Biomedical subjects
Publications and source records attributed to R Sadove.
Exposure to hydrofluoric acid is serious and many times fatal. We have reported the case of a man who was totally immersed in a 10% hydrofluoric acid solution. A multidisciplinary approach to management was important to his ultimate recovery.
In an effort to prove the etiology of the cleft lip nasal deformity, 23 patients with unilateral cleft lip underwent biopsy through the midportion of the columella from mucosa to mucosa. This tissue "sandwich" contained an internal control of cleft and noncleft medial crus cartilage. With the use of special stains and examination under the microscope at low, medium, and high powers, sections were evaluated on the basis of presence of abnormal chondrocytes, number of binucleate chondrocytes, number of nucleated chondrocytes, number of lacunae, perichondrial thickness, and cartilage thickness. In each specimen examined, there were no significant differences between cleft and noncleft sides, proving histologically the previous subjective observation that the deformity is extrinsic, due to distortion of the lower lateral cartilage by abnormal vectors of force.
The patient described in this article presented with chronic open infected medial and lateral malleolar wounds resulting from a compound tripod fracture of the right tibia and fibula. Primary wound coverage was achieved through the application of a split free rectus abdominis muscle transfer. This represents an exciting new application of an already versatile and popular free muscle transfer.
The effect of hematoma formation on thrombus formation at microvascular anastomotic sites in the femoral arteries and veins of rats was investigated. No difference in anastomotic patency or thrombus formation was observed in the presence of perivascular hematoma, although compression secondary to hematoma formation was not an experimental variable. This study suggests the possibility that the velocity of blood flow (which increases with vasoconstriction) counteracts the thrombogenicity of changes in the flow volume (which decreases with vasoconstriction) by preventing the accumulation of thrombogenic materials. The authors suggest that the role of vasoconstriction in relation to thrombus formation and anastomotic patency should be explored further using topical vasoconstrictors and appropriate platelet fractions.