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Biomedical subjects

R Schütz

Publications and source records attributed to R Schütz.

At least 19 recordsLinked to original sources
PubMed1989

[Cibenzoline: electrophysiologic effects of a new class I anti-arrhythmia agents in supraventricular tachycardia].

Cibenzoline, an imidazoline derivate, is a new class 1 antiarrhythmic agent. The electrophysiologic effects and antiarrhythmic properties of cibenzoline (100 mg i.v.) were evaluated in 22 patients with paroxysmal supraventricular tachycardia: 12x Wolff-Parkinson-White Syndrome, 9x AV nodal reentrant tachycardia, 1x atrial tachycardia. Cibenzoline shortened the sinus cycle length from 742 +/- 103 ms to 661 +/- 87 ms (p less than 0.001) and the sinus node recovery time from 1026 +/- 106 ms to 926 +/- 135 ms (p less than 0.001). The substance lengthened the AH interval from 93 +/- 19 ms to 112 +/- 24 ms (p less than 0.001) and the HV interval from 42 +/- 12 ms to 61 +/- 14 ms (p less than 0.001). The effective refractory periods of the atrium and right ventricle did not change significantly, but the effective refractory period of the AV node in antegrade (269 +/- 42 ms vs 278 +/- 46 ms; p less than 0.05) and retrograde direction (281 +/- 57 ms vs 413 +/- 124 ms; p less than 0.001) increased markedly. Cibenzoline prolonged the effective refractory period of the accessory pathway in retrograde direction from 263 +/- 41 ms to 428 +/- 101 ms (p less than 0.001). The effective refractory period of the antegrade accessory pathway did not change. During atrial stimulation inducibility of the reentrant tachycardia was suppressed in 14 of 22 patients and the inducibility of atrial fibrillation in 7 of 12 patients. The RR interval of the reentrant tachycardia was prolonged from 353 +/- 57 ms to 420 +/- 57 ms (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

[Contact allergy to rubber, surgical and vinyl gloves].

Thirty-one patients with a contact allergy to gloves made from rubber or vinyl were investigated in a retrospective and prospective study. Sensitivity to rubber gloves used in the household and in industry occurred most frequently (64%), followed by surgical gloves (26%) and vinyl gloves (10%). Health service worker and housewife were the professions in which the allergy was most frequently present. The main sensitizers were found to be the rubber accelerators of the thiuram and carbamate group. A series of various gloves (household, surgical, vinyl) yielded extremely different results when tested epicutaneously on the rubber-sensitized individuals. Vinyl gloves, surgical gloves made from pure latex or surgical gloves with an inner plastic coating may alternatively be used by these patients.

Dermatitis, Contact↗
PubMed1986

[Group occupational medicine of the Swiss Accident Insurance Institute ].

According to the Swiss Federal Accident Insurance Law, the Swiss National Accident Insurance Company (Suva) is responsible for the prevention of occupational disease in all Swiss industries. In the Suva medical division, a special group concerned with occupational medicine ensures that these measures are implemented. It first of all organizes and supervises preliminary check-ups and follow-up examinations and then may also exclude endangered employees from their present activity. Such employees are entitled to free advice and in certain cases may qualify for interim daily allowances.

Air Pollutants, Occupational↗
PubMed1982

[Immunological staging in lupus erythematosus. Basic data and practical significance].

A complete staging of immunity in lupus erythematosus includes immunoserologic, immunocytologic, and immunohistologic findings. However, not all of these laboratory findings are of clinical relevance. The most important immunologic parameters for lupus erythematosus can be summed up in three obligatory and two facultative tests. This "immunologic staging" is considered to be of decisive importance for the risk classification of patients with lupus erythematosus and for the choice of the therapeutic procedure.

Antibodies, Anti-Idiotypic↗
PubMed1982

[Side-effects of atropine: pharmacological, allergic, pseudo-allergic or toxic reactions?].

