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Biomedical subjects

R Schwenke

Publications and source records attributed to R Schwenke.

18 recordsLinked to original sources

[Catamnestic studies of the significance of synovial membrane needle biopsy for the diagnosis of rheumatic disease].

By means of a catamnestic study diagnostic evidence, number of complications and examination-conditioned stress of the patient caused by needle biopsy of the synovial membrane were tested. 4-11 years after a blind biopsy of the synovial membrane carried out on account of rheumatological indication 80 patients (48 males, 32 females) were examined and the results of the preliminary examination and the secondary examination were compared with the findings of the needle biopsy of the synovial membrane. While the needle biopsy of the synovial membrane in rheumatoid arthritis has a high diagnostic value in comparison to clinical and paraclinical findings, in the histomorphological ascertainment of the uric arthritis the catamnestic study shows the limits of the method due to place-depending differences of the findings of the crystalline deposit in the synovial membrane. The number of complications of the investigation technique was insignificant and had no influence on the duration of the inability to work. As a highly specialised diagnostic method the blind biopsy of the synovial membrane may contribute to the clarification of problem cases in institutions with rheumatological profile without possibility of arthroscopy.

Adult↗

[Case report on osteoarthropathy following frostbite].

On the basis of a casuistics of a 38-year-old male is reported on osteoarticular changes after local congelation. 10 years after a second- to third-degree injury of the right hand the patient was admitted to the dispensary for rheumatism under suspicion of a rheumatoid arthritis. Differential-diagnostic aspects and reports in literature on the clinical as well as radiological variation of the course of local congelations are discussed. Here the large temporary intervals between local frost injury, early and late clinical and radiological symptoms with 3 and 10 years, respectively, are conspicuous and little known.

Adult↗

[Outpatient care in uric acid disorders].

In 35 patients with uricopathy (arthritis urica, essential hyperuricaemia) the serum uric acid values, consumption of alcohol, overweight, hypertension and liver enzyma under dietary and medicamentous therapy (allopurinol) were investigated. Here during an observation lasting 12--48 months allopurinol proved as a well tolerable uricostatic drug which was sufficiently effective also with a considerable exogenic purine application. We only insufficiently succeeded in influencing overweight and alcohol consumption as well as hypertension by rheumatic dispensary care and family doctor.

Adult↗

[The content of lysosomal enzymes in the synovial membrane affected by a rheumatoid process and in the normal orthological one].

The activity of lysosomal hydrolases in biopsy samples of the synovial membrane taken from patients with rheumatoid arthritis gives an idea about the local activity of the process. This agrees with the histological picture of the synovial membrane. It has been established that the enzymatic activity depends on the site of the puncture for taking biopsy material.

Acetylglucosaminidase↗

[Reflection of local inflammatory activity in rheumatic diseases in synovial imprint cytology].

Cytological signs of the synovial imprint preparation have been correlated with findings of systemic, histomorphologic and arthroscopic inflammatory symptoms in 123 patients with rheumatic arthropathies. Out of the observed cellular and non-cellular structures of the synovial imprint cytology, fibrin, fibrinous necroses and relations of neutrophil polymorphs, as well as synovial phagocytes, reflect the acute inflammatory activity of the joint examined. The content in synovial imprint preparation of cells and cell groups are manners of expression both of the acute and proliferative activity as well as basic activity, respectively, of the synovial membrane. The synovial imprint cytogram's number of giant cells correlates with the histomorphologic degree of severity of the local proliferative inflammatory activity. Correlations between the level of the 1-h-value of the erythrocyte sedimentation rate (ESR) and the imprintocytological finding cellular distribution density, as well as relations between synoviocytes and neutrophil polymorphs, had to be demonstrated statistically. No correlations, however, were found between cytologic structures of inflammatory activities of the synovial imprint cytogram and the differential cell picture of the associated serosynovitis.

Arthritis, Infectious↗