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Biomedical subjects

R Shaw

Publications and source records attributed to R Shaw.

At least 163 records · Page 9Linked to original sources
PubMed1978

Calcific constrictive pericarditis in Degos' disease.

A 31-year-old woman presented with symptoms and signs of constrictive pericarditis. She had a history of Degos' disease, a rare disorder characterized by skin and bowel lesions thought to be secondary to vasculitis. A chest roentgenogram showed extensive calcification of the pericardium. Although pleural and pericardial involvement has been reported in this disease, constrictive pericarditis is most unusual, and radiographically demonstrable calcification of the pericardium has not been reported previously.

Adult↗
PubMed1978

Effect of endotoxin on uterine cycle AMP in pregnant mice.

The effect of endotoxin (LPS) on uterine cAMP was determined by measuring the levels of cAMP and cAMP phosphodiesterase after challenge. Two LPS preparations, isolated from wild type (WT) and Re chemotype mutant cells of Salmonella typhimurium were used. The pattern of termination differed with WT LPS resulting in expulsion of the fetuses, and Re LPS primarily causing the resorption of the fetuses. The animals challenged with WT LPS showed a decrease in uterine cAMP when the mice were starting to expel the fetuses while the Re LPS treated group maintained control levels of cAMP. Cyclic AMP phosphodiesterase also decreased in WT LPS and not the Re LPS group. These results suggest the possibility that uterine cAMP is involved in the expulsion of the fetuses.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1977

Investigations of black bronchoalveolar human lavage fluid.

The removal by bronchoalveolar lavage (two occasions) of 10(11) black macrophages containing crystals of aluminum silicate, large amounts of amorphous carbon, and oxidized lipids was followed by considerable improvement in gas exchange in a patient. Sixty-eight percent of these pulmonary macrophages were viable and normal, as judged by chemotatctic and phagocytic activity. Except for cigarettes, no source for the previously mentioned ingested foreign substances was found. These observations suggest that removal by lavage of nonviable macrophages laden with foreign bodies from distal portions of the lungs of pulmonary patients may be therapeutically useful.

Carbon↗
PubMed1977

Postmyocardial infarction complications requiring surgery.

Papillary muscle rupture, ventricular septal defect, and ventricular aneurysm represent complications of myocardial infarction that require surgical intervention. Since operative mortality and morbidity are increased in proportion to the degree of myocardial and pulmonary disease, early diagnosis and surgical intervention is mandatory. Diagnostic procedures of choice include careful and serial ECG analysis and cardiac auscultation, especially in patients with postinfarction refractory angina or congestive heart failure; Swan-Ganz catheterization, echocardiography; and, in appropriate instances, ventricular and coronary angiography should also be performed preoperatively. With early identification of patients at risk of developing these complications, and careful preoperative hemodynamic studies, surgical repair should lead to improvement in myocardial function and more effective response to post-operative medications in patients previously resistant to such therapy.

Echocardiography↗
PubMed1976

Mutations masking the lambda cin-1 mutation.

A lambda cnc mutation masks the phenotype of the lambda cin-1 mutation. Eleven cnc mutations have been found. All appear to be identical and all map at a site just to the right of the cin-1 site. It is probable that cin-1 and cnc affect adjacent, or almost adjacent nucleotide pairs. Neither the cin-1 nor the cnc mutation involves large additions or deletions of genetic material.

Chromosome Mapping↗
PubMed1976

Potato tuber callus: validation as a biochemical tool.

Callus was initiated from explants of tubers of the Norchip cultivar of Solanum tuberosum L. and grown on medium with a single carbon source and without addition of coconut milk, protein hydrolysate, or amino acid. Callus samples were harvested at intervals and compared to mature tubers for which there was good biochemical knowledge.The amino acid spectrum, the glycoalkaloid content, and the properties of the isolated invertase and sucrose synthetase were similar in callus and in tuber. Significantly the level of sucrose synthetase varied with the age of the developing callus just as it did with the age of the developing tuber. Of greater significance, levels of reducing sugars and invertase varied with the age of developing callus and also with time and temperature of storage after the callus has ceased growth. Similar changes occur in intact tubers.Callus and tuber biochemistry differed in the amount of deposited starch and in the absence of potato invertase inhibitor.

Journal Article↗