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Biomedical subjects

R Sadun

Publications and source records attributed to R Sadun.

11 recordsLinked to original sources
PubMed1995

[Osteoporosis and densitometry screening: preliminary results].

We have examined the bone densitometry with osteoradiometer (ORM) of 355 patients who came to the "Centre for Prevention, Diagnosis and Therapy of Osteoporosis" at the Israelitic Hospital of Rome. 144 patients, 141 females and 3 males, will be studied in the future because their densitometric values are lower than the values considered normal for age and sex. We have valued anamnestic data (age, menopause, pregnancies, excessive use of alcohol and smoke, sedentary habits), medical data hyperthyroidism, OCB, chronic diarrhoea) and surgical data (ovariectomy, thyroidectomy, gastro-duodenal resection, mastectomy) to have the correct outline of the patient situation before further researches and beginning the best medical therapy. For the prevention and screening of people "at risk" densitometry is irreplaceable both pre-clinical osteopeny, and for checking the effects of the therapy.

Adult↗
PubMed1984

Femoral metastases from carcinoma of the breast. Pathological and clinical aspects.

In long bone metastases from breast carcinoma, the femur is the bone most frequently involved. Osteolysis is brought about by the osteoclasts, by the neoplastic cells themselves, and to some extent by autolysis of the osseous tissue adjacent to the metastasis. When the metastases are asymptomatic, radiotherapy and antiblastic chemotherapy are indicated, but with symptomatic metastases and spontaneous fractures surgical intervention is indicated. This consists either of prosthetic replacement or of intramedullary fixation complemented by chemotherapy and radiotherapy.

Breast Neoplasms↗
PubMed1981

Diffuse skeletal angiomatosis.

Diffuse skeletal angiomatosis is a very rare syndrome. Since it was first observed by Shennan in 1915 only fifty-five cases have been reported in the literature (Rondier et al., 1977). It therefore seems that the description of a new case, accompanied for the first time by ultrastructural findings, may offer a new insight into the pathology of this disease.

Angiomatosis↗
PubMed1975

Dihydrotachysterol-induced aortic calcification. A histochemical and ultrastructural investigation.

Early dihydrotachysterol-induced calcification of the rat aorta occurs in elastic lamellae. The first deposition of inorganic substance leads to the formation of very thin filament-like structures of low electron density. The characteristic shape of these structures suggests that they could correspond to calcified filamentous components of the elastic tissue. When calcification spreads from the calcified elastic lamellae into the adjacent tissue, the inorganic substance is initially collected in roundish structures, probably of cellular origin, and is successively laid down in the entire matrix of the aortic wall, including collagen fibrils. All the calcified areas contain glycoproteins and acid proteoglycans. A cartilage-like tissue often develops near calcified areas. Its fine structure is very similar to that of the normal hyaline cartilage. It can be calcified, but usually the inorganic substance is not crystalline as it is in normal cartilage. It seems to consist of very small, linearly aggregated inorganic granules which form irregular structures. These seem to develop in close relationship with the fibrillar, probably collagenic, network of the matrix. No ultrastructural findings have been obtained for explaining cartilage induction near calcified areas of the aortic wall. It is possible that cartilage differentiation is regulated by diffusible substances which cannot be recognized under the electron microscope.

Animals↗
PubMed1973

Experimental calcification of the myocardium. Ultrastructural and histochemical investigations.

Focal areas of calcification are frequent in rat myocardium 30 and 60 days after administration of dihydrotachysterol. These areas are PAS-positive, stain deeply with alcian blue and show high affinity for colloidal iron. Calcification is almost completely confined to intracellular structures. Small clusters of needle-shaped crystals are first found in apparently undamaged mitochondria in undamaged myocardial cells. When all the mitochondria are calcified, the cell degenerates, and inorganic crystals are laid down in relationship with its myofilaments. In other myocardial cells, clusters of amorphous or finely granular inorganic substance are found in both mitochondria and myofibrils. Both structures show signs of advanced degeneration. Inorganic substance has only occasionally been found within the structures of the sarcoplasmic reticulum. These structures do not seem to be involved in myocardial calcification under the present experimental conditions. Calcification of myocardial cells gives rise to a cellular reaction. Many macrophagic cells surround the calcified areas, which are rapidly reabsorbed. The present results show that myocardial mitochondria are actively engaged in controlling the intracellular concentration and movement of calcium ions. Their role in the myocardial contraction-relaxation cycle and the possible mechanism of myocardial calcification are discussed.

Animals↗
PubMedDate not supplied

Lymphangioma of the thigh following acute trauma.

Only 2 cases of lymphangioma of traumatic origin have been previously reported, and in both it was a matter of repeated microtraumas. This is a report of a circumscribed lymphangioma in a 22-year-old man after a severe direct trauma of the thigh. Five months after the trauma a painless, slowly growing mass appeared in this area. Histologically, the removed mass appeared to be a combination of cavernous and cystic lymphangioma. The development of this lesion, which must be considered a hamartoma, may possibly be attributable to a traumatic hematoma and to subsequent reactive fibrosis which may have blocked the lymph drainage possibly from a sequestrated portion of the primitive lymphatic anlage.

Adult↗