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Biomedical subjects

R Sörnäs

Publications and source records attributed to R Sörnäs.

13 recordsLinked to original sources

Peripheral motor neuropathy caused by excessive intake of dapsone (Avlosulfon).

A case of selective peripheral motor polyneuropathy caused by excessive intake of dapsone is described. The condition was characterized by a peripheral muscle weakness in all limbs, normal sensitivity and present, although weak, muscle reflexes. Neurophysiologically, low amplitude muscle responses, prolonged distal latencies and reduced motor conduction velocities were found together with electromyographic signs of denervation. Sensory neurography was normal. The patient showed a complete clinical recovery and a marked neurophysiological restitution after termination of the excessive drug intake. The patient was found to acetylate dapsone at a slow rate. The case is compared with those previously reported in the literature.

Adult↗

Clinical and cerebrospinal fluid findings in lymphocytic meningo-radiculitis (Bannwarth's syndrome).

11 patients with lymphocytic meningo-radiculitis (Bannwarth's syndrome) are described. The disease is characterized by intensive pain, often radiating and migrating, and neurological deficits, i.e. peripheral facial palsies, as well as disseminated radiculopathies. In 4 patients the onset was preceded by an arthropod bite, close to which 3 patients exhibited an erythema chronicum migrans. In the cerebrospinal fluid there was a mononuclear pleocytosis, predominantely by lymphocytes. In the early stages, a plasma cell reaction was frequently encountered. Protein analysis indicated a defect in the blood brain barrier and an intrathecal synthesis of IgG. All patients recovered almost completely from their neurological symptoms within 1-2 months, irrespective of treatment.

Adult↗