and the 48 hour incorporation of radioiron into the peripheral blood was measured. The level of erythropoietin found was compared to the hemoglobin concentration and the PCV values in those patients. The statistically significant correlation was found between erythropoietin in the patients sera and the degree of anemia. Higher erythropoietin values were found in men as compared to women with the same severity of anemia. It was concluded that the results obtained in this study can be used as control values when erythropoietic activity in the sera of patients with different hematological disorders is measured.

Adult↗
PubMed1977

Cell cycle time of erythroid cells in mice with normal and stimulated erythropoiesis.

The cell cycle time of erythroid cells was determined in normal mice and in polycythaemic mice after stimulation of erythropoiesis by exogenous erythropoietin. The method employed was 3HTdR autoradiography of bone marrow cells. After 21 or 38 hours of administratering the erythropoietin 3HTdR was injected into the animals. The cell cycle time was calculated from the curves of changes in the labelling indices of proerythroblasts and basophilic erythroblasts at one hour intervals. The cell cycle time in normal animals was 8.5 hours. Twenty-two to twenty-five hours after stimulation with 1.5 units of erythropoietin, the cell cycle was 7.8 hours. Thirty-nine to forty-two hours after injection, at the time when the number of nucleated erythroid cells was within normal limits, the cell cycle time was 7.7 hours. Under the used experimental conditions, the cell cycle time of early erythroid cells was not significantly changed in comparison with the values obtained in non-treated animals. This is in contrast to the results reported when extreme stimulation of erythropoiesis with endogenous erythropoietin was used.

Animals↗
PubMed1976

[Results in the treatment of acute leukemias at the Internal Clinic B in the period 1970-1975].

Results of the treatment of 102 acute leukemia patients are presented. The diagnosis in 61 patients was acute myeloid leukemia (AML) and in 41 patients acute lymphoid leukemia (ALL). In the treatment of AML were used Daunorubicyne (DNR), Cytosine arabinoside (ARA-C) or combination of both drugs, some elder patients being treated with 6-mercapropurine. Number of patients were made aplastic and died during the initial phase of therapy. Nine of 24 patients treated with DNR, ARA-C or combined developed complete remission, 6 patients lived for one year and 4 patients two years. ALL patients were treated with Prednisone-Vincristine, Prednisone-Vincristine-DNR and some of them with Prednisone-Vincristine-DNR-Cyclophosphamide-L-Asparaginase combinations of drugs. Complete remission was obtained in 22 out of 32 patients (69%) and 6 patients lived for 2 years.

Cyclophosphamide↗
PubMed1975

Hemoglobin Beograd (alpha2beta2 121 Glu leads to Val) interacting with beta-thalassemia.

Hematological and biochemical findings in a family with hemoglobin (Hb) Beograd interacting with beta-thalassemia are presented. Hb Beograd (alpha2beta2 121 Gul leads to Val) was found in 3 members. In two members it interacted with beta-thalassemia. These two double heterozygotes had anemia of intermediate severity and splenomegaly. Studies with 51Cr and 59Fe showed a shortened life span of red cells and ineffective erythropoiesis. The abnormal Hb amounted to 86-87%, and Hb F to 5-7%. No Hb A was present. One subject of the family was heterozygous for Hb Beograd. He showed normal clinical and hematological findings. The abnormal hemoglobin was 38%. Four members of the family were heterozygotes for beta-thalassemia. The interaction between beta-thalassemia and beta-chain variants is discussed.

Adult↗
PubMed1975

[Postpartum hemorrhage syndrome caused by factor VIII inhibitor in the blood].

The appearance of Factor VIII inhibitor in women after childbirth is a very rare occurence. However the hemorrhagic syndrome which results from such condition can be very serious and difficult to treat. In this paper a case of young women is described who developed after childbirth a severe bleeding disorder. Clinical feature was very similar to those seen in haemophilia. The patient was investigated in the local hospital but the diagnosis was not made. The bleeding disorder lasted with various extension for six months and patient finally developed a severe sublingual and laringeal bleeding. She was transfered to the Clinic "B" of Internal Medicine in a very serious condition. On examination there was marked prolongation of the clotting time and no detectable Factor VIII. On the basis of these findings and the clinical expression of bleeding disorders, the tentative diagnosis of Factor VIII inhibitor was made. The treatment was not possible to institute because the patient expired within hours. Autopsy showed that bleeding into deep laringeal tissue was the sole cause of her death. Additional examination of the of the patient's plasma specimen using the antibody assay (Biggs-Bidwell-1959) showed the presence of the antibody to the Factor Viii which were active in 1:100 dilution.

Adult↗
PubMedDate not supplied

[Chronic lymphocytic leukemia complicated by pernicious anemia during long-term remission].

Chronic lymphocytic leukaemia was diagnosed in 1957 in a 29-year-old male patient who lived 31 years after that time. At the time of diagnosis he was in good general condition with the enlarged liver (4 cm) and spleen (5 cm). In peripheral blood the leukocyte count was 47 x 10(9)/1 with 80% lymphocytes (38 x 10(9)/1), Hb 106 g/1; the bone marrow showed hypercellularity with predominance of lymphocytes. Treatment with corticosteroids was during 1958-1966. In 1967 Chlorambucil was given for 3 months, in 1972 for one month, inducing normalization of leukocyte count, 5.7 x 10(9)/1 with 40-50% of lymphocytes (3 x 10(9)/1). In 1977 the bone marrow showed slight lymphocytosis (38%). Numerous infections were recorded. Splenomegaly disappeared in 1980. In 1982 macrocytic anaemia was observed. Diagnosis of pernicious anaemia was established based on megaloblastic bone marrow and positive Schilling test. Vitamin B12 treatment resulted in reticulocyte response (crisis) and normalization of haemoglobin level. In 1988 light anaemia and melena appeared. Gastroscopy revealed lesions in the fornix histologically identified as ventricular carcinoma. It can be presumed that the appearance of pernicious anaemia as an autoimmune disease is analogous to other autoimmune complications in chronic lymphocytic leukaemia (haemolytic anaemia, thrombocytopenia).

Adult↗