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Biomedical subjects

R S Dillon

Publications and source records attributed to R S Dillon.

7 recordsLinked to original sources
PubMed1991

Role of cholinergic nervous system in healing neuropathic lesions: preliminary studies and prospective, double-blinded, placebo-controlled studies.

The amplitudes of photo-electric-plethysmography (PPG) tracings were significantly increased by subcutaneous injections of methacholine (MC) and diminished by injections of atropine (AT) as compared with placebo injections of multi-electrolyte solution (MES) both in 8 normal subjects and 11 patients with diabetic peripheral neuropathy. AT-containing lotion delayed healing compared with placebo in the forearms of 6 normal subjects. MC-containing lotion sped healing compared with placebo in the forearms of 6 subjects with diabetic neuropathy. Thigh incisions in 6 neuropathic patients were shown to heal faster if soaked in MES rather than saline. Healing with the MES solution was shown to be further increased by the addition of MC to the solution and to be decreased by the addition of AT. The addition of MC produced erythema and an increase in the amplitude of PPG tracings. AT solutions produced blanching and a decrease in the PPG amplitude. It was concluded that (1) the slow healing characteristic of neuropathic ulcers is associated with a loss of cholinergic nerve function; (2) cholinergic stimulation will increase capillary blood flow and promote healing while cholinergic blockade has opposite effects; (3) secondary ischemia makes the ulcers susceptible to the deleterious effects of therapeutic agents such as saline; (4) the ischemic tissue will heal faster with a balanced MES than with saline; and (5) the benefits of MES on healing are augmented in patients with diabetic neuropathy by the addition of cholinergic agents to the solution.

Atropine↗
PubMed1986

Successful treatment of osteomyelitis and soft tissue infections in ischemic diabetic legs by local antibiotic injections and the end-diastolic pneumatic compression boot.

Thirty-four legs at risk of amputation due to peripheral arterial insufficiency associated with ischemic necrosis, soft tissue infections, osteomyelitis, and variable degrees of peripheral neuropathy were reported in 28 diabetic patients. Amputation had been considered in 27 legs for which standard therapies had failed for the current illness and in two legs in which standard therapy had failed for previous illnesses. Local therapy was the initial form of therapy for five legs in which standard therapy appeared likely to fail. Infection was controlled in all patients with the use of local antibiotics and compression boot therapy. Early leg amputation was avoided in all but one patient. Late leg amputation occurred in two patients who were lost to follow-up care. Osteomyelitis, ischemic necrosis, and advanced soft tissue infection were shown not to be clear-cut indications for amputation in the ischemic diabetic foot.

Aged↗
PubMed1986

Treatment of resistant venous stasis ulcers and dermatitis with the end-diastolic pneumatic compression boot.

The end-diastolic pneumatic compression boot was used to treat 17 patients with difficult or refractory stasis dermatitis and ulcers. Decreases in induration, pigmentation, and palpable thrombi were observed and all patients were improved or healed. The boot treatment allowed effective local administration of antibiotics on gauze wrappings. Removal of the latter after treatments provided a means of nonsurgical debridement. Healing was maintained by periodic outpatient boot treatments in patients with close followup. Ulcers recurred in patients lost to followup but responded again to boot treatment. One diabetic man with knee contractures and both severe venous and arterial disease relapsed repetitively and lost both legs in spite of bilateral femoral-popliteal bypasses and his boot treatments.

Adult↗
PubMed1984

Saving on soaks.

Explore the source record for details and available documents.

Bacterial Infections↗
PubMed1980

Effect of therapy with the pneumatic end-diastolic leg compression boot on peripheral vascular tests and on the clinical course of peripheral vascular disease.

The Circulator Boot is a new end-diastolic pneumatic leg compression device. This report describes its effect on 6 normal young people, 8 ambulatory patients with mild peripheral arterial disease, and 21 consecutive patients (of whom 18 were hospitalized) with severe peripheral arterial disease in 25 legs. The courses of 4 patients are discussed in detail. Significant beneficial effects were documented by subcutaneous PO2 levels, pulse volume measurements, ankle blood pressure measurements, and Doppler ultrasound tracings. Twenty-two of the 25 severe legs benefitted clinically from therapy. Immediate therapeutic effects from the boot are attributed to decreases in venous pressure, interstitial fluid pressure, vasoconstriction, and viscosity, and to increases in cardiac output, pulse pressure, and fibrinolysis in the treated leg. The long-term beneficial effects of boot therapy may be related to improved collateral flow and to the rechanneling of obstructed vessels.

Aged↗
PubMedDate not supplied

Improved serum insulin profiles in diabetic individuals who massaged their insulin injection sites.

Eight insulin-dependent diabetic patients were studied on two consecutive mornings when they injected their usual morning mixtures of insulin. One morning they massaged their insulin injection sites 15 min after the injection. Free insulin levels rose 10.14 +/- 9.91 microU/ml higher (P less than 0.05) and serum glucose levels fell 8.3% lower (P less than 0.05) 30 min after massage than on the control study day.

Absorption↗