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Biomedical subjects

R Süss

Publications and source records attributed to R Süss.

At least 37 records · Page 2Linked to original sources
PubMed1987

Natural cytotoxic cells from rat liver and spleen kill human glioma cells.

Natural cytotoxic cells from rat spleen and rat liver, (isolated using the collagenase method) were found to be cytotoxic against different lines of human gliomas: T406, T508, T705, HeRo, HeRoCl 1, HeRoCl 8, and HeRo-SV 7/114. After 18 h the lytic units ranged from 75 to 251 in the liver and from 5 to 24 in the spleen. Analyzing the ratio of lysis at 4 h/18 h, it may be concluded that this natural killing is predominantly macrophage (Kupffer cell)-dependent. Lysis by Kupffer cells cannot be increased by transforming glioma cells with SV40. Experiments with SV40-transformed mouse fibroblasts (3T3) and virus-transformed human cell lines (SV80) suggested a "SV40" receptor on Kupffer cells. Thus Kupffer cells have receptors for glioma cells and SV40-dependent membrane structures.

Animals↗
PubMed1986

Liver as a tumor cell killing organ: Kupffer cells and natural killers.

Sinusoidal rat liver cells spontaneously kill tumor cells in vitro. They have the same preferences as do spleen cells for certain types of tumor cells, YAC-1, P815, BSP73Asml, BSP73As, EB, EsB, and L5222. Metastasizing tumor cells are less sensitive than their nonmetastasizing counterparts. Not all effector cells are Kupffer cells. These nonmacrophage killer cells share some features with classical natural killers: (a) fast reactions (4 h); (b) high toxicity against YAC-1 cells; (c) sensitivity to anti-asialo GM1 globulin; (d) similar age dependency; (e) short biological halflife (approximately 1 day) (deduced from radiation experiments); (b) silica particle insensitivity; and (g) nonadherence. The natural killing potency of the liver is higher than that of the spleen. The reduction of tumoricidal capacity of the liver in germ-free animals suggests environmental influences. Tumoricidal capacity (organ capacity) is increased in rats chronically fed thioacetamide, carbon tetrachloride (CC14), dimethylaminoazobenzene, and N-nitrosomorpholin.

Adaptation, Physiological↗
PubMed1985

New ways in counselling on prenatally diagnosed congenital malformations. An experimental information project using Bildschirmtext/Videotex.

A bibliometric analysis of source items recently published in German-language gynaecology journals and one German-language journal covering a broader field of medicine yielded but one publication linked with prenatally diagnosed congenital malformations and their surgical treatment. Thus, journals usually assessed by the gynaecologist are in this respect at present not a useful source of information for the practitioner outside specialised centres. In order to explore the usefulness of Bildschirmtext (BTX, Videotex), a new electronic medium, as an alternative in counselling for congenital malformations and similar rare medical problems, an experimental database was constructed. Pages giving data on diagnostic pathways, incidence, prognosis, specialised treatment centres and suggested further reading on abdominal wall defects were compiled and are stored in a central computer of the German Federal Postal Services. Data are accessible via the regular telephone network and a specially equipped TV set. The method, although still experimental, is considered useful for offering medical intelligence to the medical professional outside specialised centres.

Abdominal Muscles↗
PubMed1984

Tumor cells adhere to intraperitoneal injection sites.

Tumor cells injected intraperitoneally form cell plaques at injection sites in the abdominal wall of mice within a few minutes. Tumor cells appear to be transported passively and chemotactic factors are not involved. Dihydrocortisol blocks cell adherence and silica particles , assumed to destroy macrophages, abolish cell plaque formation.

Animals↗
PubMed1984

Liver as a tumor-cell-killing organ.

Lymphoma cells (Eb and ESb, the metastasizing variant) were injected via a mesenteric vein. 85% to 95% of these cells were trapped in the liver. Most of the Eb cells (81%) were destroyed within 18 hours, ESb cells prove to be more resistant: only 28% of these cells were destroyed within this time. 51-Chromium release assay (4 hours) revealed a similar sensitivity of these two tumor cell strains.

Animals↗
PubMed1983

Studies on intravascular phagocytosis in the lung.

In this paper we have shown for the first time endocytosis by intravascular lung phagocytes. Glutaraldehyde-treated erythrocytes (discocytes) homed rapidly to the rat lung as measured by scintigraphic procedures. Transmission and scanning electron microscopy showed that the discocytes are phagocytosed by macrophages, blood monocytes and granulocytes as whole cells. This process could not be inhibited by silica treatment.

Animals↗
PubMed1982

Kupffer cells recognize trinitrobenzene-labeled erythrocytes.

Chemical-modified erythrocytes (trinitrobenzene-modified erythrocytes (TNB-RBC)) are trapped in vivo rapidly by liver macrophages (Kupffer cells). The liver homing of TNB-RBC is dependent on the concentration of TNB-residues coupled to the surface of RBC. High concentrations induce liver homing, low concentrations spleen homing.

Animals↗
PubMed1981

Lectin mediates homing of sialidase-treated erythrocytes of the liver as revealed by scintigraphy.

Mammalian erythrocytes loose their normal circulatory pattern following desialylation by sialidase and are trapped in the liver. The mechanism responsible for this phenomenon has been studied by a new scintigraphic method. We report here that the retention of asialo-erythrocytes in the liver is due to the interaction between a lectin-like receptor on Kupffer cells and terminal D-galactosyl residues exposed on erythrocytes after sialidase treatment. The major findings supporting the conclusion are: First, kinetics of asialo-erythrocyte accumulation in the liver are identical in conventional and germfree animals, demonstrating that the presence of serum antibody is not essential. Second, trapping of asialo-erythrocytes can be substantially inhibited by intravenous injection of N-acetyl-D-galactosamine or galactosylated bovine serum albumin, other saccharides or glycoproteins are less or not at all effective. This specificity pattern is characteristic for the D-galactose-specific lectin on Kupffer cells. It therefore appears that the retention of sialidase-treated erythrocytes in the liver is lectin- and not antibody mediated.

Animals↗