Astemizole--induced paresthesiae.
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Biomedical subjects
Publications and source records attributed to R S Bedi.
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Clinico-radiological profile of 100 geriatric pulmonary tuberculosis cases hailing from hilly areas of Himachal Pradesh was studied. The clinical presentation was altered due to associated smoking as well as chronic obstructive pulmonary disease. Breathlessness was the main presenting feature. Sixty-five cases had exudative lesions radiologically. Both conventional and short course regimens were equally effective. Drug toxicity was not a major problem. Delayed action taken and poor compliance were main handicaps in such cases. Need for individualized care for geriatric patients is stressed.
Sixty-six permanent residents of Punjab, presenting with chest complaints and absolute eosinophil counts (AEC) over 2000 per cumm were investigated to find out the cause of high eosinophilia. Tropical pulmonary eosinophilia (TE) was responsible for high eosinophilia in 27 cases (40.9%), even in this region where filariasis is not endemic. Severe asthma (23 cases), allergic bronchopulmonary aspergillosis (ABPA-5 cases), drug reaction (2 cases) and chronic eosinophilic pneumonia (2 cases) in adults and ascariasis (6 cases) in children were other main causes of high eosinophilia. It is emphasized that all cases with high blood eosinophilia should not be labelled as cases of TE simply on the basis of AEC over 2000 per cumm. This is all the more important for non-filarial regions. Only a systematically conducted work up can clinch the correct diagnosis in such cases.
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A case of metronidazole-induced asthma is being described. To the best of my knowledge, bronchospasm due to this drug has not been reported in medical literature so far.
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Immunoglobulins (IgG, IgA & IgM) levels were estimated in 50 bacillary cases of geriatric pulmonary tuberculosis (PTB) and 25 healthy controls of comparable age group by single radial immunodiffusion technique. All Igs were raised in PTB cases, the rise being directly proportional to the radiological extent of disease. Exudative cases had more marked rise compared to patients with productive and fibrotic lesions. Those cases of PTB having associated COPD (28 cases), showed less marked increase in Igs and with treatment, Ig levels declined, the decline was slower in cases having associated COPD.
Salient clinico-radiological features of 27 cases of tropical pulmonary eosinophilia (TPE), encountered amongst permanent residents of Punjab, who had never gone out of this State, are reported. This should dispel the commonly held view that TPE is rare in this part of the country.
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