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Biomedical subjects

R Sörensen

Publications and source records attributed to R Sörensen.

At least 19 recordsLinked to original sources
PubMed1998

[High resolution functional magnetic resonance tomography with Gd-DTPA eyedrops in diagnosis of lacrimal apparatus diseases].

UNLABELLED: Both dacryocystography and dacryoscintigraphy are well established in the evaluation of stenoses of the lacrimal drainage system. They provide limited information about the ductal anatomy itself and about periductal structures. MR imaging was evaluated for its capability to directly visualize the lacrimal drainage system in detail and simultaneously provide functional characterization of dacryostenosis. SUBJECTS AND METHODS: Twenty-seven lacrimal drainage systems of 23 patients suffering from epiphora were examined in an MR unit before and after conjunctival and intravenous application of Gd-DTPA using a surface coil. RESULTS: Dacryostenosis was found in 23 of 27 lacrimal systems. Stenoses were localized to the canalicular (n = 3), saccular (n = 8), and ductal (n = 12) level, and were classified as stenosis or occlusion. CONCLUSION: MR imaging with conjunctival contrast application allows within one examination both detailed morphological and functional assessment of the lacrimal drainage system with depiction of surrounding structures. Limitations arise mainly from demands on technical and patient-related preconditions.

Contrast Media↗
PubMed1996

Epidural lipomatosis: case report and literature review.

We report a case of symptomatic epidural lipomatosis in a 36-year-old man following a heart lung transplant and 3.5 years of steroid medication. A review of the pertinent literature emphasises the importance of including this diagnosis in the differential diagnosis of patients receiving steroid medication or markedly obese patients with back pain or symptoms suggesting spinal cord or cauda equina compression.

Adult↗
PubMed1991

[The evaluation of renal tolerance for roentgen contrast media by determination of urinary kidney-specific proteins].

In the present trial kidney-specific proteins were studied enzymatically or quantitatively in patients' urine after intravascular administration of water-soluble X-ray contrast media, in order to judge about their renal tolerance. 5 clinical trials (phase III), including 198 patients, were carried through, within several radiological examinations. The examined X-ray substance was Iosimide, a new monomeric, nonionic low osmolar c.m. It was compared to the nonionic Iopromide and Iopamidol as well as to the ionic, high osmolar sodium-meglumine-diatrizoate. Enzyme activities of alanine-aminopeptidase (AAP), gamma-glutamyltransferase (GGT), beta-n-acetylglucosaminidase (NAG), kallikrein with creatinine as point of reference were kinetically measured in 4 urine samples (1 before c.m. administration the others as 24 hours urine samples of the following 3 days). Beside the quantitative determination of protein and albumin an electrophoresis was started, when diagnosis was obvious. Kallikrein was brought to the diagnostic palette of this study in order to include the distal segment of the nephron. The specific protein excretion patterns of nonionic c.m. in urine are not different from each other. In contradiction to this, the results of the low osmolar nonionic Iosimide compared to the high osmolar diatrizoate, show evident differences for the benefit of Iosimide.

Acetylglucosaminidase↗
PubMed1990

[Imaging procedures in diagnosis of variceal hemorrhage].

Imaging procedures in patients suffering from portal hypertension and the problems arising from this condition are limited to the demonstration of the morphology of the collateral circulation towards the superior and the inferior vena cava. Imaging is essential prior to elective and emergency treatment of bleeding varices. Non-invasive and invasive imaging procedures are available. Acute hemorrhage of varices usually can not be demonstrated with any of the methods. Important is the preoperative evaluation of the portal system and the angiographic demonstration of the anatomy.

Diagnostic Imaging↗
PubMed1988

[Tele-thermography in the diagnosis of deep leg and pelvic venous thrombosis].

The results of thermography were compared with those of phlebography in 235 patients with suspected deep venous thrombosis in the legs. Any thermal difference between the two sides was regarded as abnormal. On this basis, thermography had a sensitivity of 97%. Thermography is therefore a reliable, simple, non-invasive and repeatable examination for the exclusion of leg vein thrombosis.

