Chemical contaminants in human serum albumin: presence of glucose and ethanol in freeze-dried or ultrafiltered products.
Glucose and Ethanol are determined in final Human Serum Albumin solutions, obtained by two different processes: freeze-drying (FD) and ultrafiltration (UF). The elimination rate for glucose is higher than that for ethanol in case of ultrafiltration. The concentration of both "contaminants" seems to be much lower by UF than by FD. From these data arises the question of a limit-value for fractionating agents, in the final product. In the case of FD process, as the reagents remain in the product final, they all must be strongly controlled. As a large part of small molecules can be eliminated by UF process, it permits to seek new reagents for protein separation.
Blood Glucose↗