PubMed Health⌕ Search

Biomedical subjects

R Schuppli

Publications and source records attributed to R Schuppli.

At least 19 recordsLinked to original sources
PubMed1985

[Prevalence of antibodies against HTLV-III in various regions in Switzerland].

Acquired immune deficiency syndrome (AIDS) has been etiologically linked with the human T-cell lymphotropic virus HTLV-III. In a study on the prevalence of antibodies to this virus in Switzerland, sera from 941 individuals were collected in 5 major urban areas (Basel, Berne, Geneva, Lausanne and Zurich) in 1983 and 1984. All sera were tested by ELISA and the majority also by Western blot. We found an antibody prevalence of 100% among 22 cases of AIDS, of 94% among 48 cases of AIDS-related complex (ARC), and of 57% among 14 homosexual contacts of AIDS patients. Among 55 sera collected from i.v. drug addicts in 1984, 53% were positive, whereas the rate had been 36% among 103 sera collected in 1983. The rate was 19% among 227 sera collected from asymptomatic active homosexuals in 1984, against 10% among 40 sera collected in 1983. 8% positives were found among 98 patients with various types of viral hepatitis. In addition, 4% of 84 sera of individuals from Equatorial Africa were positive. No positives were found among 15 sera of individuals from other African regions, among 32 sera of persons from various regions of Asia, and among 203 Swiss blood donors. These results demonstrate the high and increasing rate of HTLV-III infection among groups at risk for AIDS, and suggest that HTLV-III-related diseases will be a serious problem in the years ahead.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Value of the lymphocyte transformation test for determining immune status].

Studies on lymphocyte stimulation in vitro were carried out with various perspectives. Apart from the well-known mitogens such as PHA and ConA, Candida extract and mercury ions had a relatively strong stimulatory effect, mistletoe extract a moderate one, nickel ions and trichophytin none at all. In malignant lymphomas the degree of stimulation was greatly reduced. In malignant melanomas the degree of stimulation, which at the beginning was often quite low, increased during the course of treatment. There was no correlation between the response to recall antigens and the degree of lymphocyte stimulation. The lymphocyte stimulation test did not prove reliable for the detection of drug allergies.

Drug Hypersensitivity↗
PubMed1976

Is mycosis fungoides an "immunoma'?

New knowledge of the function and biological behaviour of the cells of the lymphocytic system justifies a critical reappraisal of the nature and origin of mycosis fungoides (MF). The fact that in MF the immune response remains active during the whole course of the disease distinguishes it from other malignant processes. On the basis of the well-known fact that chronic stimulation of the immunological system may lead to tumour formation, the hypothesis is stressed that MF may be an "immunocytoma' or 'immunoma'. New findings indicate that immunological stimulation of lymphocytes may lead to the formation of endogenous oncogenic viruses. All these questions should be investigated in as many centres as possible.

Animals↗