Adult↗
PubMed1988

Günther vena caval filter: results of long-term follow-up.

A Günther vena caval filter was implanted in the inferior vena cava in 59 patients to prevent pulmonary embolism. This newly available device, which can be inserted percutaneously via a 10-French introduction system, has three filtering planes. No complications occurred at the puncture site. Follow-up included clinical examinations (54 patients), plain radiographs (50 patients), and CT scans (41 patients); these examinations were performed up to 21 months after implantation. Caudal migration of the filter occurred in 35 (70%) of the 50 patients who had radiographs, but no cranial or oblique movement occurred. Occlusion of the filter was noted in three (7%) of 41 patients who had CT examinations. Thromboemboli were seen inside the filter in 16 (39%) of the 41 patients who had CT scans. Recurrent pulmonary embolism was not observed after filter implantation. The Günther vena caval filter seems to be a satisfactory device for preventing pulmonary embolism.

Adult↗
PubMed1987

Aneurysm of the right ovarian vein--an unusual cause of pulmonary embolism.

This case reports a 23-year-old female who experienced a massive bilateral pulmonary embolism. The source of thrombi was found to be in a large saccular aneurysm of the right ovarian vein. The pulmonary emboli were treated by local infusion of streptokinase. The patient was cured after removal of the aneurysm by surgery.

Aneurysm↗
PubMed1987

Varicoceles: distal occlusion with coaxial catheter system.

A coaxial balloon catheter system with an inner catheter and a steerable wire for selective catheterization and occlusive therapy is described. The system was designed primarily for distal sclerotherapy of varicoceles but can also be used in other arterial or venous systems.

Catheterization↗
PubMed1987

Percutaneous transluminal treatment of varicoceles: where to occlude the internal spermatic vein.

Percutaneous transluminal sclerotherapy is an accepted treatment for varicoceles. It is administered by applying a liquid sclerosing agent to the internal spermatic vein. However, the optimal site for the placement of the occlusive material has not been evaluated previously. Therefore, the success rate of sclerotherapy was determined in two groups of patients. In the first group (34 patients), the liquid agent was applied in the cranial part of the internal spermatic vein; in the second group (113 patients), the agent was applied in the caudal part of the vessel at the level of the inguinal ring. The success rate determined 3 months after therapy by telethermography was significantly higher after treatment in the caudal part (82%) than in the cranial part (68%) of the vessel. Sclerotherapy at the level of the inguinal ring appears to be superior to therapy in the cranial part of the internal spermatic vein.

Adolescent↗
PubMed1986

Technical difficulties of selective venous blood sampling in the differential diagnosis of female hyperandrogenism.

To determine glandular steroid release of adrenals and ovaries in female hyperandrogenism, a standardized method for percutaneous transfemoral venous blood sampling was developed. In eight volunteers and 67 patients, catheterization was performed during the early follicular phase (days 3-7; between 8 and 10 a.m.) to reduce interference from cyclic and circadian variations of secretion. Serial samplings reduced the episodic effluent changes. Anatomical variations and collateral flow as well as stress effects and the dosage of contrast media were studied. During catheterization, peripheral cortisol levels did not differ significantly from control groups. Collaterals had no effect on hormone levels. Contrast media increased cortisol effluent levels only when they were sampled following venography. Four-vessel venous sampling was found to be indicated if peripheral testosterone was more than 1.5 ng/ml and/or dehydroepiandrosterone sulfate more than 6,700 ng/ml. If an ovarian (adrenal)/peripheral gradient of testosterone exceeded 2.7 ng/ml, surgical intervention for tumor removal at the site of hormone excess was felt to be necessary.

Adolescent↗
PubMed1986

[Hyperthecosis ovarii--a tumor-like change in androgenized females].

