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Biomedical subjects

R Santler

Publications and source records attributed to R Santler.

6 recordsLinked to original sources
PubMed1992

Do telangiectases communicate with the deep venous system?

Telangiectases of the legs occur frequently, with most patients seeking treatment for cosmetic reasons. Sclerotherapy continues to gain popularity as a safe and valuable therapeutic approach; however, deep vein thrombosis as well as pulmonary embolism have been reported even after sclerotherapy of small intradermal venectases. Hoping to uncover anatomic risk factors predisposing a patient to iatrogenic thrombosis, we investigated 15 patients with telangiectases of the legs applying ascending venography concomitantly with direct injection of the telangiectases. A digital radiographic technique was used as an imaging system. In two patients an unrestrained flow of the contrast medium into the venae femorales was noticed. As far as we know this is the first in vivo demonstration of venae communicantes connecting intradermal venectases to the deep veins. That means that particular anatomic conditions favor the spillage of sclerosant into the deep veins, which might contribute to the development of iatrogenic deep vein thromboses in compression sclerotherapy.

Adult↗
PubMed1975

[Trophic phenomena in dermatology (author's transl)].

After a description of trophic disorders in 2 patients the great variety of trophic disorders and their diagnostic problems are discussed. Neurovascular dysfunction may be the main cause of trophic phenomena. The general opinion ist that so-called "trophic" nerve fibres do not exist, but there is evidence of the production of "trophic" substances by the nerve endings. So long as these problems remain unresolved, the term "trophic" should be avoided in favour of "neurovascular disorder".

Aged↗
PubMedDate not supplied

[Fibrinolytic activity of the vein wall].

The author reviews this classically held opinion, that the older sclerosants cause coagulation of the blood, while the newer sclerosants bring about an endothelial change which itself generates a thrombus. He attempts to analyse the clotting activity of the vein wall before and after the sclerosant injection. The first series of experiments gave the impression that the walls of veins subjected to a sclerosant injection had an increased fibrinolytic activity, in comparison with untreated veins. It was noted that this increase in activity was not permanent but transient. Further studies have shown that this interpretation may be premature, since there are several possible sources of error. A new series of experiments is in progress, and it would be premature to draw conclusions.

Fibrin↗
PubMedDate not supplied

[Limitations of venous function diagnosis using laboratory apparatus - possibility of errors].

The authors discuss some questions concerning the limitations and the errors of methods involving the Sonar Doppler, Plethysmography and Phlebodynamics in phlebology diagnosis. The Doppler technique is the most useful one in detecting a valvular insufficiency or a venous obstruction of the thigh. Plethysmography is a simple method of detecting a pelvic or femoral thrombosis. It does not make it possible, on the level of the calf, to make a distinction between a recent thrombosis or a post-thrombotic state. It cannot be used when there is a large edema. It is inadequate for studying the function of the muscular pump of the calf, which can also be done by phlebodynamics. This method is now the most precise technique for quantitatively studying the total function of the muscular pump of the calf. It can be easily reproduced, and the effect of therapeutic measures can thus be anticipated.

Doppler Effect↗