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Biomedical subjects

R Ryan

Publications and source records attributed to R Ryan.

At least 73 records · Page 4Linked to original sources
PubMed1992

Excitatory amino acid signal transduction in the hippocampus: role of noradrenergic afferents and nitric oxide in cGMP increases in vivo.

Previous studies have demonstrated that excitatory amino acid (EAA)-dependent increases in cerebellar cGMP are dependent upon the prior activation of nitric oxide (NO) synthase. Additionally, the actions of NMDA, but not kainate or quisqualate, in elevating cerebellar cGMP have been shown to be dependent upon intact noradrenergic innervation of the cerebellum. In the current study we extended these observations to the hippocampus and again found that EAA-dependent increases in hippocampal cGMP also involve prior formation of NO. And as in the case of the cerebellum, NMDA-dependent increases in hippocampal cGMP involve prior release of norepinephrine which in turn apparently activates an alpha 1-adrenergic receptor to elicit cGMP increases. In toto, these data suggest that a key role of NMDA receptors in these brain regions is to presynaptically regulate the release of norepinephrine, thereby modulating the tone of this monoaminergic system. This may be a general principle which needs experimentation in other terminal fields of noradrenergic pathways.

Analysis of Variance↗
PubMed1992

The morbidity from nasal splints in 105 patients.

The results of a randomized prospective trial investigating the morbidity from intranasal splints in 105 patients, were analysed. Intranasal splints are associated with considerable morbidity (significantly greater post-operative pain and a higher incidence of septal perforation and vestibulitis) and although they significantly reduce the likelihood of developing intranasal adhesions, a similar benefit can be obtained by careful nasal toilet at one week.

Adult↗
PubMed1992

Babesiosis: an underdiagnosed disease of children.

Babesiosis is a malaria-like illness caused by the intraerythrocytic parasite Babesia microti and is transmitted by the same tick that transmits Borrelia burgdorferi, the causative agent of Lyme disease. Babesiosis is well recognized in adult residents of southern New England and New York but has been described in only five children. To determine whether children are infected with B microti less often than are adults, a prospective serosurvey was carried out on Block Island, RI, where babesiosis is endemic. Randomly recruited subjects completed a questionnaire and provided a blood sample. Antibodies against B microti and B burgdorferi were measured using a standard indirect immunofluorescence assay and enzyme-linked immunosorbent assay, respectively. Of 574 subjects, 9% tested positive for B microti, including 12% of the 52 children (7 months through 16 years) and 8% of the 522 adults (not significant, P less than .6). Although babesiosis had not been diagnosed in any of the Babesia-seropositive subjects, 25% of the children and 20% of the adults reported symptoms compatible with this infection during the previous year. Of the 6 children and 45 adults seropositive for B burgdorferi, 17% and 14%, respectively, were also seropositive for B microti. It is concluded that children are infected with B microti no less frequently than are adults and that this infection is underdiagnosed in all age groups. Physicians who practice where Lyme disease is endemic should become familiar with the clinical presentation and diagnosis of babesiosis, both in adults and children.

Adolescent↗
PubMed1991

The miscarriage clinic: an audit of the first year.

We preview the results of the first year in a Miscarriage Clinic set up in 1989 in an effort to improve the support and counselling of women who have a miscarriage. Of 381 patients referred, 79% attended. The only statistically significant difference between the women who attended and those who did not attend was in the proportion of women who had planned their pregnancies (65% versus 33%, P less than 0.01). Of the 300 patients who attended, 4% reported no grief reaction; 75% experienced a reaction which had resolved within one month and 21% experienced a reaction which had not resolved. No factor was identified which could predict the duration of the grief reaction. This audit demonstrates that there is a strong demand and need for this service for couples who experience a miscarriage.

Abortion, Spontaneous↗
PubMed1991

Geographical and temporal distribution of babesial infection in Connecticut.

Human babesiosis was first recognized in Connecticut in 1989, nearly 15 years after Lyme disease, a similarly transmitted spirochetosis, was detected in the state. To determine the seroprevalence for the babesial pathogen and whether it was recently introduced, we used an indirect immunofluorescence assay to test for Babesia microti antibody in 1,285 Connecticut residents. Four groups were studied: I, people seropositive for Lyme disease, tested from 1986 to 1989; II, randomly selected outpatients tested in 1989; III, college students residing in Connecticut, tested from 1959 to 1989; and IV, healthy people without tick exposure or Lyme disease, tested in 1989. Babesia seropositivity was significantly higher in group I (9.5%; n = 735) than in groups II (2.6%; n = 304, P less than 0.0001) and III (1.0%; n = 206, P less than 0.0001) but not group IV (2.5%, n = 40). Babesia seropositivity for group I ranged from 9.2 to 10.2% between 1986 and 1989, and Babesia seropositivity for group III ranged from 0% between 1959 and 1985 to 2.9% between 1986 and 1989. There is a considerable risk of babesial infection among residents of the Connecticut mainland who are seropositive for Lyme disease, a risk that appears to have remained constant over the past 5 years.

