Scalp metastasis from glioblastoma.
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Brain Neoplasms↗
Biomedical subjects
R S Allan
Publications and source records attributed to R S Allan.
Capacitance cytometry: measuring biological cells one by one.
Measuring the DNA content of eukaryotic cells is a fundamental task in biology and medicine. We have observed a linear relationship between the DNA content of eukaryotic cells and the change in capacitance that is evoked by the passage of individual cells across a 1-kHz electric field. This relationship is species-independent; consequently, we have developed a microfluidic technique-"capacitance cytometry"-that can be used to quantify the DNA content of single eukaryotic cells and to analyze the cell-cycle kinetics of populations of cells. Comparisons with standard flow cytometry demonstrate the sensitivity of this new technique.
Animals↗
"Ute surfing": a novel cause of severe head injury.
Riding on the load tray of a moving utility vehicle, often after drinking alcohol, is a recognized pastime among young Australian men. The cases presented here show that associated accidents can result in serious head injuries and probable permanent neurological deficits.
Accidents, Traffic↗
"Rhabdoid meningioma" lacking malignant features. Report of two cases.
We report 2 cases of meningiomas with rhabdoid morphology but lacking histological features of malignancy. Both occurred in adult women, one arising from the superior surface of the tentorium and the other in the Sylvian fissure. The tumors showed light microscopic, immunohistochemical and ultrastructural evidence of meningothelial differentiation together with diffuse or focal areas exhibiting rhabdoid morphology. The rhabdoid areas were characterized by cells with large cytoplasmic eosinophilic inclusions and large eccentric nuclei. Both cases showed areas with sheet-like growth and one had macronucleoli and brain invasion. The same case showed areas of necrosis that most likely related to pre-operative arterial embolization. Unlike most cases reported in the literature, these "rhabdoid meningiomas" lacked significant mitotic activity or other atypical features. The diagnostic and prognostic significance of this tumor entity is discussed along with a review of the literature.
Adult↗