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Biomedical subjects

R Sarel

Publications and source records attributed to R Sarel.

9 recordsLinked to original sources
PubMed1997

Evolving growth hormone deficiency in children with a subnormal secretion of growth hormone.

Three growth-retarded children with a normal growth hormone (GH) response to provocative tests, but subnormal 24-hour integrated concentrations of GH and insulin-like growth factor-binding protein 3 (IGF-BP3) are presented. Retesting 3 to 4 years later demonstrated a subnormal GH response to stimulation. The initial subnormal growth rate and IGF-BP3, despite a normal GH response to stimulation, may be secondary to a subnormal integrated concentration of GH.

Child, Preschool↗
PubMed1996

Growth of short children during and after discontinuation of growth hormone therapy.

We have attempted to evaluate the relationship between spontaneous growth hormone (GH) secretion and the response to GH therapy as well as the effect of discontinuation of GH therapy on further growth. The 24-h integrated concentration of GH (ICGH) was determined in 150 short children (< 2 SD for age) with a GH response to clonidine stimulation of more than 10 mcg/L. The patients were treated with GH for 4 yr and were observed for 1 yr following cessation of GH treatment. Twenty-two out of 52 patients who had an ICGH of less than 3.2 mcg/L (group LICGH) and 28 out of 60 patients who had an ICGH of more than 3.2 mcg/L (group NICGH) were followed without GH therapy. Only patients who remained prepubertal throughout the study were included in the analysis. The growth response of the LICGH to GH was better than that of the NICGH children. Patients regained normal growth velocity 6-12 months after discontinuation of GH therapy. Three children of the LICGH subsequently developed classic GH deficiency. These studies demonstrate that short-term GH therapy can improve the growth channel. Children with a low ICGH grow better on GH than children with a normal ICGH. Children with a low ICGH need continued observation and retesting when growth velocity is low.

Body Height↗
PubMed1991

Late appearance of thrombotic thrombocytopenic purpura after autoimmune hemolytic anemia and in the course of chronic autoimmune thrombocytopenic purpura: two case reports.

The association between thrombotic thrombocytopenic purpura (TTP) and autoimmune hematological conditions is reported in 2 patients. In a 35-year-old man, acute autoimmune hemolytic anemia (AIHA) was diagnosed in 1960; until 1965 he was free of disease, when he abruptly developed TTP and failed to respond to blood transfusions and corticosteroids. In a 14-year-old girl, autoimmune thrombocytopenic purpura (AITP) was diagnosed in 1981 and treated with corticosteroids and splenectomy. Four years later the patient was admitted with acute catastrophic signs and symptoms of TTP and failed to respond to plasmapheresis and plasma transfusions. The present case reports of associations between AIHA and AITP with TTP support the connection of the latter with abnormalities of the immune system.

Adolescent↗
PubMed1989

[Penicillin VK absorption during fasting and after eating].

The absorption of penicillin VK (Rafapen) was evaluated in 12 children, 3-16 years.old, with infections due to penicillin-sensitive organisms. In each, 50 mg/kg of Rafapen was given after an overnight fast, and the next day the same amount was administered after a standard hospital breakfast. Blood samples were drawn before and 30, 60 and 90 min after the drug was given. Serum penicillin levels were determined by comparing the inhibition of growth on plates of Staphylococcus aureus (Oxford strain), with that of standard penicillin G concentrations. The serum levels after the overnight fast were higher, 4.75 U/ml, as compared to 3.38 U/ml 30 min after the drug was given following breakfast. This increase was abolished at 60 and 90 min, when the serum levels were 1.96 and 1.05 U/ml, respectively. We advise the use of oral penicillin VK in infections due to penicillin-sensitive organisms, without regard to feeding schedule.

Administration, Oral↗
PubMed1982

Facial reconstruction in partial lipodystrophy.

Lipodystrophy is a rare disease characterized by progressive disappearance of the subcutaneous fat of the upper part of the body. Accompanying abnormalities of carbohydrate and lipid metabolism, diabetes, nephritis, and low levels of complement are frequent. The most striking clinical features are the extremely hollow cheeks, making the normal facial skeleton rather prominent. Very little has been reported on facial reconstruction in such patients. A 16-year-old girl is presented who was successfully reconstructed after the atrophic process arrested spontaneously. Bilateral dermal fat grafts from the buttocks were used in a one-stage procedure. Nine months later, when no more resorption of fat occurred, some trimming of the grafts was necessary. A good result was achieved.

Adipose Tissue↗
PubMed1980

Puberty in Laron type dwarfism.

The onset and progress of puberty was followed in 18 patients (7 males and 11 females) with Laron-type dwarfism (LTD). The boys had delayed puberty, testicular enlargement occurring between 12--14 years being the first sign. The first conscious ejaculation occurred between 17--21 years and full maturity was reached after the age of 22. In girls menarche occurred between 13--14 years and full maturity was reached between 16-19 years. Two patients--one male and one female--have children.

Adolescent↗