Tabulation of somatic cell hybrids formed between lines of cultured cells.
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Biomedical subjects
Publications and source records attributed to R S Krooth.
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Mature, circulating mammalian erythrocytes lack dihydroorotic acid dehydrogenase activity. However, we have detected activity, which appears to reside in an enzyme, in malaria parasites purified from mammalian blood.
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A gene affecting the final two enzymes of uridylic acid biosynthesis does not affect a third, metabolically adjacent enzyme. Similarly, compounds that increase cellular activity for the affected enzymes do not increase activity for the third enzyme. The pyrimidine pathway can be subdivided into groups of concurrently responding enzymes. These groups may be smaller in human cells than they are in microbial cells.
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