Hyperinfection with strongyloides.
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Biomedical subjects
Publications and source records attributed to R Seymour.
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Clomipramine was significantly superior to placebo in a 10-week double-blind, placebo-controlled trial in 27 outpatients who met DSM-III-R criteria for obsessive-compulsive disorder.
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In recent years it has become abundantly clear that health professionals are at high risk for addiction to drugs and alcohol. Addiction is here defined as compulsion, loss of control, and continued use in spite of adverse consequences. Obviously health professionals with these symptoms are dangerous both to themselves and to their patients. Destigmatization at the community level, identification of addicts, intervention, and diversion into treatment are important factors in dealing with the problem. Programs for diversion and support are being developed in California for impaired physicians, nurses, and pharmacists. These are replicable elsewhere for helping impaired health professionals.
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Over the last decade, bone scans have played an increasingly important role in the management of patients with breast carcinoma; by detecting both occult and symptomatic bony metastases. 234 bone scans carried out in this hospital in 1978/79 on patients with breast cancer, at considerable cost to the NHS, are reviewed.
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Right heart catheterization was performed in ten patients with pulmonary oedema. Mean wedge pressures in excess of 12 mmHg above the mid-axillary line were regarded as abnormal and indicating left heart failure. If the wedge pressure was less than 12 mmHg, and pulmonary congestion was present, frusemide was given. Brief descriptions of the ten cases are given.
Eight acromegalic patients showed a plasma cortisol (11-OHCS) rise after insulin hypoglycemia which was similar to that seen in control patients, with mean peak values (+/-SEM) of 23.2 +/- 3.5 mug/100 ml and 27.2 +/- 3.3 mug/100 ml, respectively. One mg of dexamethasone was given the evening prior to repeat insulin hypoglycemia (DEX-ITT). After dexamethasone, the control subjects showed a mean post hypoglycemic plasma 11-OHCS rise to 18.3 +/- 2.3 mug/100 ml. In contrast, acromegalic patients had a negligible rise is plasma 11-OHCS, despite a comparable degree of hypoglycemia. These data indicate that, in active acromegaly, abnormal hypothalamic-pituitary-adrenal suppressibility can be induced to insulin hypoglycemia after dexamethasone.
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A random sample of community dwelling elderly people (> 65 years) was interviewed on two occasions, 6 months apart. Four hundred and thirty five completed both interviews. Subjects were asked about their medication, and about the advice sought from community pharmacists, on both drug and non-drug related health issues. Medication had been altered during the 6-month interval in 101 (23%) of people, but only 15 of these had discussed the change with a pharmacist. The majority of those who did discuss their medication, however, found the exchange helpful. Only 1% of the sample had discussed a health problem not related to drugs with a pharmacist in the previous month, although once again such discussions were felt to be useful. Of the total sample, 79% said they would never discuss medication-related issues with a community pharmacist, and 83% would not discuss other health matters. The majority of this sample - 96% - expressed a preference to discuss these issues with their general practitioner.