Between 1979 and 1981 31 children aged from one to 14 years who had been given atropine eye drops to measure refraction presented with the following side-effects: increased temperature (9/31), dry red skin (8/31), reddened eye (3/31) and periorbital dermatitis (2/31) after single (22/31) or repeated (9/31) administration of atropine. In the epicutaneous test with atropine eye drops 1% (readings after 24, 48 and 72 hours) not a single child showed an allergic or toxic reaction. The rarity of an allergy after administration of atropine drops is emphasized by the fact that periorbital dermatitis was observed in only two cases. Clinical experience shows that incipient allergy owing to the anatomical structure of the conjunctiva and eye lids first becomes apparent in the region of the eye, even if the epicutaneous test is not necessarily positive in the dorsum skin. In view of the necessity of administering atropine prior to emergency surgery it is advisable to carry out epicutaneous tests if side-effects have been observed in the eye, to make sure that the patient is not allergic to the drug.

Adolescent↗
PubMed1979

[The LE cell phenomenon. New aspects in molecular biology and immunocytology].

1. The effects of antinuclear antibodies on nuclear material can be observed directly in free leucocyte nuclei in the supravital preparation according to Engel. 2. The antinuclear antibodies prevent the lysis of free nuclei, they obstruct the normal degeneration of nuclei. 3. The nuclear blockade is recognizable in the dark-clodded, rigid nuclei which remain small. These blocked nuclei are the visible expression of a development of complexes between chromatin and antinuclear antibodies. 4. It is supposed that the protective effect of antinuclear antibodies consists of the obstruction of the DNases and histon-proteases bound to chromatin. 5. The effects of antinuclear antibodies is in agreement with the structure of the nucleosomes of chromatin. 6. The nuclear blockade caused a persistence of antigenic material, which can create an increase of antibody production. This means that in vivo the antinuclear blockade is an effect which sustains illness.

Antibodies, Antinuclear↗
PubMed1979

[Nucleophagocytosis in monocytes--an immunocytologic phenomenon of anti-dna-antibodies].

In SLE-sera antinuclear antibodies pervent normal nuclear degeneration, i.e. lysis of free nuclei. In sera with high titers, small rigid LE-bodies develop rapidly, which are soon phagocytized in toto by neutrophil granulocytes and monocytes. Classic LE-cells as well as Tart-cells are formed. The foreign appearance of the phagosomes in the monocytes is a result of the different digestive processes occuring in these phagocytes. With decreasing serum activity, the LE-bodies expand somewhat more and become viscous. From these nuclei, relatively small portions are phagocytized fairly late. Sjögren-cells of the granulocytic as well as the monocytic type are generated. Nucleophagocytosis only occurs in the presence of antinuclear antibodies, regardless of whether it leads to LE-cell, Tart-cell or partial phagocytosis, i.e. Sjögren-cells of the granulocytic or monocytic type. A non-specific nucleophagocytosis does not exist.

Antibodies, Anti-Idiotypic↗
PubMed1975

[Evaluation of the quality of diagnostic examinations in ambulatory patients].

100 medical records of male and female patients seen for the first time in 1972 at the Medical Outpatients Department, University of Basel (Switzerland) were reviewed retrospectively to assess the quality of history and clinical as well as laboratory diagnostic procedures. In addition, 10 patients were selected for total re-evaluation by renewal clinical and laboratory examinations. On the basis of entries made in the medical records (format DIN A5) the medical history and the clinical examination were judged to be of good quality. A minimal program for laboratory investigation (sedimentation rate, hemoglobin, leukocyte count, serum-transaminase, BUN, urine for sugar and albumin and urine sediment) and small format chest-X-ray had been carried out according to the rules and supplement by additional investigations in 87%. The retrospective check on 10 patients showed that the first examination had been well done and without omissions. Continuous checking of diagnostic procedures was recognized as important, and changes in the forms used were admitted to be necessary for improving quality.

Ambulatory Care↗