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Biomedical subjects

R S Hattner

Publications and source records attributed to R S Hattner.

At least 73 records · Page 4Linked to original sources
PubMed1980

Loosening of the total knee arthroplasty: detection by radionuclide bone scanning.

Pain after total knee arthroplasty is a common clinical problem in orthopedics, and prosthetic loosening, often requiring surgical revision, is usually the etiology. Since standard clinical and radiographic diagnostic measures have not proven totally satisfactory, a study of the utility of bone scintigraphy to assess stability of the knee prosthesis was done. Thirty-five patients with 39 prostheses were studied. Seventeen patients with 21 total knee arthroplasties served as controls and were asymptomatic, were stable at surgery, or improved with conservative management. Eighteen knees in 18 symptomatic patients composed the experimental group. Of these, 11 knees were loose at surgery and seven have had surgery recommended. Scintigrams of the knees were obtained using 99mTc-MDP, and ranked 0-3 corresponding to increasingly abnormal localization by three observers. Highly significant differences were observed between the abnormal and control groups (p less than 0.001). Reciprocal changes in sensitivity and specificity with increasingly stringent criteria were shown. While it is apparent that the bone scan cannot be used as the sole diagnostic method for evaluation of prosthetic stability, it does seem to be useful adjunct along with clinical criteria and radiographic studies.

Evaluation Studies as Topic↗
PubMed1979

Scintigraphic features of nonosteogenic fibroma.

Three cases of nonosteogenic fibroma or fibrous cortical defect are presented which demonstrated scintigraphic findings of minimal to mild increased uptake of bone-seeking radiopharmaceutical and thus helped to distinguish these lesions from other benign or malignant abnormalities. The authors suggest that the two types of lesion are not fundamentally different from one another.

Adolescent↗
PubMed1978

Computed tomography in detecting calvarial metastases: a comparison with skull radiography and radionuclide scanning.

A clinical study comparing the relative sensitivities of computed tomography, skull radiography, and radionuclide scanning in the detection of skull metastases indicated that CT was the least sensitive of these three modalities. CT could however detect a majority of lesions if scans were viewed at appropriate window settings. Phantom studies showed that the limitations of CT can be related to limited spatial resolution, the density of the lesions, partial volume averaging, and plane of section.

Humans↗
PubMed1978

Ratio of late to early radionuclide uptake: a method for distinguishing osteoporosis from osteomalacia in animal models.

The ration of late to early uptake of several radionuclides was examined as a method for distinguishing states of abnormal bone metabolism. Nutritional osteoporosis (secondary hyperparathyroidism) and osteomalacia were produced in young rats and compared to a control group. The ratio of early (3-6 hrs.) to late (4-6 days) uptake of barium-131, nitrate, indium-111 EDTMP, and lead-203 were studied, as was that of strontium-85 chloride, a calcium analogue. Ratios of late to early uptake were found to distinguish osteomalacia from osteoporosis in the models when strontium-85 or barium-131 were used. Barium-131 may be a clinically useful alternative to strontium-85 in the evaluation of metabolic bone disease due to its shorter half-life and lower radiation dose.

Animals↗
PubMed1977

Segmental acute tubular necrosis in kidneys with multiple renal arteries transplanted from living related donors.

Ten patients received kidneys from living, related donors, the transplants having multiple renal arteries; a retrospective analysis of the postoperative Hippuran renograms is presented. All seven kidneys that had the large artery reopened before anastomosis of the smaller, developed scintigram findings suggestive of acute tubular necrosis (ATN) in the region with the more prolonged ischemia. Three similar kidneys with simultaneous recanalization of both renal arteries had normal Hippuran scintiphotos. Electron photomicrographs from upper- and lower-pole biopsies--in one case undergoing sequential revascularization--confirm the development of ischemic changes consistent with ATN in the half of the kidney developing scan findings of ATN.

Acute Kidney Injury↗
PubMed1977

Differentiation of reversible ischemia from end-stage renal failure in nephrotic children with 131I-hippurate dynamic scintigraphy.

In renal failure associated with the nephrotic syndrome, therapeutic strategy is highly dependent upon the cause of the renal failure. Dynamic hippurate scintigraphy was studied in five pediatric patients. Four had nephrotic syndrome, and of these, three had acute renal failure. The fifth patient had end-stage renal failure. Specific alteration in renal hippurate kinetics offers a noninvasive assessment of renal failure in this clinical setting.

Acute Kidney Injury↗
PubMed1976

Brain scintigraphy in recurrent medulloblastoma.

Twenty-three patients with previously treated medulloblastoma had brain scintigrams revealed posterior fossa recurrence in 15 patients and supratentorial metastases in 9; only 1 of the latter was clinically suspected. Two subdural hematomas and one calvarial metastasis were also detected. Comparison with other diagnostic evidence shows agreement in 13 out of 14 cases (93%) for posterior fossa recurrence and 8/10 (80%) for supratentiorial masses. Brain scintigraphy appears to be a sensitive and specific test for the detection of recurrence and metastasis in patients with treated medulloblastoma.

Adolescent↗
PubMed1975

Bifurcation of the portal vein appearing as a focal defect on the liver image.

A focal defect was seen on a gamma camera image of the liver in 2 patients, a 52-year-old woman with abdominal pain and a 46-year-old woman with pancytopenia. Liver function was normal, and no tumor stain was seen. Angiography revealed that the "defect" was in reality the bifurcation of the portal vein. These findings re-emphasize the importance of visceral angiography as a complement to radionuclide imaging in the study of liver disease.

Angiography↗
PubMed1975

Posterior fossa scintiangiography: documentation of genetic penetrance of von Hippel-Lindau syndrome in a clinically unaffected girl and her father.

The 16-year-old clinically normal daughter of a patient with the von Hippel-Lindau syndrome demonstrated a vascular posterior fossa lesion on scintiangiography that failed detection in delayed images. Contrast arteriography corroborated the presence of a hemangioblastoma. Noninvasive demonstration of the genetic penetrance of this disorder offers its victims an opportunity for low morbidity early surgical cure of the associated brain lesions.

Adolescent↗
PubMed1975

Significance of renewal asymmetry in bone scans: experience in 795 cases.

A retrospective study of 795 consecutive bone scans employing either 18F or 99mTc-pyrophosphate to evaluate the diagnostic value of renal asymmetry in such scans has been carried out. It is concluded that asymmetric renal images in bone scans convey relatively specific information regarding renal pathology, especially in the 99mTc-pyrophosphate studies.

Adenocarcinoma↗