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Biomedical subjects

R Salmon

Publications and source records attributed to R Salmon.

At least 19 recordsLinked to original sources
PubMed1992

Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial.

PURPOSE: A multicentric randomized study that compared patients who received intrahepatic arterial infusion (HAI) to a group of patients who did not receive HAI (control group) was performed for unresectable hepatic metastases from primary colorectal carcinoma. PATIENTS AND METHODS: One hundred sixty-six patients were assigned randomly to HAI of floxuridine (5 fluoro-2'deoxyuridine [FUDR]) 0.3 mg/kg/d for 14 days every 4 weeks or to the control group; this latter group, depending on the investigator's choice, was either under observation or received systemic fluorouracil (5-FU). The same regimen of systemic 5-FU also was administered to the HAI group in the event of extrahepatic progression. No crossover from the control group to the HAI group was permitted. The mean duration of follow-up was 54 months (range, 31 to 72), and 163 patients were analyzed. RESULTS: A significant improvement was observed in the survival rate for the 81 patients assigned to HAI group (P less than .02) with a 1-year survival rate of 64% versus 44% in the control group (82 patients). The 2-year survival rate was 23% versus 13%. The median survival was 15 months versus 11 months for the HAI group and the control group, respectively. Survival was better for patients with a less than 30% liver involvement, and for those treated in more specialized centers. The hepatotoxic effects of HAI were observed in 47 patients (chemical hepatitis [n = 28], and biliary sclerosis [n = 19]). The 1-year rate of sclerosing cholangitis was equal to 25%. Gastrointestinal toxicity was infrequent and consisted of gastritis or diarrhea. CONCLUSIONS: Therapy with HAI of FUDR improves the survival of patients with liver metastases over colorectal carcinoma. However, the methods that are used to diminish the toxicity of HAI and efficient systemic chemotherapy, such as a combination of 5-FU and leucovorin, are required to prevent extrahepatic metastases.

Colorectal Neoplasms↗
PubMed1992

[Familial adenomatous polyposis: early diagnosis by genetic mapping].

The use of probes detecting polymorphic loci within the human population has enabled accurate localization of the genetic defect responsible for familial adenomatous polyposis on chromosome 5. This was used to screen two families for the presymptomatic diagnosis in children of an affected parent. In both cases, the use of 8 polymorphic probes located on either side of the gene provided information which could be used in the management of children born from the patients at risk. The set of probes used in this work should be informative in most of the affected adenomatous polyposis families.

Adenomatous Polyposis Coli↗
PubMed1979

[Gastric ulcer: conservative surgical treatment in 100 patients (author's transl)].

One hundred patients with gastric ulcer underwent surgery without gastric mutilation by a technique initially directed against stasis by pyloroplasty, vagotomy and, according to the site of the ulcer, its limited resection or biopsy. In half of the cases, the indication was that of the development of a complication. Eight patients died, 6 of them from amongst the 44 haemorrhagic ulcers. Two deaths were favourised by a complication specific to the procedure used. 86% of the patients followed up had an excellent or good result. Six recurrences of ulcers were seen, including two which again recurred after gastrectomy. Morbidity and mortality, in particular in the case of bleeding, appear to be less after vagotomy than after gastrectomy. The long term results in terms of ulcer disease of the two methods are similar.

Drainage↗
PubMed1979

[Vascular complications of needle biopsy of the liver (author's transl)].

11 complications were observed in 2,346 cases of needle biopsy (frequency 0.47%) carried out in 1,529 cases under laparoscopy, 527 cases by the intercostal route, and in 290 cases during operation. The symptoms usually appeared early, indicating bleeding. The lesions, isolated or associated were six hemoperitoneums, and 9 hematomas (including 2 subcapsular), 3 intrahepatic (1 FAV), one of the gall bladder, 3 undetermined; 5 patients out of 11 were operated on, 4 out of 11 died. The place of surgical treatment is discussed: one hemoperitoneum led to early surgical operation. An intrahepatic or subscapular hematoma may regress without sequelae. An arteriography after a liver scan should eliminate a major vascular lesion which may eventually require surgery.

Adult↗
PubMed1979

[Lumbar hernia (author's transl)].

A case of lumbar hernia is reported here. The likelihood of the traumatic etiology of this case and the technics of parietal reparation are discussed. The risk of strangulation justify the preventive treatment.

Adult↗
PubMed1977

The causes of heroin addiction. A review of the literature. Part I.

The causes of heroin addiction have been studied and debated, and many theories have evolved. This article reviews the extensive literature on the subject and groups the material under the categories of Psychological, Pharmacological, Genetic, Socilogical, Social Protest, The Family, and Stepping Stone theories.

Anomie↗