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R S SCHWARTZ

Publications and source records attributed to R S SCHWARTZ.

14 recordsLinked to original sources
PubMed1964

INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.

A brief course of treatment with 6-mercaptopurine prevented conversion of 19S to 7S antibodies during the immune response of rabbits to bovine gamma globulin. Specific reactive homologous 7S antibodies given intravenously to animals with such incompletely developed humoral reactions led to an abrupt fall in 19S antibodies. After a lag period the synthesis of 7S antibodies was apparently normal. These results suggest that the concentration of 7S antibodies controls the synthesis of 19S antibodies.

Antibodies↗
PubMed1963

Homologous disease reactivation by x-radiation.

Hybrid F(1) mice (BDF(1)) that failed to develop homologous disease after injection of parental (C57 Bl/6) spleen cells were treated with 400 roentgens of total body x-radiation 13 months later. Typical homologous disease promptly developed in these mice. This suggests that parental lymphoid cells may acquire immunologic tolerance to "foreign" host antigens and that the tolerant state is disrupted by sublethal doses of radiation.

Animals↗