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Biomedical subjects

R S Kalucy

Publications and source records attributed to R S Kalucy.

At least 19 recordsLinked to original sources

Decision making in clinically depressed patients. A transcultural social psychological study.

One of the most important cognitive deficits in depression is said to be the patient's inability to make decisions. A research design involving a cross-cultural comparison between Australian and Japanese normal controls (N = 309 and N = 743, respectively) and clinically depressed patients (N = 59 and N = 45, respectively) was used to examine the influence of culture on illness and decision-making behavior, and whether deficits in decision making may be related to culture. It was found that depression had a greater effect on decision making in Australian patients than in Japanese patients. While many differences were found between Australian and Japanese nondepressed students, few differences were found between Australian and Japanese depressed patients. Thus, there appears to be an important interactional effect of culture and depression on decision making. The theoretical and clinical implications of the results are discussed.

Adolescent

Problems of subject inclusion in psychiatric research: observations from research with psychiatric inpatients.

In a recent study of psychiatric disturbance and decision making behaviour, it was observed that a significant number of psychiatric inpatients experienced difficulties in addressing themselves to the experimental tasks at hand. Despite the large number of studies that have used psychiatric inpatients as subjects, little, if any mention has been made of these difficulties. The following report describes the difficulties that have been observed in the above research project, and examines their possible implications for clinical assessment, research, and for clinical investigations and evaluation of treatment regimes (e.g. effectiveness of particular drug therapies), which use psychiatric inpatient populations as subject sources.

Adolescent

Early morning migraine. Nocturnal plasma levels of catecholamines, tryptophan, glucose, and free fatty acids and sleep encephalographs.

Nocturnal plasma catecholamine, tryptophan, glucose, and free fatty acid levels have been measured in 19 subjects who regularly awoke from sleep with migraine. All-night polygraphic sleep recordings were also made. 13 subjects were studied on a second occasion allowing within-subject control as well as group comparison. Plasma total catecholamine and specifically plasma-noradrenaline levels were significantly higher in the three hours before the subjects awoke with migraine. No differences were found in plasma tryptophan, glucose, insulin, and free fatty acid levels in the migraine/no-migraine categories. Waking with migraine occurred significantly more often from rapid-eye movement (REM) sleep. There were no other differences in sleep pattern in the migraine/no-migraine categories.

Adult

Weight gain, thermic effect of glucose and resting metabolic rate during recovery from anorexia nervosa.

Rate of weight gain, together with metabolic rate before and after a glucose meal, were studied in a group of 15 female anorexia nervosa patients as their weight was being restored to normal levels. The previously obese anoretic patients gained weight more rapidly, on the same food intake, than those who were of normal weight before their illness began. The increase in metabolic rate (as treatment progressed) was less in the previously obese patients, who also showed a tendency for the metabolic rate to increase less after a glucose meal than the patients with no history of obesity. The thermic effect of glucose was greater in patients with anorexia nervosa than in a comparable control group of six female students.

Adult

Explanations for weight loss after ileojejunal bypass in gross obesity.

Twenty grossly obese patients underwent ileojejunal bypass operations. Measurements of calories lost in faeces showed that the malabsorption could not account for the weight loss. Furthermore, the malabsorption was not decreased two years after bypass, when weight was no longer being lost. Dietary restriction is therefore largely responsible for the weight loss and increased food intake for weight maintenance.

Body Weight

How common is anorexia nervosa? A prevalence study.

During 1972-74 nine populations of schoolgirls were surveyed in respect of the occurrence of anorexia nervosa. As well as the current school year, previous years (going back variously 3-6 years) were also carefully studied within seven of the schools. Anorexia nervosa was only identified as present or having been present if the diagnosis was unequivocal: for instance, seemingly evident and severe cases which could not be traced were excluded. The condition in severe form was found to be relatively common in the independent sector of education, probably implying a social class factor. In all such schools, the prevalence was one severe case in approximately every 200 girls. In those aged 16 and over it amounted to one severe case in about every 100 girls. Overall, these schools encountered one 'new' severe case in every 250 pupils aged 16 years and over. The condition is likely to be even more common than this study allows because of the stringent limits set here on inclusion of cases and the age-bands studied. It is concluded that severe anorexia nervosa is a common condition and is probably getting more common.

Adolescent

Weight gain and the sleeping electroencephalogram: study of 10 patients with anorexia nervosa.

The relation between reduced nutritional intake, with consequent weight loss, and sleep disturbance was studied by comparing certain sleep encephalogram patterns in a group of inpatients with anorexia nervosa before, during, and after a regimen of refeeding with a normal diet to a matched population mean weight. At low body weights patients had less sleep and more restlessness, especially in the last four hours of the night. During refeeding and weight gain slow-wave sleep initially increased and then tended to decrease during the final stage of restoration of weight back to matched population mean levels. With the overall weight gain, however, there was a significant increase in length of sleep and rapid eye movement sleep, the latter increasing especially during the later stages of weight gain. These results reaffirm that insomnia, and especially early morning waking, is associated with low body weight in anorexia nervosa, and their implications are discussed with particular reference to a hypothetical association between various anabolic profiles and the need for differing components of sleep.

Adolescent