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Biomedical subjects

R Schrage

Publications and source records attributed to R Schrage.

At least 19 recordsLinked to original sources
PubMed1991

[Cancer register problems--modified reporting law model for the improvement of data protection].

The author suggests creating a "Reporting Law Model with Peripheral Part Anonymisation" that preserves the advantages of the reporting law model which are internationally recognised in respect of reliability of registration, on the one hand, while on the other hand the general and individual requirements of sufficient protection of sensitive data are also taken care of. This is achieved by separating the personal data from the factual data at the reporting office level. These data are transmitted separately to the registration offices and their confidential files. It is nevertheless possible to detect any double or multiple reporting and to perform fault finding in respect of personal data. It is also possible to add further data to any patient's case history. This cancer registration model can always cope with the required descriptive and analytical epidemiological tasks that are expected of it. It can be arranged to cover a wide area in a continuous manner without loss of time and without considerable expenditure. Documentation work to be performed by the reporting offices is minimised.

Confidentiality↗
PubMed1985

[Chlamydia trachomatis--studies on the reliability of its detection in Papanicolaou preparations].

In a matched group of 104 chlamydia culture-positive and 104 culture-negative women, the correlation between simultaneous cultures and cytological findings in the Papanicolaou smear was studied. Cellular changes in metaplastic cells that are described in the literature as being specific for Chlamydia trachomatis, were not associated with genital chlamydial infection. In particular the reported high sensitivity of intracytoplasmatic inclusion bodies could not be confirmed. Likewise, even severe inflammatory changes and a high concentration of lymphocytes were also no reliable diagnostic indicator. The authors conclude that the Papanicolaou smear is not useful as a routine screening method for genital chlamydial infection.

Adult↗
PubMed1978

[Problems of current diagnosis of neoplasms in women].

The value of early cancer detection in women is limited by the screening methods and their minor reliability in "mass-screening". The effect of detection programs is difficult to demonstrate. The interest in cancer detection is low, especially in elderly high risk patients. A more suitable application of screening tests with widespread indication of further methods together with exact demonstration could be the basis for better results in early cancer detection programs in women.

Adult↗
PubMed1976

[Results of cancer screening in women (author's transl)].

The results of cancer screening in women were evaluated from 1,1 million investigations during the third quarter of 1971 to the second quarter of 1974. Positive cytological results of the uterine cervix were found in 0,39% on first investigation and in 0,38% on repeat investigations. Positive results in the breast amounted only to a quarter (0,1%) of the frequency of positive cytological results despite the fact that breast cancer occurs more frequently than cervical carcinoma. Only 0,03% positive findings were obtained by digital rectal palpation. The low incidence of the diseases sought for and the partly low sensitivity of the screening methods are responsible for the small numbers of positive findings in early detection investigations and are an indication of the effort involved. Participation of the population in investigations for early detection of cancer is unsatisfactory especially in older age groups with an increased risk.

Adult↗
PubMed1976

[The diagnosis of corpus carcinoma (Differentialdiagnostic importance of history- and clinical criteria in post-menopausal hemorrhage) (author's transl)].

Among 1554 patients with post-memopausal hemorrhage over 7 years one half were due to benign causes, the other in almost equal parts to carcinoma of the fundus or cervix. Ca of the fundus is more likely when post-menopausal bleeding occurs at a relatively old age, a late menopause and a long interval between menopause and post-menopausal bleeding. Nulliparae more often have Ca of the corpus than in the cervix or have benign changes. The trias known for the corpus Ca: adiposity, diabetes and hypertension is confirmed. An enlargement or softening of the uterus and myomatous changes also indicate Ca. Anatomical and clinical criteria permit not only a detailed assessment of post-menopausal bleeding but also a definition of cases at risk before bleeding occurs and give an indication for detailed investigations.

Age Factors↗
PubMed1976

[Are more girls than boys born in breech presentation compared with head presentation?].

In breech presentations a little more girls are born than boys, among head presentations there is a slight excess of boys. Among the factors favoring pelvic presentation birth weight has, according to present investigations, a decisive influence on the different sex relationship in the two presentations. Boys are little more common than girls in head presentation in the higher weight groups, in breech presentation in the upper and lower weight groups, while girls predominate in the middle weight groups. The absolute size of the middle weight groups in breech presentation causes the small excess of girls. A possible link with the slightly higher mortality of boys during the first year and its higher incidence in very high and very low weight groups are discussed as well as the dependence of the production of breech presentation on weight and mobility of the fetus.

Birth Weight↗
PubMed1975

[The timing of tubal ligation (Author's transl)].

In spite of medical or mixed medical and social indications, the sterilization by tubal ligation is frequently not carried out or done very late as in sterilization combined with a therapeutic abortion. This is borne out by the review of case histories and consultations of patients who had a sterilization operation other than post-partum, multiparous patients who had no sterilization, multiparous patients who had sterilization post-partum and patients who had an application for therapeutic abortion rejected and patients who had a therapeutic abortion with concomitant sterilization. The medical indications, medical social indications, the duration of the disease, the desire for child bearing, the social conditions and the family conditions were of such nature that in 29-80 percent of the cases under review sterilization could have been carried out at an earlier time. The relatively high incidence of women who presented with indications for sterilization but whose sterilization was delayed shows that more active individual counseling regarding sterilization by the attending physician is desirable. If necessary the physician should raise the question of sterilization and discuss the problem with the patient. This type of counseling would insure that the patient can make an informed decision and would minimize the psychological side effects and after-effects of sterilization.

Abortion, Legal↗
PubMed1975

[Urocytogram in the treatment with bleomycin].

Even though Bleomycin is excreted in the urine in high concentrations, side effects in the urinary tract due to the chemical nature of this compound are seldom observed. With respect to treatment of gynecological carcinomas, it is, therefore, important to examine the effect that Bleomycin when treatment involves the use of Endoxan. Cytologically, one finds an increase in desquanmation of the transitional epithelium and an increase in degenerate cell forms. The homogenous eosinophilic cellular inclusions which are observed, are specific for neither Endoxan nor for Bleomycin treatment. The antibiotic effect of Bleomycin results in an aseptic cystitis. The urocytogramm is suitable for examining the epithelial changes of the urinary tract in context with the gynecological carcinoma treatment and also for determing tumor breakthough into the bladder.

Bleomycin↗