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Biomedical subjects

R S Muther

Publications and source records attributed to R S Muther.

32 records · Page 2Linked to original sources
PubMed1980

Efficacy of minoxidil in the treatment of severe hypertension in systemic disorders.

Minoxidil, an orally effective vasodilator, was successful in lowering blood pressure in 10 patients with systemic diseases complicated by hypertension refractory to medical management. Follow-up was for periods up to 58 months. In patients not requiring dialysis prior to therapy, renal function was preserved, and in patients on dialysis, bilateral nephrectomy was avoided. Although sodium retention and reflex tachycardia were common, they were managed by beta-adrenergic blockade with propranolol and diuresis with furosemide. Results did not differ qualitatively or quantitatively from those achieved in 31 refractory hypertensives without systemic illness. Pharmacologic studies performed on hemodialysis in a patient with polyarteritis revealed a dialysis clearance of 14C-labeled minoxidil of 48 ml/min. Venous minoxidil concentrations decreased by 32% across six single dialysis treatments. Nineteen percent of the administered dose was recovered in the feces, an increased fraction compared to normal subjects.

Adolescent↗
PubMed1980

Drug therapy in renal failure: dosing guidelines for adults. Part II: sedatives, hypnotics, and tranquilizers; cardiovascular, antihypertensive, and diuretic agents; miscellaneous agents.

Data providing guidelines for drug use in adult patients with renal insufficiency are presented in tabular form with supporting references. The data are derived from the current medical literature. If specific information about a drug is unavailable or conflicting, emphasis is given to normal pharmacokinetic variables in arriving at recommendations for therapy. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for dialysis suggested.

Adult↗
PubMed1980

Drug therapy in renal failure: dosing guidelines for adults. Part I: Antimicrobial agents, analgesics.

Data are presented in tabular form that provide guidelines for drug use in adult patients with renal insufficiency. The data are derived from the current medical literature. If specific information about a drug is unavailable or conflicting, emphasis is given to normal pharmacokinetic variables in arriving at recommendations for therapy. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for dialysis suggested.

Analgesics↗
PubMed1980

Granulomatous sarcoid nephritis: a cause of multiple renal tubular abnormalities.

We report the eleventh case of granulomatous sarcoid nephritis and review the previous literature. Although not as commonly recognized as calcium nephropath, granulomatous nephritis may be an important cause of morbidity and mortality in patients with sarcoidosis. Its characteristics are similar to other tubulo-interstitial diseases. Mild to moderate albuminuria, microscopic hematuria and sterile pyuria predominate. Hypertension is usually absent and renal size is well preserved. Urinary concentration defects (including nephrogenic diabetes insipidus), renal tubular acidosis and inappropriate glucosuria may also be seen. Interstitial inflammation with non-caseating granulomas, epithelioid and multinucleated giant cells is the usual histologic picture. Intimal thickening is not infrequent and granulomas may occasionally involve the small arteries. Immunofluorescence and electron microscopic findings are non-specific.

Adolescent↗