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Biomedical subjects

R S Barnetson

Publications and source records attributed to R S Barnetson.

At least 91 records · Page 5Linked to original sources
PubMed1983

Increased gliadin antibodies in dermatitis herpetiformis and pemphigoid.

The mean titres of serum IgG and IgA gliadin antibodies were significantly increased in thirty-four patients with bullous pemphigoid, and in twenty-three patients with dermatitis herpetiformis, compared with twenty-four healthy controls. The patients with pemphigoid also had increased IgG and IgA gliadin antibodies compared with nine patients with pemphigus. The reason for the high titres of gliadin antibodies in pemphigoid is obscure. These patients may have increased intestinal permeability (suggested by the presence of beta-lactoglobulin antibodies in some patients). Alternatively gliadin may somehow precipitate the autoimmune process.

Aged↗
PubMed1983

T-cell mediated immunity in food allergy.

There are many T-cells within the intestinal mucosa, and histopathology, applied to biopsies of intestinal mucosa taken before and after food reintroduction, provides information on possible cell-mediated immunity to foods within the gut. Food sensitive enteropathies occur in man and in domestic animals, particularly in the young. Our hypothesis is that these are related to a relative deficiency of suppressor T-cells. There is no evidence that T-cell-mediated immunity to foods plays a part in severe atopic eczema, even in patients with clinical evidence of associated food allergy and high titres of IgE antibodies to foods.

Adult↗
PubMed1983

A clinical and immunological study of four babies of mothers with lepromatous leprosy, two of whom developed leprosy in infancy.

One hundred thirteen women and 27 healthy controls were studied throughout pregnancy, at delivery, and followed up with their babies during lactation. Thirty-eight of the mothers with lepromatous leprosy were found to have solid-staining bacilli in skin smears or biopsies, and hence were considered potentially highly infectious to their unborn children by hematogenous spread via the placenta. Two babies of mothers within this group were diagnosed as having leprosy on clinical and histological grounds. A third baby could well have had leprosy, but the case was not proven. The fourth baby did not have leprosy and, although it did have ringworm, was thus deemed to be a reasonable control. The leprosy skin lesions were first observed at a special followup clinic when the children were between the aged of 9 and 17 months. The demonstration of IgA and IgM anti-M. leprae antibodies in cord sera was taken as an indication of intrauterine immunologic stimulation, and hence transplacental transmission of M. leprae. The two babies with proven leprosy showed an early and significant increase in serum IgA and in particular serum IgM anti-M. leprae antibody activity. A third baby, suspected of having leprosy but in whom the diagnosis was not proven, showed a similar but less marked increase in serum IgA and IgM activity. The fourth baby showed no such rise in anti-M. leprae activity. A decrease in serum IgG anti-M. leprae antibody activity could be demonstrated in one of the babies with leprosy after healing of the leprosy lesions, but not in the second baby.

Antibodies, Bacterial↗
PubMed1982

Thymic hypoplasia, auto-immune haemolytic anaemia and juvenile pemphigoid in an infant.

A female infant developed auto-immune haemolytic anaemia and juvenile pemphigoid, and died at the age of 10 months. Autopsy showed evidence of thymic hypoplasia and T lymphocyte deficiency. It was concluded that the two rare auto-immune diseases occurring in this child probably resulted from a lack of T cell regulation of antibody-producing B lymphocytes.

Anemia, Hemolytic, Autoimmune↗
PubMed1981

Studies on hyperimmunoglobulinaemia E in atopic diseases with particular reference to food allergens.

Total and specific IgE have been measured in serum, suction blister fluid and jejunal aspirate in patients with various atopic disorders in an attempt to increase our knowledge of the association between food allergy and adult atopic eczema. We found (a) that patients with atopic disorders, irrespective of whether the disease affects primarily the skin or airways, have raised IgE concentrations that are largely attributable to antibodies directed against inhaled allergens; (b) that IgE antibodies against food allergens account for an appreciable amount of the total IgE in patients with atopic eczema though not as much as that contributed by inhalants; and (c) that in patients with atopic eczema, most of the IgE is produced at sites other than the intestine or skin.

Adolescent↗
PubMed1978

Cutaneous leishmaniasis and leprosy.

Eight patients who had concomitant leprosy and leishmaniasis are described. Two patients with lepromatous leprosy had high resistance leishmaniasis, implying that the immune deficiency in lepromatous leprosy is specific to Mycobacterium leprae.

Adolescent↗
PubMed1978

A form of muco-cutaneous leishmaniasis in the Old World.

Four Ethiopian patients with leshmaniasis affecting the nose or the mouth are described. Leishmaniasis affecting these sites is relatively common in Ethiopia; this resembles South American leishmaniasis but probably results from direct extension from skin lesions rather than from metastatic spread of organisms.

Adolescent↗
PubMed1978

Mycetoma.

Explore the source record for details and available documents.

Actinomycetales↗
PubMed1978

In vitro modulation of lymphocyte responses to phytohaemagglutinin by plasma in mother and baby at the time of birth. Increased lymphocyte responses in babies of mothers with lepromatous leprosy.

Peripheral blood lymphocytes from nineteen healthy mothers, mothers with borderline tuberculoid leprosy and fourteen mothers with borderline or polar lepromatous leprosy, and their newborn babies, were stimulated in vitro with phytohaemagglutinin (PHA). The responses in medium supplemented by serum from a pool of healthy non-pregnant individuals were compared with responses in medium supplemented by plasma from the mothers or from their babies, to assay for the presence of non-specific effects on T-cell responses. It was found that plasma from the mothers at the time of labour profoundly suppressed their own lymphocyte responses to PHA. However, the lymphocyte responses of healthy mothers were not significantly suppressed when cultivated in the presence of plasma from the babies, indicating that the suppressive factor(s) of normal pregnancy did not pass the placental barrier. Plasma from mothers with leprosy had a greater inhibitory effect on their babies' lymphocytes than plasma from healthy mothers. This raises the possibility that plasma from leprosy patients contains suppressive factors other than those associated with pregnancy. Babies of lepromatous leprosy mothers, who might have been exposed to mycobacterial antigens in utero, had higher PHA responses than the other babies, possibly due to a compensatory reaction to early stresses in the immune system.

Female↗
PubMed1976

Evidence for prevention of borderline leprosy reactions by dapsone.

68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups indicates that, contrary to previous teaching, dapsone given in higher dosage does not predispose patients to reversal reactions and indeed may prevent them.

Adolescent↗