Hyperthecosis has been repeatedly described as a disease entity separate from polycystic ovaries (PCO) as characterised by stromal luteinisation, obligatory virilism and purely ovarian androgen hypersecretion. This study compares the findings in patients with hyperthecosis (n = 10), PCO (n = 33) and androgen-secreting ovarian tumours (n = 7). It included selective ovarian-adrenal vein catheterisation with measurement of testosterone (T), dihydro-T, androstenedione, DHEA and its sulfate, 17 alpha-hydroxyprogesterone and cortisol before and after dexamethasone; determination of free T, oestrone, oestradiol and prolactin as well as LH and FSH before and after GnRH. In histologically proven hyperthecosis, signs of virilism were absent in 6 cases. A specific hormone profile could not be identified. Mixed ovarian-adrenal androgen hypersecretion was documented in 4 patients (purely ovarian: n = 6). Ovarian T output frequently fell within the tumour range (n = 4). It is concluded that the minor differences between hyperthecosis and PCO represent only variable manifestations of the same heterogeneous disturbance of androgen metabolism. However, it is of special clinical relevance to rule out a tumour in patients with hyperthecosis.

Adult↗
PubMed1986

[Non-invasive imaging procedures in the diagnosis and control of therapy of varicoceles. 2. Importance of thermography and sonography for therapy control following sclerotherapy of varicoceles].

In 41 patients with varicoceles, a combined thermographic and sonographic examination of the scrotum was carried out pretherapeutically as well as 14 days and 3 months after percutaneous sclerotherapy. In the differentiation of a successful sclerosing or a varicocele persistence, thermography shows a higher sensitivity than sonography with 34 posttherapeutic normal findings and 7 persisting hyperthermias. The sonographic sign of a successful varicosclerosation is the absence of venous dilation of the pampiniform plexus in an upright position with Valsalva's manoeuvre in 36 patients. After proximal sclerosing of the testicular vein sonography reveals a reduction in vascular size; thrombosed veins of the pampiniform plexus are demonstrated only after distal sclerosing. There are no sonographically detectable disorders of the testes after varicosclerosation. Thermographic and sonographic control after percutaneous sclerotherapy or surgical ligation of varicoceles is indicated in children and in doubtful clinical or spermatological cases.

Adolescent↗
PubMed1986

Varicoceles: combined sonography and thermography in diagnosis and posttherapeutic evaluation.

One hundred eighteen patients with clinically suspected varicocele were examined with thermography and sonography before phlebography of the internal spermatic vein (ISV). The combination of sonography and thermography led to an exact differentiation among eight patients with normal findings (6.8%), 103 with left-sided varicoceles (87.3%), six with bilateral varicoceles (5.1%), and one with a right-sided varicocele (0.85%). The accuracy of thermography was 98.4% and of sonography, 92.7%. With sonography, venous dilatation was detected when the patients were upright and the Valsalva maneuver was being performed. Thermography was more sensitive than sonography in detecting persistent varicocele in 63 patients reexamined after sclerotherapy. Sclerotherapy within the inguinal segment of the ISV gave better results (82.9%) than that within the proximal segment (77.3%).

Adolescent↗
PubMed1985

[Polycystic ovaries: specific disease picture or nonspecific symptom?].

This study compares the clinical, biochemical and laparoscopic findings in androgenized patients with (n = 33) and without (n = 17) polycystic ovaries (PCO). It included selective ovarian-adrenal vein catheterisation with measurement of testosterone, dihydrotestosterone, delta 4-androstendione, dehydroepiandrosterone and its sulfate, 17 alpha-hydroxyprogesterone and cortisol in peripheral and glandular venous samples; determination of free testosterone, oestradiol, oestron, LH, FSH and prolactin in peripheral blood; GnRH and TRH double stimulation, as well as dexamethasone suppression tests. There was no correlation between the morphological, clinical, and endocrine changes. A PCO-specific hormonal pattern was not identifiable. Based on catheterisation data, combined ovarian-adrenal androgen hypersecretion was found in 46% of PCO cases; purely ovarian (21%) or adrenal (12%) overproduction were not as frequent. The dynamic function tests proved to be non-specific; e.g., dexamethasone suppressed not only adrenal, but also ovarian androgen output. It is concluded from these data that PCO are not a nosologic entity, but rather a non-obligatory sign of hyperandrogenism. Laparoscopy is, therefore, without clinical relevance in these patients with non-neoplastic hyperandrogenaemia.

Adult↗