Animals↗
PubMed1990

Factors related to job satisfaction and autonomy as correlates of potential job retention for rural nurses.

This study of 167 nurses in 10 rural Georgia agencies examines the relationships among personal characteristics, factors of job satisfaction, autonomy, and job retention. The findings indicate that, contrary to expectations, personal characteristics (e.g., age, education, salary, marital status, and number of dependents) are not strong predictors of job retention in this sample. Some of the factors of job satisfaction do correlate negatively with indicators of impending job change, but the strongest relationships were those related to nursing autonomy. The study concludes that, of the variables studied, autonomy was the most effective predictor of job satisfaction and intention to remain in the current position.

Decision Making, Organizational↗
PubMed1989

Spinal epidural abscess. An infectious emergency. Case report and review.

Spinal epidural abscess is an unusual disease in the pediatric age group, requires early diagnosis and prompt surgical drainage to insure a good clinical outcome. Back pain and fever are usually the only presenting symptoms occurring before precipitous neurologic deterioration. The causative organism is most often Staphylococcus aureus, which presumably is spread to the epidural space hematogenously. Diagnosis is facilitated by computed tomography (CT) scan, but the entire spine must be imaged by either myelography or magnetic resonance imaging (MRI) to assess for skip lesions.

Abscess↗
PubMed1989

Getting to the heart of rural EMS.

The Rural EMS Task Force was formed by the National Rural Health Association to investigate critical issues in the rural EMS response system. The task force felt that many issues were at play and should be investigated in the form of a survey to determine nationwide needs. The EMS Today Working Conference in March became a forum to address potential solutions to those needs. Much work remains to better conditions for volunteer personnel who are expected to meet greater and greater expectations with fewer and fewer resources.

Allied Health Personnel↗
PubMed1988

Recurrent tonsillitis and growth in children.

Anecdotal observations suggest an association between tonsil disease and growth retardation. This study compared height, weight and skinfold thickness measurements between a group of children (44) suffering from recurrent tonsillitis for a mean duration of 4 years, and a control group (34). No important differences were observed between the groups. Recurrent tonsil infection does not appear to retard the growth of children.

Body Height↗
PubMed1987

The effect of swimming in chlorinated water on middle ear pressure.

This study evaluated whether an important fall in middle ear pressure (MEP) was recordable several hours after swimming. MEPs were measured in 52 normal school children on an average of four occasions immediately before swimming and "control" exercise sessions, and were repeated four hours after the activity. Twenty-nine children swam in a high chlorine concentration, with a mean free chlorine level of 2.3 parts per million, and 23 children swam in a low chlorine environment, with a mean concentration of 0.4 parts per million. For the former there was an average decrease of 0.5 daPa after swimming and an increase of 34.7 daPa after exercise; for the latter there were increases of 13.3 and 15.6 daPa after swimming and exercise respectively. It is concluded that swimming does not adversely affect middle ear function. Exercise induces an increase in MEP, and exposure to high chlorine levels appears to cause a small reduction in middle ear pressure.

Child↗
PubMed1986

Education of health care providers for the rural setting: a family nurse practitioner demonstration program.

Spurred by mass concern over shortages of health care providers, the country's educational system has, over the past ten years, produced an ample supply (in some areas a near glut) of health care professionals. Studies demonstrate, however, that these professionals tend to cluster in the affluent metropolitan and suburban areas. Residents of rural areas are still significantly underserved. In the healthy rural southern half of Georgia, this problem has reached a critical peak. Georgia Southern College (GSC) is a rural based college located in the heart of rural south Georgia. In order to address some of the health care problems of its constituency, GSC, with federal support, established a Nursing Department and a Family Nurse Practitioner program with a commitment to recruit nursing students from the rural area, educate them in rural settings, and provide appropriate preparation for the unique experience of working in the rural environment. The program has been very successful in producing highly skilled graduates who do stay and work in the rural areas, providing health care at reasonable costs. This paper describes the setting (rural south Georgia), the need, the program implementation, and the impact (number of graduates actually working in rural settings, and innovative projects initiated by graduates).

Georgia↗