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Biomedical subjects

R Seitz

Publications and source records attributed to R Seitz.

At least 109 records · Page 6Linked to original sources
PubMed1985

Cardiomyopathy associated with Leigh's disease.

Clinical and postmortem findings in a female infant, suffering from Leigh's disease and cardiomegaly are described. The cardiac enlargement was due to symmetrical thickening of both ventricular walls and the septum. On light microscopy a widespread fibre disarray with a slight predilection for the ventricular septum was observed. Ultrastructural changes included an extreme reduction in the number of myofibrils and an excess of mitochondria. Abnormalities of the mitochondrial structure with tubular and myelinic transformation of the cristae suggested that a mitochondriopathy is responsible for the cardiomegaly in Leigh's disease.

Autopsy↗
PubMed1985

The clinical significance of alpha 1-antitrypsin-elastase (alpha 1AT-ELP) and alpha 2-antiplasmin-plasmin (alpha 2AP-PL) complexes for the differentiation of coagulation protein turnover: indications for plasma protein substitution in patients with septicaemia.

In inflammation, particularly in septicaemia, complex coagulation disorders may lead to a dangerous haemorrhagic diathesis. The conventional concept for this syndrome called DIC implicates the occurrence of active thrombin in the circulation, which may be followed by hyperfibrinolysis due to plasmin formation. In this study data are presented suggesting an important role for a third proteolytic system, granulocytic elastase. The complexes of plasmin and elastase with their specific inhibitors, alpha 2-antiplasmin-plasmin (alpha 2AP-PI) and alpha 1-antitrypsin-elastase (alpha 1AT-ELP) were determined immunologically. The alpha 1AT-ELP appears mainly in gram-negative septicaemia, particularly in meningococcal disease. The estimation of alpha 2AP-PI and alpha 1AT-ELP, together with a method for the detection of the antithrombin III--thrombin complex which remains to be established, is a suitable tool for for the differential diagnosis of the consumption of coagulation proteins. The assumption that at least three proteolytic systems participate in the development of the haemorrhagic diathesis during inflammation leads to the concept of a broad, comprehensive substitution therapy with e.g. concentrates of AT III, PPSB, or fresh frozen plasma. The aim of this treatment is to replace not only the consumed procoagulatory factors, but also the lacking inhibitors in order to control this "abnormal proteolysis syndrome".

Adult↗
PubMed1985

Impaired fibrinolysis after kidney transplantation.

Impaired fibrinolysis is associated with low plasma plasminogen (PLG) and a predominance of its inhibitor alpha 2-antiplasmin (APL). Plasma PLG and APL were determined in 10 recipients who retained their cadaveric graft (A) and 10 patients who lost it immediately after transplantation (B). In group A only five patients had a PLG less than 70 per cent and/or APL/PLG ratios exceeding 1.8, accompanied by severe albeit reversible acute rejection in three of them. In contrast nine of 10 group B patients had low PLG and/or an elevated APL/PLG ratio. Thus impaired fibrinolysis frequently appears to be associated with deterioration of cadaveric graft function.

Adult↗
PubMed1983

[Hepatocellular drug reaction caused by mebendazole therapy in cystic echinococcosis].

A 76 years-old male patient received mebendazole, 500 mg four times a day (appr. 29 mg per kg body weight) for treatment of sonographically and serologically proven cystic echinococcosis of the liver. On day 49 of this therapy he developed an exanthema, and mebendazole-administration was interrupted. At the same time a striking rise of serum transaminases was observed. When enzyme levels normalized, a reexposure using a low dose of mebendazole lead to a new more pronounced rise of transaminases suggesting a drug-induced hepatocellular damage. No measurable change of the Echinococcus cyst was observed during treatment.

Aged↗
PubMed1983

[Therapy of patients with severe liver insufficiency using antithrombin III and plasma derivatives].

The treatment of three patients suffering from carbon tetrachloride intoxication with antithrombin III and plasma derivatives is reported. In these patients an acute liver failure had been proven, characterized by a disturbed protein synthesis and a severe haemostasis defect. The latter manifested itself by a consumption of platelets, clotting enzymes and the inhibitors antithrombin III and alpha 2-antiplasmin. It was due to an intravascular coagulation leading to disturbances in the microcirculation. This often letal circulus vitiosus could be stopped in these patients by treatment with antithrombin III concentrate combined with low dose heparin and fresh frozen plasma. Clinical improvements are discussed on the basis of the pathophysiology of the liver.

Adult↗
PubMed1982

[Arrhythmias in poisoning with tricyclic antidepressive agents. Successful treatment with physostigmine and sodium].

