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Biomedical subjects

R Schrieber

Publications and source records attributed to R Schrieber.

4 recordsLinked to original sources
PubMed1993

Gelatine production, the six steps to maximum safety.

Gelatine production is described in detail, from the slaughterhouse where the raw material for gelatine manufacturing is collected, through the processing treatment, to the final product which is ready for pharmaceutical or edible purposes. The influence of the veterinary inspection of the animal, the batch size of the production, the degreasing and acidulation process for bones and the different possibilities of the alkaline treatment of hide splits and ossein followed by the sterilization steps during the final gelatine manufacturing are discussed with regard to the potential destruction of a theoretical BSE infection. The question is raised to what extent further activities of the gelatine industry seem to be necessary.

Animals↗
PubMed1984

Systemic effects of methylcholanthrene in mice. I. Splenic and hepatic phagocytosis of xenogeneic red cells.

Male and female mice of strains C3H/eB and C57BL/6 were injected subcutaneously with methylcholanthrene (MCA) dissolved in olive oil; mice injected with olive oil served as controls. After intervals of from 2 to 13 weeks, experimental and control mice were injected intraperitoneally with 51Cr-labeled rat red cells (RRC) and killed 24 h later. Radioactivity assayed in spleen and liver and expressed as percent of total-body radioactivity served as indicator of phagocytic uptake. Significant decreases in splenic and, to a lesser extent, hepatic phagocytosis were observed at some time intervals in all strain-sex combinations, except for female C57BL/6 mice. The phagocytic activity of untreated C57BL/6 mice exceeded that of C3H/eB mice. Phagocytosis was greater in female than in male C3H/eB mice. In the experimental design employed, no direct correlation was apparent between impairment of phagocytosis and resistance to carcinogenesis.

Animals↗
PubMed1984

Thymic hormonal effect on recovery from early and late CCNU induced immunosuppression.

The alkylating agent 1(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) caused a prolonged suppression of antibody response to sheep red blood cell challenge in mice. Two phases of suppression could be observed, an early (first three weeks after CCNU administration) and late phase (4-10 weeks). The late immunosuppression was more severe than the early one. Treatment by the thymic extract thymostimulin (TP-1R) caused a complete recovery of antibody response, with overshoot, during early phase, but only partial recovery during late phase. It is suggested that the known CCNU induced damage to stem cells, manifested at late phase, reduces the responding pool for the restorative effect of thymostimulin.

Animals↗