A 26-year-old female patient was admitted 30 minutes after suicidal poisoning with 750 mg amitriptyline (Saroten), 4800 mg dibenzepine (Noveril retard) and 2100 mg thioridazine (Melleril). Life threatening disturbances of cardiac rhythm occurred in addition to coma, pulmonary insufficiency requiring assisted ventilation, and hypotension. Physostigmine only caused temporary improvement and the arrhythmias only resolved completely after additional administration of NaCl.

Amitriptyline↗
PubMed1981

Ependyma and meninges of the spinal cord of the mouse. A light-and electron-microscopic study.

In addition to ependymal epithelial cells, numerous tanycytes are found along the entire central canal of the mouse. These tanycytes are arranged in clusters in the cervical, thoracic and lumbar segments of the spinal cord. In the conus medullaris, tanycytes separate and ensheath bundles of myelinated and unmyelinated axons; their processes take part in the formation of the stratum marginale gliae. In the caudal part of the spinal cord, the ventral wall of the central canal is thin and some areas are reduced to a single-cell thickness. In this region, ependymal cells participate directly in the formation of the stratum marginale gliae. The meninges consist of the intima piae, the pia mater, the arachnoid, a subdural neurothelium and the dura mater. The subarachnoid space appears occluded and opens only around the spinal roots. In the vicinity of the spinal ganglia, the dura mater, the subdural neurothelium and the arachnoid form a cellular reticulum.

Animals↗
PubMed1981

Severe chlorate poisoning: report of a case.

A case of severe sodium chlorate poisoning was observed within 5 h after suicidal ingestion of 150-200 g of the herbicide. Methaemoglobinaemia was the early symptom of the intoxication. Treatment with methylene blue and ascorbic acid could not prevent a massive haemolysis with disseminated intravascular coagulation. Hypercoagulation and hyperfibrinolysis could be treated successfully with exchange transfusions, heparin and fresh plasma. During the first hours, 70 mmol chlorate were excreted before complete renal failure occurred which required haemodialysis for several weeks. Clinical observations and in vitro experiments provide evidence that methylene blue is effective only in the very early stages of chlorate poisoning. Consequently, the following treatment is suggested: gastric lavage, exchange transfusion, bicarbonate infusion, haemodialysis, anticoagulation with heparin and substitution of clotting factors if necessary.

Adult↗
PubMed1980

Studies on megakaryocytes: isolation from rat and guinea pig and incorporation of 5-hydroxytryptamine.

A new, two step method is described for the isolation of megakaryocytes from bone marrow. By means of centrifugation in a PercollR density gradient megakaryocytes can be enriched by factor 68 or 24 starting from rat or guinea pig bone marrow, respectively. The purity of the megakaryocytes can be improved ca. 4 fold if gradient centrifugation is followed by separation in an Elutriator rotor.-The isolated megakaryocytes take up exogenous 5-hydroxytryptamine with a time and concentration dependent transport mechanism, K11=30 micrometer, K12=1.5 micrometer. As shown by electron microscopy the number and density of storage granules within the megakaryocytes is enhanced after incubation with 5-hydroxytryptamine. This finding suggests that 5-hydroxytryptamine is incorporated into the organelles.

Animals↗
PubMed1979

[Operation on a congenital cataract in a Siberian Tiger].

A cataract operation in a young Siberian tiger is reported. This 5-month-old tiger, presenting with blindness, showed bilateral residual pupillary membranes and anterior polar cataracts combined with nuclear cataracts. After unilateral intracapsular extraction of the lens, the tiger adapted well to the improvement in sight and behaved almost like an animal with normal vision. The animal died 3 months post-operatively from unknown cause. Histological examination of the aphakic eye showed, at the site of operation on the cornea, an intact epithelium with discrete infiltration of the stroma together with low-grade vascularisation. In the eye not treated operatively, both an anterior polar cataract with adherent pupillary membrane strands and a central cataract were seen. Of particular note, when comparing this large wild cat with the domestic cat, was the marked development of the tapetum lucidum (up to 30 cell layers).

Animals↗
PubMed1976

Aberrant nerve fibre bundles in the retina of the dog.

Systematic ophthalmoscopic examinations of 2511 Beagles, test animals in 72 long-term toxicological studies, showed archiform thin white stripes in the fundi of 98 animals (3.9%). The stripes occurred in one or both eyes in the non-tapetal fundus of the two lower quadrants. Examinations of the fundus of some dogs by fluorescence angiography and ophthalmoscopy with red-free light showed that these fibriform stripes were in the retina. Histological examination showed these stripes to be nerve fibre bundles (5-120 axons) lying at the ganglion cell layer. The ultrastructure of the fibres did not differ from that of the nonmyelinated neurites of the fibre layer. The stripes may be retinal nerve fibres with a normal structure but could be distinguished from fibres of the nerve fibre layer by their intraretinal location and by their course.

Animals↗